Effect of total or partial uterus extirpation on uterus-projecting neurons in porcine inferior mesenteric ganglion: C. Changes in expression of apoptosis-associated (Bcl-2 and Bax) and regeneration-associated (GAP-43) proteins

Polish Journal of Veterinary Sciences

Volumn 6, Issue 2, 2003, Pages 161-172

  Wasowicz K ^a  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

Author keywords

Apoptosis; Axotomy; Extirpation; IMG; Pig; Regeneration; Uterus

Indexed keywords

FAST BLUE; FLUORESCENT DYE; NEUROMODULIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; ONCOPROTEIN; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; FLUORESCENCE; HYSTERECTOMY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFERIOR MESENTERIC GANGLION; NERVE FIBER; NERVE FIBER TRANSECTION; NERVE REGENERATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; UTERINE CERVIX; UTERUS; UTERUS HORN; ANIMAL; ANIMAL DISEASE; INNERVATION; MESENTERY; METABOLISM; NERVE CELL; SYMPATHETIC GANGLION;

ANIMALIA; SUIDAE; SUS SCROFA;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; DNA PRIMERS; FEMALE; GANGLIA, SYMPATHETIC; GAP-43 PROTEIN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MESENTERY; NEURONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; UTERUS;

EID: 0038486689     PISSN: 15051773     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Alm P, Bjorklund A, Owman C, Thorbert G (1979a) Tyrosine hydroxylase and DOPA decarboxylase activities in the guinea- pig uterus: further evidence for functional adrenergic denervation in association with pregnancy. Neuroscience 4: 145-154.
2. Alm P, Owman C, Sjoberg NO, Thorbert G (1979b) Uptake and metabolism of [3H]norepinephrine in uterine nerves of pregnant guinea pig. Am J Physiol 236: C277-C285.
3. Alm P, Lundberg LM, Wharton J, Polak JM (1988) Effects of pregnancy on the extrinsic innervation of the guinea pig uterus. A histochemical, immunohistochemical and ultrastructural study. Histochem J 20: 414-426.
4. Alonso G, Ridet JL, Oestreicher AB, Gispen WH, Privat A (1995) B-50 (GAP-43) immunoreactivity is rarely detected within intact catecholaminergic and serotonergic axons innervating the brain and spinal cord of the adult rat, but is associated with these axons following lesion. Exp Neurol 134: 35-48.
5. Antonsson B (2001) Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion. Cell Tissue Res 306: 347-361.
6. Baba N, Koji T, Itoh M, Mizuno A (1999) Reciprocal changes in the expression of Bcl-2 and Bax in hypoglossal nucleus after axotomy in adult rats: possible involvement in the induction of neuronal cell death. Brain Res 827: 122-129.
7. Bar-Peled O, Knudson M, Korsmeyer SJ, Rothstein JD (1999) Motor neuron degeneration is attenuated in bax-deficient neurons in vitro. J Neurosci Res 55: 542-556.
8. Bjerre B, Bjorklund A, Stenevi U (1973) Stimulation of growth of new axonal sprouts from lesioned monoamine neurones in adult rat brain by nerve growth factor. Brain Res 60: 161-176.
9. Chierzi S, Cenni MC, Maffei L, Pizzorusso T, Porciatti V, Ratto GM, Strettoi E (1998) Protection of retinal ganglion cells and preservation of function after optic nerve lesion in bcl-2 transgenic mice. Vision Res 38: 1537-1543.
10. de Bilbao F, Dubois-Dauphin M (1996) Time course of axotomy-induced apoptotic cell death in facial motoneurons of neonatal wild type and bcl-2 transgenic mice. Neuroscience 71: 1111-1119.
11. Deckwerth TL, Elliott JL, Knudson CM, Johnson-EM J, Snider WD, Korsmeyer SJ (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17: 401-411.
12. Deckwerth TL, Easton RM, Knudson CM, Korsmeyer SJ, Johnson EM (1998) Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol 152: 150-162.
13. Dubois-Dauphin M, Frankowski H, Tsujimoto Y, Huarte J, Martinou JC (1994) Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc Natl Acad Sci U S A 91: 3309-3313.
14. Easton RM, Deckwerth TL, Parsadanian AS, Johnson EM (1997) Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: a phenotype indistinguishable from Bax deletion. J Neurosci 17: 9656-9666.
15. Farlie PG, Dringen R, Rees SM, Kannourakis G, Bernard O (1995) bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc Natl Acad Sci U S A 92: 4397-4401.
16. Fu SY, Gordon T (1997) The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 14: 67-116.
17. Gillardon F, Wickert H, Zimmermann M (1994) Differential expression of bcl-2 and bax mRNA in axotomized dorsal root ganglia of young and adult rats. Eur J Neurosci 6: 1641-1644.
18. Gillardon F, Zimmermann M, Uhlmann E, Krajewski S, Reed JC, Klimaschewski L (1996) Antisense oligodeoxynucleotides to bax mRNA promote survival of rat sympathetic neurons in culture. J Neurosci Res 43: 726-734.
19. Groves MJ, Christopherson T, Giometto B, Scaravilli F (1997) Axotomy-induced apoptosis in adult rat primary sensory neurons. J Neurocytol 26: 615-624.
20. Haldar S, Jena N, Croce CM (1995) Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci U S A 92: 4507-4511.
21. Hendry IA (1976) Effects of axotomy on the trans-synaptic regulation of enzyme activity in adult rat superior cervical ganglia. Brain Res 107: 105-116.
22. Hendry IA (1992) Response of autonomic neurones to target deprivation: axotomy and regeneration. In: Hendry IA, Hill CE (eds) Development, regeneration and plasticity of the autonomic nervous system. Harwood Academic Publishers, Chur, pp 415-462.
