Structure-activity relationship for chemical skin permeation enhancers: Probing the chemical microenvironment of the site of action

Journal of Pharmaceutical Sciences

Volumn 92, Issue 6, 2003, Pages 1305-1322

  Warner, Kevin S ^a   Li, S Kevin ^a   He, Ning ^a   Suhonen, T Marjukka ^a,b   Chantasart, Doungdaw ^a,c   Bolikal, Durgadas ^d   Higuchi, William I ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c MAHIDOL UNIVERSITY   (Thailand)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

Chemical permeation enhancers; Enhancer mechanism; Octanol water partition coefficient; Structure activity relationship

Indexed keywords

1,2 DIHYDROXYPROPYL DECANOATE; 1,2 DIHYDROXYPROPYL OCTANOATE; 1,2,3 NONANETRIOL; 1,3 DIOXOLANE DERIVATIVE; 2 AZACYCLOHEPTANONE DERIVATIVE; 2 PIPERIDONE DERIVATIVE; 2 PYRROLIDINONE; ALKANE DERIVATIVE; ALKANEDIOL DERIVATIVE; ALKANOL; AMIDE; BUFFER; CORTICOSTERONE; CYCLOHEPTANE DERIVATIVE; DECANOIC ACID DERIVATIVE; DECANOL; GLUCOPYRANOSIDE; HEXANE; HEXANOL; HYDROXYPROLINE N DECANAMIDE C ETHYLAMIDE; NONANOIC ACID; OCTANOIC ACID DERIVATIVE; OCTANOL; PHOSPHATE; PIPERIDONE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG STRUCTURE; DRUG TRANSPORT; ENERGY TRANSFER; ENHANCER REGION; HYDROPHOBICITY; MOUSE; NONHUMAN; NUDE MOUSE; PARTITION COEFFICIENT; SKIN PERMEABILITY; STRATUM CORNEUM; STRUCTURE ACTIVITY RELATION;

EID: 0038621839     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10367     Document Type: Article

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