High-dose interferon results in high HBsAg seroclearance in children with chronic hepatitis B infection

Turkish Journal of Pediatrics

Volumn 45, Issue 2, 2003, Pages 123-128

  Ertem, Deniz ^a   Acar, Yeşim ^a   Karaa, Esin Kotiloǧlu ^a   Pehlivanoǧlu, Ender ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Children; Hepatitis B virus; High dose interferon

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIVIRUS AGENT; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; IMMUNOSUPPRESSIVE AGENT; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; VIRUS DNA;

ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG TOLERABILITY; FEBRILE CONVULSION; FEMALE; FEVER; FLU LIKE SYNDROME; HEPATITIS B; HEPATITIS B VIRUS; HISTOPATHOLOGY; HUMAN; LIVER BIOPSY; MALE; MYALGIA; NEUTROPENIA; SEROCONVERSION; WEIGHT REDUCTION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; TREATMENT OUTCOME;

EID: 0038601666     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Bortolotti F, Calzia R, Cadrobbi P, et al. Liver cirrhosis associated with hepatitis B virus infection in childhood. J Pediatr 1986; 108: 224-227.
2. Wu TC, Tong MJ, Heang B, Lee SD, Hu MM. Primary hepatocellular carcinoma and hepatitis B infection during childhood. Hepatology 1987; 7: 46-48.
3. Committee on Infectious Disease. Universal hepatitis B immunisation. Pediatrics 1992; 89: 795-799.
4. Suk-Fong Lok A. Hepatitis B infection: pathogenesis and management. J Hepatol 2000; 32 (Suppl) 89: 97.
5. Alexander GJ, Brahm J, Fagan EA, et al. Loss of HBsAg with interferon therapy in chronic hepatitis B virus infection. Lancet 1987; 1: 66-68.
6. Hoofnagle JH, Peters MG, Mullen KD, et al. Randomised controlled trial of recombinant human α-interferon in patients with chronic hepatitis B. Gastroenterology 1988; 95: 1318-1325.
7. Perillo RP, Schiff E, Davis GL, et al. The Hepatitis Interventional Therapy Group. A randomised controlled trial of interferon α-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 313: 295-301.
8. Wong DK, Cheung AM, O'Rourke K, et al. Effect of α-interferon treatment in patients with hepatitis B e antigen positive chronic hepatitis B: a meta-analysis. Ann Int Med 1993; 119: 312-323.
9. Sokal EM, Conjeevaram HS, Roberts EA, et al. Interferon alpha therapy for chronic hepatitis B in children. A multinational randomised controlled trial. Gastroenterology 1998; 114: 988-995.
10. Louis-Jacques O, Olson AD. Cost-benefit analysis of interferon therapy in children with chronic active hepatitis B. J Pediatr Gastroenterol Nutr 1997; 24: 25-32.
11. Ruiz-Moreno M. Interferon treatment in children with chronic hepatitis B. J Hepatol 1995; 22 (Suppl): 49-51.
12. Ruiz-Moreno M, Rua MJ, Molina J, et al. Prospective, randomised controlled trial of interferon-α in children with chronic hepatitis B. Hepatology 1991; 13: 1035-1039.
13. La Bonda F, Ruiz-Moreno M, Carrero V, et al. Recombinant α-2 interferon treatment in children with chronic hepatitis B. Lancet 1988; 1: 250.
14. Ruiz-Moreno M, Jimenez J, Porres JC, Bartolome J, Moreno A, Carrero V. A controlled trial of recombinant interferon-α in Caucasian children with chronic hepatitis B. Digestion 1990; 45: 26-33.
15. Utilli R, Sagnelli E, Galanti B, et al. Prolonged treatment of children with chronic hepatitis B with recombinant α-2A interferon: a controlled randomised study. Am J Gastroenterol 1991; 86: 327-330.
16. Jara P, Bortolotti F. Interferon alpha treatment of chronic hepatitis B in childhood: a consensus advice based on experience in European children. J Pediatr Gastroenterol Nutr 1999; 29: 163-170.
17. Bruguera M, Amat L, Garcia O, et al. Treatment of chronic hepatitis B in children with recombinant alfa interferon. Different response according to age at infection. J Clin Gastroenterol 1993; 17: 296-299.
18. Sokal E, Wirth S, Goyens P, Depreterre A, Cornu C. Interferon alfa 2b therapy in children with chronic hepatitis B. Gut 1993; 34 (Suppl): 87-90.
19. Vajro P, Tedesco M, Fontanella A, et al. Prolonged and high dose recombinant interferon alpha-2b alone or after prednisone priming accelerates termination of active viral replication in children with chronic hepatitis B. Pediatr Infect Dis J 1996; 15: 223-231.
20. Vajro P, Migliaro F, Fontanella A, Orso G. Interferon: a meta-analysis of published studies in pediatric chronic hepatitis B. Acta Gastroenterol Belg 1998; 61: 219-223.
21. Fattovich G, Guistina G, Sanchez-Tapiaz J, et al. Delayed clearence of serum HBsAg in compensated cirrhosis B: relation to interferon alpha therapy and disease prognosis. European Concerted Action on Viral Hepatitis (EUROHEP). Am J Gastroenterol 1998; 93: 896-900.
22. Knodell RG, Ishak KG, Black WG, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-435.
23. Chean PL, Looi LM, Lin HP, Yap SF. Childhood primary hepatocellular carcinoma and hepatitis B virus infection. Cancer 1990; 60: 174-176.
24. Fujisawa T, Komatsu H, Inui A, et al. Long-term outcome of chronic hepatitis B in adolescents or young adults in follow-up from childhood. J Pediatr Gastroenterol Nutr 2000; 30: 201-206.
25. Krogsgaard K. The long-term effect of treatment with interferon-alpha 2a in chronic hepatitis B.The Long-Term Follow-up Investigator Group. The European Study Group on Viral Hepatitis (EUROHEP). Executive Team on Anti-Viral Treatment. J Viral Hepatol 1998; 5: 389-397.
26. Torre D, Tambini R. Interferon-alpha therapy for chronic hepatitis B in children: a meta-analysis. Clin Infect Dis 1996; 23: 131-137.
27. Da Silva LC, Madruga CL, Carrilho FJ, et al. Spontaneous hepatitis B surface antigen clearance in long-term follow-up study of patients with chronic type B hepatitis. Lack of correlation with hepatitis C and D virus superinfection. J Gastroenterol 1996; 31: 696-701.
28. Ozen H, Kocak N, Yuce A, Gurakan F. Retreatment with higher dose interferon alpha in children with chronic hepatitis B infection. Pediatr Infect Dis 1999; 18: 694-697.
29. Bartoletti F, Jara P, Barnera C, et al. Long-term effect of alpha interferon in children with chronic hepatitis B. Gut 2000; 46: 715-718.
30. Bartoletti F, Paloma J, Crivellaro C, et al. Outcome of chronic hepatitis B in Caucasian children during a 20-year observation period. J Hepatol 1998; 29: 184-190.
31. Jonas MM. Interferon alpha for viral hepatitis. J Pediatr Gastroenterol Nutr 1996; 23: 93-106.