Effect of bilayer disruption on transdermal transport of low-molecular weight hydrophobic solutes

Pharmaceutical Research

Volumn 18, Issue 7, 2001, Pages 1018-1023

  Mitragotri, S ^a  

^a University of California at Santa Barbara   (United States)

Author keywords

Chemical enhancer; Diffusion; Enhancers; Modeling; Scaled particle theory; Transdermal

Indexed keywords

DRUG CARRIER; UNCLASSIFIED DRUG; ALDOSTERONE; CORTICOSTERONE; LIDOCAINE; NAPHTHOL DERIVATIVE; TESTOSTERONE;

ARTICLE; BILAYER MEMBRANE; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG UPTAKE; HYDROPHOBIC DRUG; HYDROPHOBICITY; LIPID BILAYER; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEMBRANE DAMAGE; MOLECULAR WEIGHT; NONHUMAN; PARTICLE RADIATION; PARTITION COEFFICIENT; PREDICTION; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN PERMEABILITY; STRATUM CORNEUM; THEORY; BIOLOGICAL MODEL; CHEMISTRY; DIFFUSION; DRUG EFFECT; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; PARTICLE SIZE; PERMEABILITY; SKIN; SOLUTION AND SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, CUTANEOUS; ALDOSTERONE; BIOLOGICAL TRANSPORT; CORTICOSTERONE; DIFFUSION; HYDROPHOBICITY; LIDOCAINE; LIPID BILAYERS; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; NAPHTHOLS; PARTICLE SIZE; PERMEABILITY; SKIN; SOLUTIONS; TESTOSTERONE;

EID: 0034741916     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010952731205     Document Type: Article

References (25)

1. Sonophoresis I. The use of high-frequency ultrasound to enhance transdermal drug delivery
2. Effect of ultrasound on transdermal drug delivery to rats and guinea pigs
3. A mechanistic study of ultrasonically enhanced transdermal drug delivery
4. Ultrasound-mediated transdermal protein delivery
5. Iontophoretic drug delivery
6. Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery
7. A Computer simulation of free-volume distributions and related structural properties in a model bilayer
8. Permeation process of small molecules across lipid membranes studies by molecular dynamics simulations
9. Solute partitioning into chain molecule interphases: Monolayers, bilayer membranes, and micelles
10. Molecular distribution in interphases: Statistical mechanical theory combined with molecular dynamics simulation of a model bilayer
11. Simulation of water transport through a lipid membrane
12. A theoretical analysis of partitioning, diffusion, and permeation across lipid bilayers
13. Phospholipid affect stratum corneum lipid bilayers fluidity and drug partitioning into the bilayers
14. Heterogenity effects of permeability-partition coefficient relationship in human stratum corneum
15. In situ determination of partition and diffusion coefficients in the lipid bilayers of the stratum corneum
16. Effect of ultrasound on solute partition and diffusion coefficients in the stratum corneum
17. Solute partitioning into lipid bilayer systems
18. Synergistic effect of ultrasound and chemical enhancers on transdermal drug delivery
19. Contribution of drug solubilization, partitioning, barrier disruption, and solvent permeation to the enhancement of skin permeation of various compounds with fatty acids and amines
20. Effects of transdermal penetration enhancers on the permeability of shed snakeskin
21. Synthesis and enhancing effect of dodecyl 2-(n,n-dimethylamino)proprionate on the transepidermal delivery of indomethacin, clonidine, and hydrocortisone
22. Transdermal delivery of drugs with differing lipophilicities using azone analogs as dermal penetration enhancers
23. Evidence that oleic acid exists in a separate phase within stratum corneum lipids
24. An explanation for the variation of the sonophoretic transdermal transport enhancement from drug to drug