Paradoxical effects of pyruvate on cardiac contractile function under normal and high glucose in ventricular myocytes

Pharmacological Research

Volumn 48, Issue 1, 2003, Pages 25-29

  Ren, Jun ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Cell shortening; Pyruvate; Ventricular myocytes

Indexed keywords

PYRUVIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; MALE; MUSCLE CONTRACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SUPPLEMENTATION;

EID: 0038627838     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(03)00083-5     Document Type: Article

References (24)

1. Galderisi M., Anderson K.M., Wilson P.W.F., Levy D. Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am. J. Cardiol. 68:1991;85-89.
2. Ren J., Davidoff A.J. Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes. Am. J. Physiol. 272:1997;H148-H158.
3. Dutta K., Podolin D.A., Davidson M.B., Davidoff A.J. Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance. Diabetes. 50:2001;1186-1192.
4. 2+] and pH in rat skinned cardiac myocytes. Am. J. Physiol. 269:1995;H1656-H1663.
5. 2+ handling in ventricular myocytes isolated from diabetic rats. Am. J. Physiol. 270:1996;H1529-H1537.
6. Ren J., Gintant G.A., Miller R.E., Davidoff A.J. High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner. Am. J. Physiol. 273:1997;H2876-H2883.
7. 2+ exchanger activity in the diabetic heart. Cardiovasc. Res. 34:1997;129-136.
8. Cai L., Kang Y.J. Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovasc. Toxicol. 1:2001;181-193.
9. Pogatsa G. New concepts in the therapy of diabetic cardiopathies. Orv. Hetil. 138:1997;1491-1494.
10. Mallet R.T., Sun J. Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics. Cardiovasc. Res. 42:1999;149-161.
11. Mallet R.T. Pyruvate: metabolic protector of cardiac performance. Proc. Soc. Exp. Biol. Med. 223:2000;136-148.
12. Strodter D., Overbeck A., Syed Ali S., Seitz S., Bretzel R.G., Federlin K. Improvement of cardiac performance and metabolism in long-term diabetes mellitus after treatment with insulin. Exp. Clin. Endocrinol. Diabetes. 103:1995;354-360.
13. 2+ cycling in isolated failing human myocardium. Circulation. 105:2002;194-199.
14. Hall J.L., Stanley W.C., Lopaschuk G.D., Wisneski J.A., Pizzurro R.D., Hamilton C.D.et al. Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work. Am. J. Physiol. 271:1996;H2320-H2329.
15. Sugden M.C., Holness M.J. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr. Drug Targets Immune Endocrinol. Metabol. Disord. 2:2002;151-165.
16. Davidoff A.J., Ren J. Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes. Am. J. Physiol. 272:1997;H159-H167.
17. 2+ transients in adult rat ventricular myocytes. Diabetes. 48:1999;2059-2065.
18. Martin B.J., Valdivia H.H., Bunger R., Lasley R.D., Mentzer R.M. Jr. Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes. Am. J. Physiol. 274:1998;H8-H17.
19. 2+ regulation in cardiac myocytes from normal and diabetic rats. Clin Exp. Pharmacol. Physiol. 26:1999;889-897.
20. Sowers J.R., Epstein M. Diabetes mellitus and associated hypertension, vascular disease and nephropathy: an update. Hypertension. 26:1995;869-879.
21. 2+ exchanger expression in cardiac myocytes (abstract). Circulation. 104:2001;247.
22. Privratsky J.R., Carlson E.C., Ren J. Cardiac-specific overexpression of metallothionein prevents glutathione depletion-induced oxidative cardiomyopathy in isolated ventricular myocytes (abstract). Circulation. 106:2002;II201-II202.
23. Mallet R.T., Squires J.E., Bhatia S., Sun J. Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium. J. Mol. Cell. Cardiol. 34:2002;1173-1184.
24. Chatham J.C., Seymour A.M. Cardiac carbohydrate metabolism in Zucker diabetic fatty rats. Cardiovasc. Res. 55:2002;104-112.