Diazepam as a Treatment for Metronidazole Toxicosis in Dogs: A Retrospective Study of 21 Cases

Journal of Veterinary Internal Medicine

Volumn 17, Issue 3, 2003, Pages 304-310

  Evans, Jason ^a   Levesque, Donald ^a   Knowles, Kim ^b   Longshore, Randy ^b   Plummer, Scott ^b  

^a Veterinary Neurological Center   (United States)

^b Veterinary Neurological Center   (United States)

Author keywords

aminobutyric acid; Benzodiazepine; Cerebellar disease; Drug toxicity; Vestibular syndrome

Indexed keywords

4 AMINOBUTYRIC ACID; DIAZEPAM; ANTICONVULSIVE AGENT; ANTIINFECTIVE AGENT; METRONIDAZOLE;

ARTICLE; BOLUS INJECTION; CLINICAL FEATURE; CLINICAL PROTOCOL; DRUG INTOXICATION; DRUG MECHANISM; INTERMETHOD COMPARISON; MEDICAL RECORD; NONHUMAN; REACTION TIME; RETROSPECTIVE STUDY; SPECIES COMPARISON; VESTIBULAR SYSTEM; AGING; ANIMAL; CENTRAL NERVOUS SYSTEM DISEASE; CHEMICALLY INDUCED DISORDER; DOG; FEMALE; HUMAN; MALE;

CANIS FAMILIARIS;

AGING; ANIMALS; ANTI-INFECTIVE AGENTS; ANTICONVULSANTS; CENTRAL NERVOUS SYSTEM DISEASES; DIAZEPAM; DOGS; FEMALE; HUMANS; MALE; METRONIDAZOLE; RETROSPECTIVE STUDIES;

EID: 0038482139     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/0891-6640(2003)017<0304:DAATFM>2.3.CO;2     Document Type: Article

References (52)

