The telomerase-associated protein p43 is involved in anchoring telomerase in the nucleus

Journal of Cell Science

Volumn 116, Issue 9, 2003, Pages 1757-1761

  Möllenbeck, Matthias ^a   Postberg, Jan ^a   Paeschke, Katrin ^a   Rossbach, Michael ^a   Jönsson, Franziska ^a   Lipps, Hans J ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Ciliates; La autoantigen; Nuclear matrix; Replication factory; RNAi; Telomerase

Indexed keywords

AUTOANTIGEN; PROTEIN P43; PROTEIN SUBUNIT; PROTOZOAL PROTEIN; RNA; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL DIVISION; CELL NUCLEUS MATRIX; CONTROLLED STUDY; EUKARYOTIC CELL; EUPLOTES; IN VITRO STUDY; IN VIVO STUDY; MACRONUCLEUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; TELOMERE;

ANIMALS; BASE SEQUENCE; CELL NUCLEUS; DNA, PROTOZOAN; EUPLOTES; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN SUBUNITS; PROTOZOAN PROTEINS; RNA INTERFERENCE; TELOMERASE;

CILIOPHORA; EUKARYOTA; EUPLOTES; MYXOZOA; PROTOZOA; SPIROTRICHEA;

EID: 0038664256     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00351     Document Type: Article

References (23)

1. Aigner, S., Lingner, J., Goodrich, K. J., Grosshans, C. A., Shevchenko, A., Mann, M. and Cech, T. R. (2000). Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 19, 6230-6239.
2. Ammermann, D., Steinbruck, G., Berger, L. V. and Hennig, W. (1974). The development of the macronucleus in the ciliated protozoan Stylonychia mytilus. Chromosoma 45, 401-429.
3. Bryan, T. M., Sperger, J. M., Chapman, K. B. and Cech, T. R. (1998). Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc. Natl. Acad. Sci. USA 95, 8479-8484.
4. Carlson, D. L., Skopp, R. and Price, C. M. (1997). DNA-binding properties of the replication telomere protein. Biochemistry 36, 15900-15908.
5. Chang, Y. N., Kenan, D. J., Keene, J. D., Gatignol, A. and Jeang, K. T. (1994). Direct interactions between autoantigen La and human immunodeficiency virus leader RNA. J. Virol. 68, 7008-7020.
6. Cong, Y. S., Wright, W. E. and Shay, J. W. (2002). Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 66, 407-425.
7. Cook, P. R. (1999). The organization of replication and transcription. Science 284, 1790-1795.
8. Dijkwel, P. A. and Hamlin, J. L. (1988). Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells. Mol. Cell. Biol. 8, 5398-5409.
9. Fang, G. and Cech, T. R. (1995). Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. J. Cell Biol. 130, 243-253.
10. Greider, C. W. and Blackburn, E. H. (1996). Telomeres, telomerase and cancer. Sci. Am. 274, 92-97.
11. Grimm, C., Lund, E. and Dahlberg, J. E. (1997). In vivo selection of RNAs that localize in the nucleus. EMBO J. 16, 793-806.
12. Jackson, D. A., Yuan, J. and Cook, P. R. (1988). A gentle method for preparing cyto- and nucleo-skeletons and associated chromatin. J. Cell. Sci. 90, 365-378.
13. Jonsson, F. and Lipps, H. J. (2002). The Biology of Telomeres in Hypotrichous Ciliates. In Telomerases, Telomeres and Cancer (ed. G. Krupp and R. Parwaresch), pp. 205-222. Landes Bioscience, Kluwer Academic/Plenum Publishers.
14. Jonsson, F., Postberg, J., Schaffitzel, C. and Lipps, H. J. (2002). Organization of the macronuclear gene sized pieces of stichotrichous ciliates into higher order structure via telomere-matrix interactions. Chromosome Res. 10, 445-453.
15. Lingner, J., Hendrick, L. L. and Cech, T. R. (1994). Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev. 8, 1984-1998.
16. Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V. and Cech, T. R. (1997). Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567.
17. Maraia, R. J. (2001). La protein and the trafficking of nascent RNA polymerase iii transcripts. J. Cell Biol. 153, F13-F18.
18. Postberg, J., Juranek, S. A., Feiler, S., Kortwig, H., Jönsson, F. and Lipps, H. J. (2001). Association of the telomere-telomere binding protein-complex of hypotrichous ciliates with the nuclear matrix and dissociation during replication. J. Cell Sci. 114, 1861-1866.
19. Prescott, D. M. (1994). The DNA of ciliated protozoa. Microbiol. Rev. 58, 233-267.
20. Schaffitzel, C., Berger, I., Postberg, J., Hanes, J., Lipps, H. J. and Pluckthun, A. (2001). In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. Proc. Natl. Acad. Sci. USA 98, 8572-8577.
21. Shay, J. W. and Wright, W. E. (2001). Telomeres and telomerase: implications for cancer and aging. Radiat. Res. 155, 188-193.
22. Timmons, L. and Fire, A. (1998). Specific interference by ingested dsRNA. Nature 395, 854.
23. Vaziri, H. and Benchimol, S. (1998). Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279-282.