Effect of tranexamic acid incorporated in fibrin sealant clots on the cell behavior of neuronal and nonneuronal cells

Journal of Neuroscience Research

Volumn 72, Issue 6, 2003, Pages 734-746

  Cox, S ^a   Cole, M ^a   Mankarious, S ^a   Tawil, Bill N ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

Adhesion; Fibrin sealant; Neurons; Proliferation

Indexed keywords

APROTININ; FIBRIN GLUE; TRANEXAMIC ACID;

ARTICLE; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EXTRACELLULAR MATRIX; FIBRIN CLOT; FIBROBLAST; GLIA CELL; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEACHING; NERVE CELL; NEUROSURGERY; PRIORITY JOURNAL;

CELL ADHESION; CELL DIVISION; CELL LINE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRIN TISSUE ADHESIVE; FIBROBLASTS; HUMANS; NEUROGLIA; NEURONS; TRANEXAMIC ACID; TUMOR CELLS, CULTURED;

EID: 0038658793     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10623     Document Type: Article

References (25)

1. Cole M, Cox S, Mogford J, Mana M, Ho W, Eggleston A, Mustoe T, Tawil N. 2001. Fibrin sealant Tissee1 is a biocombatible polymer for human-derived monocytes, fibroblasts and keratinocytes. Paper presented at The Wound Healing Society 11th Annual Conference, Albuquerque, NM.
2. Colman NW, Hirsh J, Marder VJ, Salzman EW, editors. 1987. Hemostasis and thrombosis: basic principles and clinical practice. Toronto: J.B. Lippincott.
3. Danen EH, Jansen KF, Klein CE, Smit NP, Ruiter DJ, van Muijen GN. 1996. Loss of adhesion to basement membrane components but not to keratinocytes in proliferating melanocytes. Eur J Cell Biol 70:69-75.
4. Dunn CJ, Goa KL. 1999. Tranexamic acid: a review of its use in surgery and other indications. Drugs 57:1005-1032.
5. Furtmuller R, Schlag MG, Berger M, Hopf R, Huck S, Sieghart W, Redl H. 2002. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a γ-aminobutyric acid a receptor antagonistic effect. J Pharmacol Exp Ther 301:168-173.
6. Gailit J, Clark C, Newman D, Tonnesen MG, Mosesson MW, Clark RA. 1997. Human fibroblasts bind directly to fibrinogen at rgd sites through integrin alpha(v) beta3. Exp Cell Res 232:118-126.
7. Giancotti FG, Ruoslahti E. 1999. Integrin signaling. Science 285:1028-1032.
8. Hoylaerts M, Lijnen HR, Collen D. 1981. Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta 673:75-85.
9. Hynes RO. 1987. Integrins: a family of cell surface receptors. Cell 48:549-554.
10. Ishimura M, Tamai S, Fujisaw Y. 1991. Arthroscopic meniscal repair with fibrin glue. Arthroscopy 7:177-181.
11. Juliano RL, Haskill S. 1993. Signal transduction from the extracellular matrix. J Cell Biol 120:577-585.
12. Longstaff C. 1994. Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents. Blood Coag Fibrinol 5:537-542.
13. Martinowitz U, Saltz R. 1996. Fibrin sealant. Curr Opin Hematol 3:395-402.
14. Meredith JE, Fazeli B, Schwartz MA. 1993. The extracellular matrix as a cell survival factor. Mol Biol Cell 9:953-961.
15. Mujtaba T, Mayer-Proschel M, Rao MS. 1998. A common neural progenitor for the CNS and PNS. Dev Biol 200:1-15.
16. Narakas A. 1988. The use of fibrin glue in repair of peripheral nerves. Orthop Clin North Am 19:187-199.
17. Pelligrini A, Giaretta D, Chemello R, Zanotto L, Testa G. 1982. Feline generalized epilepsy induced by tranexamic acid (AMCA). Epilepsia 23:35-45.
18. Ramstrom G, Blomback M. 1975. Tooth extractions in hemophiliacs. Int J Oral Surg 4:1-17.
19. Schlag G, Redl H, editors. 1986. Fibrin sealent in operative surgery opthalmology. In: Neurosurgery, vol 2. Berlin: Springer-Verlag.
20. Schlag MG, Hopf R, Redl H. 2000. Convulsive seizures following subdural application of fibrin sealant containing tranexamic acid in a rat model. Neurosurgery 47:1463-1467.
21. Schlag MG, Hopf R, Zifko U, Redl H. 2002. Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats. Acta Neurochir 144:63-69.
22. Sundstrom C, Nilsson K. 1976. Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17:565-577.
23. Tawil NJ, Grandori C, Hynes RO. 1995. Do integrins have an effect on cell cycle? Paper presented at the Gordon Conference, Fibronectin, Integrins and Related Molecules, Oxnard, CA.
24. Vermeulen M, Lindsay KW, Murret GD. 1984. Antifibrinolytic treatment in subarachnoid hemorrhage. N Engl J Med 311:432-437.
25. Wolner E. 1982. Fibrin gluing in cardiovascular surgery. Thorac Cardiovasc Surg 30:236-237.