1. Finegold SM. Metronidazole. Ann Intern Med 1980;93:585-587.
2. Johnson G. Giardiasis. In: Kirk RW, ed. Current Veterinary Therapy VI. Philadelphia, PA: WB Saunders; 1977:969.
3. Garvey MS, Aucoin DP. Therapeutic strategies involving antimicrobial treatment of disseminated bacterial infection in small animals. J Am Vet Med Assoc 1984;185:1185-1189.
4. Dow SW, Jones RL, Adney WA. Anaerobic infections in dogs and cats and response to treatment: 36 cases (1985-1986). J Am Vet Med Assoc 1986;189:930-934.
5. Tams TR. Feline inflammatory bowel disease. In: Kirk RW, ed. Current Veterinary Therapy IX. Philadelphia, PA: WB Saunders; 1986: 884.
6. Rosenblatt JE, Edson RS. Metronidazole. Mayo Clin Proc 1983; 58:1564-1570.
7. Kusumi RK, Plouffe JF, Wyatt RH, et al. Central nervous system toxicity associated with metronidazole therapy. Ann Intern Med 1980; 93:59.
8. Dow SW, LeCouter RA, Poss ML, Beadleston D. Central nervous system toxicosis associated with metronidazole treatment of dogs: Five cases (1984-1987). J Am Vet Med Assoc 1989;195:365-368.
9. Fitch R, Moore M, Roen D. A warning to clinicians: Metronidazole neurotoxicity in a dog. Prog Vet Neurol 1991;2:307-309.
10. Saxon B, Magne M. Reversible central nervous system toxicosis associated with metronidazole therapy in three cats. Prog Vet Neurol 1993;4:25-27.
11. Caylor KB, Cassimatis MK. Metronidazole neurotoxicosis in two cats. J Am Anim Hosp Assoc 2001;37:258-262.
12. Dow SW. Management of anaerobic infections. Vet Clin North Am 1988;186:1167-1181.
13. McClure JA, Lycett P, Baskerville JC. Diazepam as an anti-motion sickness drug. J Otolaryngol 1982;4:253-259.
14. McClure JA, Willett JM. Lorazepam and diazepam in the treatment of benign paroxysmal vertigo. J Otolaryngol 1980;6:472-477.
15. Uchide K, Suzuki N, Takiguchi T, et al. The possible effect of pregnancy on Meniere's disease. J Otorhinolaryngol Relat Spec 1997; 59:292-295.
16. Matsuoka I, Chikamori Y, Takaori S, Morimoto M. Effects of chlorpromazine and diazepam on neuronal activities of the lateral vestibular nucleus in cats. Arch Otorhinolaryngol 1975;209:89-95.
17. Pettorossi VE, Troiani D, Petrosini L. Diazepam enhances cerebellar inhibition on vestibular neurons. Acta Otolaryngol 1982;93: 363-373.
18. Matsuoka I, Takahashi H, Sasa M, Takaori S. Experimental vestibular pharmacology: A minireview with special reference to neuroactive substances and antivertigo drugs. Acta Otolaryngol 1984; 419(Suppl):62-70.
19. Barmack NH, Pettorossi VE. The influence of diazepam on the activity of secondary vestibular neurons in the rabbit. Neurosci Lett 1980;16:33-44.
20. Ryu JH, McCabe BF. Effects of diazepam and dimenhydrinate on the resting activity of the vestibular neuron. Aerospace Med 1974; 10:1117.
21. Steiner FA, Felix D. Antagonistic effects of GABA and benzodiazepines on vestibular and cerebellar neurons. Nature 1976;260: 346.
22. Overall KL. Fears and phobias - Dogs. In: Tiley LP, Smith FWK, ed. The Five-Minute Veterinary Consult. Baltimore, MD: Williams & Wilkins; 1997:66-67.
23. Polzin DJ, Osborne CA. Diseases of the urinary tract. In: Davis LE, ed. Handbook of Small Animal Therapeutics. New York, NY: Churchill Livingstone; 1985:333-395.
24. Cochrane SM. Geriatric vestibular disease. In: Tiley LP, Smith FWK, ed. The Five-Minute Veterinary Consult. Baltimore, MD: Williams & Wilkins; 1997:1150-1151.
25. MacDonald RL, McLean MJ. Cellular basis of barbiturate and phenytoin anticonvulsant drug action. Epilepsia 1982;23:s7-s18.
26. b receptors. Trends Pharmacol Sci 1993;14:259-261.
27. Bloom F. Neurotransmission and the central nervous system. In: Hardman JG, Limbird LE, ed. Pharmacological Basis for Therapeutics, 9th ed. New York, NY: McGraw Hill; 1996:267-293.
28. Martin J, Gilchrist DP, Smith PF, Darlington CL. Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous nystagmus in guinea pig. J Vestib Res 1996;6:135-139.
29. Ishikawa K, Igarashi M. Effect of diazepam on vestibular compensation in squirrel monkeys. Arch Otorhinolaryngol 1984;240:49-54.
30. Scharer K. Selective Purkinje-Zellschadigungen nach oraler Verabreichung grosser Dosen von Nitroimidazol-Derivaten am Hund. Verh Dtsch Ges Pathol 1972;56:407-410.
31. Rogulja PV, Kovac W, Schmid H. Metronidazol-Encephalopathie der Ratt. Acta Neuropathol (Berl) 1973;25:36-45.
32. Jenkins TW. Functional Mammalian Neuroanatomy, 2nd ed. Philadelphia, PA: Lea & Febiger; 1978:238-251.
33. DeLahunta A. Veterinary Neuroanatomy and Clinical Neurology, 2nd ed. Philadelphia, PA: WB Saunders; 1983:255-278.
34. Chan-Palay V, Palay SL, Wu JY. Gamma amino butyric acid pathways in the cerebellum studied by retrograde and anterograde transport of glutamic decarboxylase antibody after in vivo injections. Anat Embryol 1979;157:1.
35. Henneman E. The cerebellum. In: Mountcastle VB, ed. Medical Physiology, 13th ed. St Louis, MO: CV Mosby; 1974:633-655.
36. b receptor pharmacology. Annu Rev Pharmacol Toxicol 1993;33:109-147.
37. Otsuka M. Gamma amino butyric acid and some other transmitter candidates in the nervous system. In: Acheson GH, Bloom FE, ed. Pharmacology and the Future of Man. Proceedings of the Fifth International Congress on Pharmacology, San Francisco, CA, 1973;4: 186-201.
38. a receptor shows a ligand-gated receptor superfamily. Nature 1987;328:221-227.
39. Pritchett DB, Sonthiemer H, Shivers BD, et al. Importance of a novel GABAa receptor subunit for benzodiazepine pharmacology. Nature 1989;338:582-585.
40. a receptor subtypes: From pharmacology to molecular biology. FASEB J 1991;5:2916-2923.
41. Gardner CR. Functional in vivo correlates of the benzodiazepine agonist-inverse agonist continuum. Prog Neurobiol 1988;31:425-476.
42. Semel JD, Allen N. Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. South Med J 1991;84:465-468.
43. Potokar J, Nutt DJ. Anxiolytic potential of benzodiazepines receptor partial agonists. CNS Drugs 1994;1:305-315.
44. Haefely W. Antagonists of benzodiazepines: Functional aspects. Adv Biochem Psychopharmacol 1983;38:73-93.
45. Roncari G, Timm U, Zell M, et al. Flumazenil kinetics in the elderly. Eur J Clin Pharmacol 1993;45:585-587.
46. Brogden RN, Goa KL. Flumazenil: A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use. Drugs 1988;35:448-467.
47. Hoffman EJ, Warren EW. Flumazenil: A benzodiazepine antagonist. Clin Pharmacol 1993;12:814-828.
48. Cohen B, DeJong JMBV. Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blinded study. Arch Neurol 1972;27:129-135.
49. Mandell GL, Petri WA. Penicillins, cephalosporins and other beta-lactam antibiotics. In: Hardman JG, Limbird LE, ed. Pharmacological Basis for Therapeutics, 9th ed. New York, NY: McGraw Hill; 1996:1073-1101.
50. Fingeroth JM. Treatment of canine intervertebral disk disease: Recommendations and controversies. In: Kirk RW, ed. Current Veterinary Therapy XII. Philadelphia, PA: WB Saunders; 1995:1148.
51. Jenkins WL. Pharmacological aspects of analgesic drugs in animals: An overview. J Am Vet Med Assoc 1987;191:1231-1240.
52. Lau AH, Lam NP, Piscitelli SC, et al. Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. Clin Pharmacokinet 1992;23:328-364.