Gγ subunit-selective G protein β5 mutant defines regulators of G protein signaling protein binding requirement for nuclear localization

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12507-12512

  Rojkova, Alexandra M ^a   Woodard, Geoffrey E ^a   Huang, Tzu Chuan ^c   Combs, Christian A ^b   Zhang, Jian Hua ^a   Simonds, William F ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; LASER BEAM EFFECTS; MICROSCOPIC EXAMINATION; MUTAGENESIS;

PROTEIN SIGNALING;

PROTEINS;

GUANINE NUCLEOTIDE BINDING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; PHOSPHOLIPASE C; PROTEIN SUBUNIT; RGS PROTEIN; GNB5 PROTEIN, HUMAN; GNB5 PROTEIN, RAT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; RGS7 PROTEIN, HUMAN; RGS7 PROTEIN, MOUSE; RGS7 PROTEIN, RAT; SIGNAL PEPTIDE;

ARTICLE; CELL FRACTIONATION; CELL NUCLEUS; CELL STRAIN; CONFOCAL LASER MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NERVE CELL; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CYTOLOGY; CYTOSOL; GENE EXPRESSION; GENETICS; KIDNEY; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; CYTOSOL; GENE EXPRESSION; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEINS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PC12 CELLS; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; RATS; RGS PROTEINS; TRANSFECTION;

EID: 0038485601     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207302200     Document Type: Article

References (48)