23. Hill CE, Hendry IA, Ngu MC, van Helden DF (1985) Subpopulations of sympathetic neurones differ in their sensitivity to nerve growth factor antiserum. Brain Res 355: 121-130.
24. Hilton M, Middleton G, Davies AM (1997) Bcl-2 influences axonal growth rate in embryonic sensory neurons. Curr Biol 7: 798-800.
25. Hoffman PN (1989) Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons. J Neurosci 9: 893-897.
26. Hou XE, Lundmark K, Dahlstrom AB (1998) Cellular reactions to axotomy in rat superior cervical ganglia includes apoptotic cell death. J Neurocytol 27: 441-451.
27. Kaleczyc J, Timmermans JP, Majewski M, Łakomy M, Scheuermann DW (1999) Immunohistochemical properties of nerve fibers supplying accessory male genital glands in the pig. A co-localization study. Histochem Cell Biol 111: 217-228.
28. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53: 4701-4714.
29. Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6: 1389-1399.
30. Lundberg LM, Alm P, Carlen B (1987) S-100-immunoreactive nerves in the guinea-pig uterus with reference to ultrastructural correlations: effects of chemical sympathectomy and pregnancy. Cell Tissue Res 250: 241-249.
31. Martinou JC, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C (1994) Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13: 1017-1030.
32. Mathew TC, Miller FD (1993) Induction of T alpha 1 alpha-tubulin mRNA during neuronal regeneration is a function of the amount of axon lost. Dev Biol 158: 467-474.
33. Meiri KF, Pfenninger KH, Willard MB (1986) Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones. Proc Natl Acad Sci USA 83: 3537-3541.
34. Oppenheim RW, Prevette D, Tytell M, Homma S (1990) Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev Biol 138: 104-113.
35. Owman C (1981) Pregnancy induces degenerative and regenerative changes in the autonomic innervation of the female reproductive tract. Ciba Found Symp 83: 252-279.
36. Purves D, Thompson W (1979) The effect of post-ganglionic axotomy on selective synaptic connections in the superior cervical ganglion of the guinea-pig. J Physiol (Lond) 297: 95-110.
37. Rao MS, Landis SC (1990) Characterization of a target-derived neuronal cholinergic differentiation factor. Neuron 5: 899-910.
38. Rush RA, Saltis J, Smet PJ, Williams R (1992) Survival factors for autonomic neurones. In: Hendry IA, Hill CE (eds) Development, regeneration and plasticity of the autonomic nervous system. Harwood Academic Publishers, Chur, pp 305-364.
39. Schmidt RE, McAtee SJ, Plurad DA, Parvin CA, Cogswell BE, Roth KA (1988) Differential susceptibility of prevertebral and paravertebral sympathetic ganglia to experimental injury. Brain Res 460: 214-226.
40. Schotzinger RJ, Landis SC (1988) Cholinergic phenotype developed by noradrenergic sympathetic neurons after innervation of a novel cholinergic target in vivo. Nature 335: 637-639.
41. Skene JH, Willard M (1981) Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems. J Cell Biol 89: 96-103.
42. Vestergaard S, Tandrup T, Jakobsen J (1997) Effect of permanent axotomy on number and volume of dorsal root ganglion cell bodies. J Comp Neurol 388: 307-312.
43. Voyvodic JT (1992) Development and ongoing regulation of synaptic connections and neuronal morphology in autonomic ganglia. In: Hendry IA, Hill CE (eds) Development, regeneration and plasticity of the autonomic nervous system. Harwood Academic Publishers, Chur, pp 383-414.
44. Wa̧sowicz K (2003a) The effect of total or partial uterus extirpation on the uterus-projecting neurons in the porcine inferior mesenteric ganglion (IMG). A. Changes in the expression of transmitter-synthesizing enzymes - tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and choline acetyltransferase (ChAT). Pol J Vet Sci 6: 131-145.
45. Wa̧owicz K (2003b) The effect of total or partial uterus extirpation on the uterus-projecting neurons in the porcine inferior mesenteric ganglion (IMG). B. Changes in the expression of neuropeptide Y, galanin, vasoactive intestinal polypeptide, pituitary adenylate cyclase activating peptide, somatostatin and substance P. Pol J Vet Sci 6: 147-160.
46. Wa̧sowicz K, Majewski M, Łakomy M (1998) Distribution of neurons innervating the uterus of the pig. J Auton Nerv Syst 74: 13-22.
47. Whittemore SR, Larkfors L, Ebendal T, Holets VR, Ericsson A, Persson H (1987) Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions. J Neurosci 7: 244-251.
48. Windebank AJ, Blexrud MD (1989) Biological activity of a new neuronal growth factor from injured peripheral nerve. Brain Res Dev Brain Res 49: 243-251.
49. Yamada M (1988) Changes in the innervation of the uterus during pregnancy and following parturition. Histochemical and electron microscopic observations in rat and humans. Nippon Sanka Fujinka Gakkai Zasshi 40: 145-152.
50. Zaimis E, Berk L, Callingham BA (1965) Morphological, biochemical and functional changes in the sympathetic nervous system of rats treated with nerve growth factor-antiserum. Nature 206: 1220-1222.
51. Zhang H, Heim J, Meyhack B (1998) Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway. Biochem Biophys Res Commun 251: 454-459.
52. Zoubina EV, Smith PG (2000) Axonal degeneration and regeneration in rat uterus during the estrous cycle. Auton Neurosci 84: 176-185.
53. Zuber MX, Goodman DW, Karns LR, Fishman MC (1989) The neuronal growth-associated protein GAP-43 induces filopodia in non-neuronal cells. Science 244: 1193-1195.