Aloe-emodin inhibited N-acetylation and DNA adduct of 2-aminofluorene and arylamine N-acetyltransferase gene expression in mouse leukemia L 1210 cells

Leukemia Research

Volumn 27, Issue 9, 2003, Pages 831-840

  Chung, Jing Gung ^a   Li, Yu Ching ^b   Lee, Yi Min ^b   Lin, Jing Pin ^a   Cheng, Kwork Chui ^c   Chang, Weng Cheng ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHUNGTAI INST HLTH SCI TECHNOL   (Taiwan)

^c JEN AI HOSPITAL   (Taiwan)

Author keywords

Aloe emodin; Arylamines (N acetyl 2 aminofluorene and 2 aminofluorene); Mouse leukemia cells; N Acetyltransferase

Indexed keywords

2 FLUORENYLAMINE; ALOE EMODIN; ARYLAMINE ACETYLTRANSFERASE; MESSENGER RNA;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; KINETICS; LEUKEMIA CELL; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0038541812     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(03)00017-1     Document Type: Article

References (37)

1. Hein D.W. Acetylator genotype and arylamine-induced carcinogenesis. Biochim. Biophys. Acta. 948:1988;37-66.
2. Fretland A.J.et al. Effect of nucleotide substutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition. Cancer Detect Prev. 26:2002;10-14.
3. Weber W.W., Hein D.W. N-Acetylation pharmacogenetics. Pharmacol. Rev. 37:1985;25-99.
4. Evans D.A.P. N-Acetyltransferase. Pharmacol. Ther. 42:1989;157-234.
5. Weber WW. The acetylator genes and drug response. New York: Oxford University Press; 1987. p. 21-55.
6. Lang N.P. Role of aromatic amine acetyltransferase in human colorectal cancer. Arch. Surg. 121:1986;1259-1261.
7. Roberts-Thomson I.C.et al. Diet, acetylator phenotype, and risk of colorectal neoplasia. Lancet. 347:1996;1373-1374.
8. Chen J.et al. A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Res. 58:1998;3307-3311.
9. Risch A.et al. Slow N-acetyltransferase genotype is a susceptibility factor in occupational and smoking related bladder cancer. Hum. Mol. Genet. 4:1995;231-236.
10. Brockmoller J.et al. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathine-S-transferase M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res. 56:1996;3915-3925.
11. Cartwright R.A. Role of N-acetyltransferase phenotype in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer. Lancet. 2:1982;842-846.
12. Einisto P.et al. Mutagenicity of 30 chemicals in S. typhimurium possessing different nitroreductase or O-acetyltransferase activities. Mutat. Res. 259:1991;95-102.
13. Kobashi K.et al. Metabolism of sennosides by human intestinal bacteria. Planta Med. 40:1980;225-236.
14. Westendorf J. Genotoxicity of naturally occurring hydroxyanthraquinone. Mutat. Res. 240:1990;1-12.
15. Driscoll J.S.et al. Structure-antitumor activity relationships among quinone derivatives. Cancer Chemother. Rep. 2(4):1974;1-362.
16. Grimaudo S.et al. Effects of highly purified anthraquinoid compounds from Aloe vera on sensitive and multidrug resistant leukemia cells. Oncol. Rep. 4:1997;341-343.
17. Pecere T.et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 60:2000;2800-2804.
18. Wang H.H.et al. Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori. Planta Med. 64:1998;176-178.
19. Chung J.G.et al. Distribution of 2-aminofluorene and p-aminobenzoic acid N-acetyltransferase activity in tissues of C57BL/6J rapid and B6.A-Nats slow acetylator congenic mice. Drug Metab. Dispos. 21:1993;1057-1063.
20. Chung J.G.et al. Inhibitory of N-acetyltransferase activity and DNA-2-aminofluorene adducts by glycyrrhizic acid in human colon tumour cells. Food Chem. Toxicol. 38:2000;163-172.
21. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
22. Levy G.A., Weber W.W. 2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines. Carcinogenesis. 10:1989;705-709.
23. Levy G.N.et al. 2-Aminofluorene metabolism and DNA adduct formation by mononuclear leukocytes from rapid and slow acetylator mouse strains. Carcinogenesis. 15:1994;353-357.
24. Blum M.et al. Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA Cell. Biol. 9:1990;193-203.
25. Ebisawa T., Deguchi T. Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferase. Biochem. Biophys. Res. Commun. 177:1991;1252-1257.
26. Ponte P.et al. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucl. Acids Res. 12:1984;1687-1696.
27. Cleland W.W. The statistical analysis of enzyme kinetics data. Adv. Enzymol. 29:1967;1-32.
28. Einisto P.et al. Mutagenicity of 30 chemicals in S. typhimurium possessing different nitroreductase or O-acetyltransferase activities. Mutat. Res. 259:1991;95-102.
29. Grant D.M.et al. Monomorphic and polymorphic human arylamine N-acetyltransferase: a comparison of liver isoenzymes and expressed products of two cloned genes. Mol. Pharmacol. 39:1991;184-191.
30. Minchin R.F.et al. N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferase expressed in COS-1 cells. Biochem. Biophys. Res. Commun. 185:1992;839-844.
31. Lu K.H.et al. The effect of paclitaxel on gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells. Food Chem. Toxicol. 40:2002;705-713.
32. Li Y.C.et al. Luteolin-inhibited arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human and mouse leukemia cells. Food Chem. Toxicol. 39:2001;641-647.
33. Zubay GL, et al. Principles of biochemistry. Wm. C. Brown Publishers; 1995. p. 135-53.
34. Thorgeirsson SS, et al. Metabolism, mutagenicity, carcinogenicity of aromatic amines. In: Hodgson J, Bend J, Philpot RM, editors. Reviews in biochemical toxicity, vol. 6. New York: Elsevier/North-Holland Biomedical Press; 1983. p. 349-86.
35. Hayes M.A.et al. Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver. JNCI. 76:1986;683-690.
36. Smith G.et al. Metabolic polymorphisms and cancer susceptibility. Cancer Surv. 25:1995;27-65.
37. Campbell D.A.et al. Characterization of arylamine acetyltransferase in the rabbit eye. Invest. Opththamol. Vis. Sci. 32:1991;2190-2200.