Effect of PKC412, an inhibitor of protein kinase C, on spontaneous metastatic model mice

Anticancer Research

Volumn 23, Issue 2 B, 2003, Pages 1395-1399

  Nakamura, Kazuki ^a   Yoshikawa, Noriko ^a   Yamaguchi, Yu ^a   Kagota, Satomi ^a   Shinozuka, Kazumasa ^a   Kunitomo, Masaru ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Anti metastasis; B16 BL6 mouse melanoma cells; Chemo invasion; PKC inhibitor; Spontaneous metastatic mouse model

Indexed keywords

MATRIGEL; MIDOSTAURIN; PROTEIN KINASE C INHIBITOR;

AMPUTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; EXTRACELLULAR SPACE; FEMALE; FOOT PAD; GROWTH RATE; HINDLIMB; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; MELANOMA B16; METASTASIS; METASTASIS INHIBITION; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; COLLAGEN; DRUG COMBINATIONS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FEMALE; LAMININ; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PROTEIN KINASE C; PROTEOGLYCANS; SPECIFIC PATHOGEN-FREE ORGANISMS; STAUROSPORINE; TUMOR CELLS, CULTURED;

EID: 0038577028     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Omura S, Iwai Y, Hirano A, Nakagawa A, Awaya J, Tsuchiya H, Takahashi Y and Masuma R: A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J Antibiot 30: 275-282, 1977.
2. ++ dependent protein kinase. Biochem Biophys Res Commun 135: 397-402, 1986.
3. Gescher A: Analog of staurosporine: potential anticancer drugs? Gen Pharmac 31: 721-728, 1998.
4. Meyer T, Regenass U, Fabbro D, Alteri E, Rösel J, Müller M, Caravatti G and Matter A: A derivative of staurosporine (CGP41251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer 43: 851-856, 1989.
5. Fabbro D, Buchdunger E, Wood J, Mestan J, Hofmann F, Ferrari S, Mett H, O'Reilly T and Meyer T: Inhibitors of protein kinases: CGP41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther 82: 293-301, 1999.
6. Propper DJ, McDonald AC, Man A, Thavasu P, Balkwill F, Braybrooke JP, Caponigro F, Graf P, Dutreix C, Blackie R, Kaye SB, Ganesan TS, Talbot DC, HarrisAL and Twelves C: Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol 19: 1485-1492, 2001.
7. Valente P, Fassina G, Melchiori A, Masiello L, Cilli M, Vacca A, Onsto M, Santi L, Stetler-Stevenson WG and Albini A: TIMP-2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis. Int J Cancer 75: 246-253, 1998.
8. Ikegami Y, Yano S and Nakao K: Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. Jpn J Pharmacol 70: 65-72, 1996.
9. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SS, Kozlowski JM and McEwan RN: A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239-3245, 1987.
10. Ikegami Y, Yano S, Fujita F, Fujita M, Sakamoto Y, Murata N and Isowa K: Antitumor activity of the new selective protein kinase C inhibitor 4′-N-benzoyl staurosporine on murine and human tumor models. Arzneimittelforschung 45: 1225-1230, 1995.
11. O'Brian C, Vogel VG, Singletary SE and Ward NE: Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 49: 3215-3217, 1989.
12. Benzil DL, Finkelstein SD, Epstein MH and Finch PW: Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res 52: 2951-2956, 1992.
13. Fidler IJ: Selection of successive tumour lines for metastasis. Nat New Biol 242: 148-149, 1973.
14. Desaive C, Zietz S and Nicolini C: Size dependence of cell cycle parameters for lung metastases from B16 melanoma. Cancer Lett 4: 285-292, 1978.
15. Fridman R, Sweeney TM, Zain M, Martin GR and Kleinman HK: Malignant transformation of NIH-3T3 cells after subcutaneous coinjection with a reconstituted basement membrane (matrigel). Int J Cancer 51: 740-744, 1992.