Attenuated metabolic response to surgery in tumor-bearing rats

Journal of Surgical Research

Volumn 110, Issue 2, 2003, Pages 371-377

  De Blaauw, Ivo ^a,b   Deutz, Nicolaas E P ^a   Hulsewe, Karel W ^a   Von Meyenfeldt, Maarten F ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Maasziekenhuis ^*  (Netherlands)

Author keywords

Cancer; Glutamine; Intestine; Protein turnover; Surgical stress; Trauma metabolism

Indexed keywords

LACTOSE; PHENYLALANINE DERIVATIVE; POLYAMINE; PROTEIN; RHAMNOSE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CANCER SURGERY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EXPERIMENTAL RAT; FEMALE; HYSTERECTOMY; INTESTINE; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; KINETICS; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; RAT; SURGICAL STRESS; TUMOR;

EID: 0038517914     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-4804(03)00041-6     Document Type: Article

References (38)

1. Gleeson M.H., Dowling R.H., Peters T.J. Intestinal structure and function after small bowel by-pass in the rat. Clin. Sci. 43:1972;731.
2. McNulan M.A., Tomkins A.M., Garlick P.J. The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem. J. 178:1979;373.
3. de Blaauw I., Deutz N.E.P., von Meyenfeldt M.F. In vivo amino acid metabolism of gut and liver during short and prolonged starvation. Am. J. Physiol. 270:1996;G298.
4. Preedy V.R., Paska L., Sudgen P.H., Schofiled P.S., Sugden M.C. The effects of surgical stress and short-term fasting on protein synthesis in vivo in diverse tissues of the mature rat. Biochem. J. 250:1988;179.
5. Carter E.A., Hatz R.A., Yarmush M.L., Tompkins R.G. Injury-induced inhibition of small intestinal protein and nucleic acid synthesis. Gastroenterology. 98:1990;1445.
6. Molina P.E., Abumrad N.N. Gut-derived proteolysis during insulin-induced hypoglycemia The pain that breaks down the gut . J. Parenter. Enter. Nutr. 18:1994;549.
7. Williams B.D., Wolfe R.R., Bracy D.P., Wasserman D.H. Gut proteolysis contributes essential amino acids during exercise. Am. J. Physiol. 270:1996;E85.
8. Waldegrave W.C.C.O.E.C. Guide for the Care and Use of Laboratory Animals. 1986;European Community Publication, Brussels.
9. Boyland E., Warren F.L. The induction of tumours by methylcholanthrene in two strains of mice. J. Pathol. Bact. 45:1937;171.
10. Popp M.B., Morrison S.D., Brennan M.F. Total parenteral nutrition in a methylcholanthrene-induced rat sarcoma model. Cancer Treat. Rep. 65:1981;137.
11. Burt M.E., Lowry S.F., Gorschboth C., Brennan M.F. Metabolic alterations in a noncachectic animal tumor system. Cancer. 47:1981;2138.
12. Chen M.K., Espat N.J., Bland K.I., Copeland E.M., Souba W.W. Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney. Ann. Surg. 217:1993;655.
13. Morrison S.D. In vivo estimation of size of experimental tumors. J. Natl. Cancer. Inst. 71:1983;407.
14. Heindorff H., Almdal T., Vilstrup H. Contradictory effects of uncomplicated versus complicated abdominal surgery on the hepatic capacity for urea synthesis in rats. J. Surg. Res. 49:1990;239.
15. Lee V.M., Wolfe B.M., Hansen R.J., Clifford A.J. Postsurgical muscle protein turnover in perfused hindquarters of the rat. J. Parenter. Enter. Nutr. 12:1988;452.
16. Heindorff H., Almdal T., Vilstrup H. Effects of hysterectomy and semi-starvation on amino acid gradients across liver, muscle and gut in rats. Clin. Nutr. 9:1990;253.
