Identification of an enhancer of the human activating protein-2α gene that contains a critical Ets1 binding site

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 7, 2003, Pages 3305-3311

  Cheng, You Hong ^a,b   Handwerger, Stuart ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DEOXYRIBONUCLEASE I; DNA; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR ETS 1;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; ENHANCER REGION; GENE DELETION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PLACENTA; PLASMID; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THIRD TRIMESTER PREGNANCY; WESTERN BLOTTING;

5' FLANKING REGION; BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; DEOXYRIBONUCLEASE I; DNA FOOTPRINTING; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE DELETION; HUMANS; MOLECULAR SEQUENCE DATA; PREGNANCY; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSFECTION; TROPHOBLASTS;

POLYOMAVIRUS; SIMIAE; SIMIAN VIRUS 40;

EID: 0038637214     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021831     Document Type: Article

References (25)

1. Williams T, Admon A, Luscher B, Tjian R 1988 Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev 2:1557-1569
2. Nottoli T, Hagopian-Donaldson S, Zhang J, Perkins A, Williams T 1998 AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proc Natl Acad Sci USA 95:13714-13719
3. Zhang J, Hagopian-Donaldson S, Serbedzija G, Elsemore J, Plehn-Dujowich D, McMahon AP, Flavell RA, Williams T 1996 Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 381:238-241
4. Philipp J, Mitchell PJ, Malipiero U, Fontana A 1994 Cell type-specific regulation of expression of transcription factor AP-2 in neuroectodermal cells. Dev Biol 165:602-614
5. Werling U, Schorle H 2002 Transcription factor gene AP-2γ essential for early murine development. Mol Cell Biol 22:3149-3156
6. Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T 2002 Transcription factor AP-2γ is essential in the extra-embryonic lineages for early postimplantation development. Development 129:2733-2747
7. Johnson W, Albanese C, Handwerger S, Williams T, Pestell RG, Jameson JL 1997 Regulation of the human chorionic gonadotropin α- and β-subunit promoters by AP-2. J Biol Chem 272:15405-15412
8. Richardson BD, Langland RA, Bachurski CJ, Richards RG, Kessler CA, Cheng YH, Handwerger S 2000 Activator protein-2 regulates human placental lactogen gene expression. Mol Cell Endocrinol 160:183-192
9. Cheng YH, Handwerger S 2002 AP-2α modulates human corticotropin-releasing hormone gene expression in the placenta by direct protein-protein interaction. Mol Cell Endocrinol 191:127-136
10. Pena P, Reutens AT, Albanese C, D'Amico M, Watanabe G, Donner A, Shu IW, Williams T, Pestell RG 1999 Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Mol Endocrinol 13:1402-1416
11. Shi D and Kellems RE 1998 Transcription factor AP-2γ regulates murine adenosine deaminase gene expression during placental development. J Biol Chem 273:27331-27338
12. Creaser PC, D'Argenio DA, Williams T 1996 Comparative and functional analysis of the AP2 promoter indicates that conserved octamer and initiator elements are critical for activity. Nucleic Acids Res 24:2597-2605
13. Bauer R, Imhof A, Pscherer A, Kopp H, Moser M, Seegers S, Kerscher M, Tainsky MA, Hofstaedter F, Buettner R 1994 The genomic structure of the human AP-2 transcription factor. Nucleic Acids Res 22:1413-1420
14. Imhof A, Schuierer M, Werner O, Moser M, Roth C, Bauer R, Buettner R 1999 Transcriptional regulation of the AP-2α promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Mol Cell Biol 19:194-204
15. Bachurski CJ, Kelly SE, Glasser SW, Currier TA 1997 Nuclear factor I family members regulate the transcription of surfactant protein-C. J Biol Chem 272:32759-32766
16. Luton D, Sibony O, Oury JF, Blot P, Dieterlen-Lievre F, Pardanaud L 1997 The c-ets1 protooncogene is expressed in human trophoblast during the first trimester of pregnancy. Early Hum Dev 47:147-156
17. Iljin K, Dube A, Kontusaari S, Korhonen J, Lahtinen I, Oettgen P, Alitalo K 1999 Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. FASEB J 13:377-386
18. Sementchenko VI, Watson DK 2000 Ets target genes: past, present and future. Oncogene 19:6533-6548
19. Fafeur V, Tulasne D, Queva C, Vercamer C, Dimster V, Mattot V, Stehelin D, Desbiens X, Vandenbunder B 1997 The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells. Cell Growth Differ 8:655-665
20. L expression correlates with primary macrophage differentiation, activation of functional competence, and survival and results from synergistic transcriptional activation by Ets2 and PU.1. J Biol Chem 276:17800-17807
21. Wasylyk B, Wasylyk C, Flores P, Begue A, Leprince D, Stehelin D 1990 The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature 346:191-193
22. Kim WY, Sieweke M, Ogawa E, et al. 1999 Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. EMBO J 18:1609-1620
23. Tian G, Erman B, Ishii H, Gangopadhyay SS, Sen R 1999 Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins. Mol Cell Biol 19:2946-2957
24. Lindemann RK, Ballschmieter P, Nordheim A, Dittmer J 2001 Transforming growth factor β regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism. J Biol Chem 276:46661-46670
25. Dittmer J, Gegonne A, Gitlin SD, Ghysdael J, Brady JN 1994 Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1. J Biol Chem 269:21428-21434