The emergence of anti-dsDNA antibodies precedes nucleosome-specific antibodies in MRL/lpr and MRL/+ mice

Journal of Medical and Dental Sciences

Volumn 50, Issue 1, 2003, Pages 9-15

  Lu, Qing ^a   Kanai, Yoshiyuki ^b   Kubota, Tetsuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Anti DNA antibodies; MRL lpr mice; Nucleosome; Systemic lupus erythematosus

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; CELL NUCLEUS ANTIGEN; DNA; IMMUNOGLOBULIN G;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOLOGY; METABOLISM; MOUSE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NUCLEOSOME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODY SPECIFICITY; ANTIGENS, NUCLEAR; AUTOANTIBODIES; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; MICE, INBRED MRL LPR; NUCLEOSOMES;

EID: 0038548576     PISSN: 13428810     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Mohan C, Adams S, Stanik V, et al. Nucleosome: a major immunogen for pathogenic autoantidody-inducing T cells of lupus. J Exp Med 1993;177:1367-81.
2. Kaliyaperumal A, Mohan C, Wu W, et al. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J Exp Med 1996;183:2459-69.
3. Rumore P M, Steinman C R. Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone. J Clin Invest 1990;86:69-74.
4. Amoura Z, Piette J-C, Chabre H, et al. Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus. Correlation with serum antinucleosome antibody titers and absence of clear association with disease activity. Arthritis Rheum 1997;40:2217-25.
5. Burlingame R W, Rubin R L, Balderas R S, et al. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J Clin Invest 1993;91:1687-96.
6. Amoura Z, Chabre H, Koutouzov S, et al. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum 1994;37:1684-8.
7. Satake F, Watanabe N, Miyasaka N, et al. Induction of anti-DNA antibodies by immunization with anti-DNA antibodies: mechanism and characterization. Lupus 2000;9:489-97.
8. Mendlovic S, Brocke S, Shoenfeld Y, et al. Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci USA 1988;85:2260-4.
9. Desai D D, Krishnan M R, Swindle J T, et al. Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice. J Immunol 1993;151:1614-26.
10. Tincani A, Balestrieri G, Allegri F, et al. Induction of experimental SLE in naïve mice by immunization with human polyclonal anti-DNA antibody carrying the 16/6 idiotype. Clin Exp Rheumatol 1993;11:129-34.
11. Kanai Y, Takeda O, Miura K, et al. Induction of autoantibodies in normal mice by injection of nucleobindin and natural occurrence of antibodies against nucleobindin in autoimmune MRL/lpr/lpr mice. Immunol Lett 1995;45:35-42.
12. Moens U, Seternes O-M, Hey A W, et al. In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones. Proc Natl Acad Sci USA 1995;92:12393-7.
13. James J A, Harley J B. A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice. J Immunol 1998;160:502-8.
14. Arbuckle M R, Gross T, Scofield R H, et al. Lupus humoral autoimmunity induced in a primate model by short peptide immunization. J Invest Med 1998;46:58-65.
15. Kubota T, Watanabe N, Kanai Y, et al. Enhancement of oxidative cleavage of DNA by the binding sites of two anti-double-stranded DNA antibodies. J Biol Chem 1996;271:6555-61.
16. Tatchell K, van Holde K E. Reconstitution of chromatin core particles. Biochemistry 1997;16:5295-303.
17. Rhodes D, Laskey R A. Assembly of nucleosomes and chromatin in vitro. Methods Enzymol 1989;170:575-85.
18. Yager T D, McMurray C T, van Holde K E. Salt-induced release of DNA from nucleosome core particles. Biochemistry 1989;28:2271-81.
19. Kanai Y, Miwa M, Matsushima T, et al. Studies on anti-poly(adenosine diphosphate ribose) antibody. Biochem Biophys Res Comm 1974;59:300-6.
20. Kubota T, Kanai Y, Miyasaka N. Interpretation of the cross-reactivity of anti-DNA antibodies with cell surface proteins: the role of cell surface histones. Immunol Lett 1990;23:187-94.
21. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immuol 1985;37:269-390.
22. Watanabe-Fukunaga R, Brannan CI, Copeland NG, et al. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992;356:314-7.
23. Yoon Y S, Kim J W, Kang K W, et al. Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis. J Biol Chem 1996;271:9129-34.
24. Gilkeson G S, Pippen A M M, Pisetsky D S. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest 1995;95:1398-402.
25. Lu L, Kaliyaperumal A, Boumpas D T, et al. Major peptide autoepitopes for nucleosome-specific T cells of human lupus. J Clin Invest 1999;104:345-55.
26. Andreassen K, Moens U, Nossent H, et al. Termination of human T cell tolerance to histones by presentation of histones and polyomavirus T antigen provided that T antigen is complexed with nucleosomes. Arthritis Rheum 1999;42:2449-60.
27. Stemmer C, Richalet-Sécordel P, van Bruggen M, et al. Dual reactivity of several monoclonal anti-nucleosome autoantibodies for double-stranded DNA and a short segment of histone H3. J Biol Chem 1996;271:21257-61.
28. van Houten N, Budd R C. Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes. J Immunol 1992;149:2513-7.
29. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994;152:3685-92.