1. Dessauer, C. W., Posner, B. A., and Gilman, A. G. (1996) Clin. Sci. (Colch.) 91, 527-537
2. Watson, A. J., Katz, A., and Simon, M. I. (1994) J. Biol. Chem. 269, 22150-22156
3. Watson, A. J., Aragay, A. M., Slepak, V. Z., and Simon, M. I. (1996) J. Biol. Chem. 271, 28154-28160
4. Zhang, S. Y., Coso, O. A., Lee, C. H., Gutkind, J. S., and Simonds, W. F. (1996) J. Biol. Chem. 271, 33575-33579
5. Fletcher, J. E., Lindorfer, M. A., DeFilippo, J. M., Yasuda, H., Guilmard, M., and Garrison, J. C. (1998) J. Biol. Chem. 273, 636-644
6. Yoshikawa, D. M., Hatwar, M., and Smrcka, A. V. (2000) Biochemistry 39, 11340-11347
7. Lindorfer, M. A., Myung, C. S., Savino, Y., Yasuda, H., Khazan, R., and Garrison, J. C. (1998) J. Biol. Chem. 273, 34429-34436
8. Maier, U., Babich, A., Macrez, N., Leopoldt, D., Gierschik, P., Illenberger, D., and Nürnberg, B. (2000) J. Biol. Chem. 275, 13746-13754
9. Snow, B. E., Krumins, A. M., Brothers, G. M., Lee, S. F., Wall, M. A., Chung, S., Mangion, J., Arya, S., Gilman, A. G., and Siderovski, D. P. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13307-13312
10. Snow, B. E., Betts, L., Mangion, J., Sondek, J., and Siderovski, D. P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6489-6494
11. Posner, B. A., Gilman, A. G., and Harris, B. A. (1999) J. Biol. Chem. 274, 31087-31093
12. Zhang, J. H., and Simonds, W. F. (2000) J. Neurosci. 20, 1-5
13. Cabrera, J. L., De Freitas, F., Satpaev, D. K., and Slepak, V. Z. (1998) Biochem. Biophys. Res. Commun. 249, 898-902
14. Levay, K., Cabrera, J. L., Satpaev, D. K., and Slepak, V. Z. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2503-2507
15. Witherow, D. S., Wang, Q., Levay, K., Cabrera, J. L., Chen, J., Willars, G. B., and Slepak, V. Z. (2000) J. Biol. Chem. 275, 24872-24880
16. Jones, M. B., and Garrison, J. C. (1999) Anal. Biochem. 268, 126-133
17. Zhang, J. H., Barr, V. A., Mo, Y., Rojkova, A. M., Liu, S., and Simonds, W. F. (2001) J. Biol. Chem. 276, 10284-10289
18. Genetics Computer Group (1994) Program Manual for the Wisconsin Package, Version 8, Genetics Computer Group, Madison, WI
19. Jones, P. G., Lombardi, S. J., and Cockett, M. I. (1998) Biochim. Biophys. Acta 1402, 288-291
20. Ryan, J. C., Crouch, R. K., and Ma, J. X. (2001) Mol. Vis. 7, 222-227
21. van der Linden, A. M., Simmer, F., Cuppen, E., and Plasterk, R. H. (2001) Genetics 158, 221-235
22. Robatzek, M., Niacaris, T., Steger, K., Avery, L., and Thomas, J. H. (2001) Curr. Biol. 11, 288-293
23. Chase, D. L., Patikoglou, G. A., and Koelle, M. R. (2001) Curr. Biol. 11, 222-231
24. Wilson, I. A., Niman, H. L., Houghten, R. A., Cherenson, A. R., Connolly, M. L., and Lerner, R. A. (1984) Cell 37, 767-778
25. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
26. Simonds, W. F., Butrynski, J. E., Gautam, N., Unson, C. G., and Spiegel, A. M. (1991) J. Biol. Chem. 266, 5363-5366
27. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467
28. Towbin, H., Staehelin, T., and Gordon, J. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 4350-4354
29. Berridge, M. J., Dawson, R. M., Downes, C. P., Heslop, J. P., and Irvine, R. F. (1983) Biochem. J. 212, 473-482
30. Barr, V. A., Lane, K., and Taylor, S. I. (1999) J. Biol. Chem. 274, 21416-21424
31. Wall, M. A., Coleman, D. E., Lee, E., Iñiguez-Lluhi, J. A., Posner, B. A., Gilman, A. G., and Sprang, S. R. (1995) Cell 83, 1047-1058
32. Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E., and Sigler, P. B. (1996) Nature 379, 311-319
33. Sondek, J., Bohm, A., Lambright, D. G., Hamm, H. E., and Sigler, P. B. (1996) Nature 379, 369-374
34. Burkhard, P., Stetefeld, J., and Strelkov, S. V. (2001) Trends Cell Biol. 11, 82-88
35. Kovoor, A., Chen, C. K., He, W., Wensel, T. G., Simon, M. I., and Lester, H. A. (2000) J. Biol. Chem. 275, 3397-3402
36. Zhang, J. H., Lai, Z. N., and Simonds, W. F. (2000) J. Neurochem. 75, 393-403
37. Asano, T., Morishita, R., Ohashi, K., Nagahama, M., Miyake, T., and Kato, K. (1995) J. Neurochem. 64, 1267-1273
38. Patikoglou, G. A., and Koelle, M. R. (2002) J. Biol. Chem. 277, 47004-47013
39. Takei, Y., Kurosu, H., Takahashi, K., and Katada, T. (1992) J. Biol. Chem. 267, 5085-5089
40. Crouch, M. F., and Simson, L. (1997) FASEB J. 11, 189-198
41. Makkerh, J. P., Dingwall, C., and Laskey, R. A. (1996) Curr. Biol. 6, 1025-1027
42. Chatterjee, T. K., and Fisher, R. A. (2000) J. Biol. Chem. 275, 24013-24021
43. Heximer, S. P., Lim, H., Bernard, J. L., and Blumer, K. J. (2001) J. Biol. Chem. 276, 14195-14203
44. Song, L., Zmijewski, J. W., and Jope, R. S. (2001) Biochem. Biophys. Res. Commun. 283, 102-116
45. Burgon, P. G., Lee, W. L., Nixon, A. B., Peralta, E. G., and Casey, P. J. (2001) J. Biol. Chem. 276, 32828-32834
46. Dulin, N. O., Pratt, P., Tiruppathi, C., Niu, J., Voyno-Yasenetskaya, T., and Dunn, M. J. (2000) J. Biol. Chem. 275, 21317-21323
47. Chatterjee, T. K., and Fisher, R. A. (2000) J. Biol. Chem. 275, 29660-29671
48. Benzing, T., Yaffe, M. B., Arnould, T., Sellin, L., Schermer, B., Schilling, B., Schreiber, R., Kunzelmann, K., Leparc, G. G., Kim, E., and Walz, G. (2000) J. Biol. Chem. 275, 28167-28172