17. Dejong C.H.C., Kampman M.T., Deutz N.E.P., Soeters P.B. Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemia. Gastroenterology. 102:1992;936.
18. de Blaauw I., Deutz N.E.P., von Meyenfeldt M.F. In vivo protein and amino acid turnover in rats Effects of short-term and prolonged starvation . Clin. Sci. 90:1996;457.
19. van Eijk H.M.H., Rooyakkers D.R., Deutz N.E.P. Automated determination of polyamines by high performance liquid chromatography with simple sample preparation. J. Chromatogr. A. 12:(730):1996;115.
20. van Eijk H.M.H., Huinck M.P., Rooyakkers D.R., Deutz N.E.P. Automated simultaneous isolation and quantitation of labeled amino acid fractions from plasma and tissue by ion-exchange chromatography. J. Chromatogr. B Biomed. Appl. 660:1994;251.
21. Biolo G., Chinkes D., Zhang X.J., Wolfe R.R. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle. J. Parenter. Enter. Nutr. 16:1992;305.
22. Biolo G., Fleming R.Y., Maggi S.P., Wolfe R.R. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am. J. Physiol. 268:1995;E75.
23. Tourian A., Goddard J., Puck T.T. Phenylalanine hydroxylase activity in mammalian cells. J. Cell. Physiol. 73:1969;159.
24. Van der Hulst R.R.W.J., Kreel B.K., von Meyenfeldt M.F., Brummer R.J.M., Arends J.W., Deutz N.E.P., Soeters P.B. Glutamine and the preservation of gut integrity. Lancet. 341:1993;1363.
25. Norusis M.J. SPSS/PC + V4.0 Base Manual for the IBM PC/XT/AT and PS/2. 1989;SPSS Inc, Chicago.
26. Windmueller H.G., Spaeth A.E. Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Arch. Biochem. Biophys. 171:1975;662.
27. de Blaauw I., Van der Hulst R.R.W.J., Deutz N.E.P., von Meyenfeldt M.F. Glutamine depletion and increased gut permeability in non-anorectic, non weight losing tumor bearing rats. Gastroenterology. 112:1997;118.
28. Murch S.H., Braegger C.P., Walker Smith J.A., MacDonald T.T. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut. 34:1993;1705.
29. Wolfe R.R. Wolfe R.R. Tracers in Metabolic Research. 1992;A. R. Liss Inc, New York.
30. Lund J., Stjernstrom H., Vinnars E., Jorfeldt L., Bergholm U., Wiklund L. The influence of abdominal surgery on the splanchnic exchange of amino acids. Acta Chir. Scand. 152:1986;191.
31. Cruickshank A.M., Hansell D.T., Burns H.J., Shenkin A. Effect of nutritional status on acute phase protein response to elective surgery. Br. J. Surg. 76:1989;165.
32. Doherty J.F., Golden M.H., Raynes J.G., Griffin G.E., McAdam K.P. Acute-phase protein response is impaired in severely malnourished children. Clin. Sci. 84:1993;169.
33. Souba W.W., Wilmore D.W. Postoperative alteration of arteriovenous exchange of amino acids across the gastrointestinal tract. Surgery. 94:1983;342.
34. Deutz N.E.P., Reijven P.L., Athanasas G., Soeters P.B. Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs. Clin. Sci. 83:1992;607.
35. Souba W.W. Glutamine A key substrate for the splanchnic bed . Annu. Rev. Nutr. 11:1991;285.
36. Yao Y.M., Bahrami S., Leichtfried G., Redl H., Schlag G. Pathogenesis of hemorrhage-induced bacteria/endotoxin translocation in rats. Effects of recombinant bactericidal/permeability-increasing protein. Ann. Surg. 221:1995;398.
37. Wilmore D.W., Smith R.J., O'Dwyer S.T., Jacobs D.O., Ziegler T.R., Wang X.D. The gut A central organ after surgical stress . Surgery. 104:1988;917.
38. Hasselgren P.O., Fischer J.E. Counter-regulatory hormones and mechanisms in amino acid metabolism with special reference to the catabolic response in skeletal muscle. Curr. Opin. Clin. Nutr. Metab. Care. 2:1999;9.