Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous nystagmus in guinea pig

Journal of Vestibular Research: Equilibrium and Orientation

Volumn 6, Issue 2, 1996, Pages 135-139

  Martin, Jacelyn ^a   Gilchrist, Darrin P D ^a   Smith, Paul F ^b   Darlington, Cynthia L ^a,c  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Benzodiazepines; Diazepam; Unilateral labyrinthectomy; Vestibular compensation

Indexed keywords

DIAZEPAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; LABYRINTHECTOMY; MALE; NONHUMAN; PRIORITY JOURNAL; VESTIBULAR DISORDER;

EID: 0029878017     PISSN: 09574271     EISSN: None     Source Type: Journal    
DOI: 10.3233/ves-1996-6208     Document Type: Article

References (26)

1. McCabe BF, Sekitani T, Ryu JH. Drug effects on postlabyrinthectomy nystagmus. Arch Otolaryngol. 1973;98:310-3.
2. Schaefer KP, Meyer DL. Compensation of vestibular lesions. In: Kornhuber HH, ed. Handbook of sensory physiology; Vol 6: Part 2. Berlin: Springer-Verlag; 1974:463-90.
3. Bernstein P, McCabe BF, Ryu JH. The effect of diazepam on vestibular compensation. Laryngoscope. 1973;80:267-72.
4. Baloh RW. Approach to the dizzy patient. In: Baloh R, ed. Bailliere's Clin Neurol. 1994;3:453-65.
5. Blair SM, Gavin M. Modification of vestibulo-ocular reflex induced in the macaque by diazepam. Arch Otolaryngol. 1979;105:698-701.
6. Padoan S, Korttila K, Magnusson M, Pyykko I, Schalen L. Reduction of gain and time constant of vestibulo-ocular reflex in man induced by diazepam and thiopental. J Vest Res. 1990;1:97-104.
7. Sekitani T, McCabe BF, Ryu JH. Drug effects on the medial vestibular nucleus. Arch Otolaryngol. 1971; 93:581-9.
8. Ryu JH, McCabe BR Effects of diazepam and dimenhydrinate on the resting activity of the vestibular neuron. Aerospace Med. 1974;45:1117-29.
9. Zanni M, Giardino L, Toschi L, Galetti G, Calza L. Distribution of neurotransmitters, neuropeptides, and receptors in the vestibular nuclei complex of the rat: an immunocytochemical, in situ hybridization and quantitative receptor autoradiographic study. Brain Res Bull. 1995;36:443-52.
10. Hutchinson M, Darlington CL, Smith PF. The effects of long-term, low dose diazepam administration on guinea pig righting reflex latency and medial vestibular nucleus neuronal activity. Pharmacol Biochem Behav. 1995;50:665-9.
11. Smith PF, Darlington CL. The pharmacology of the vestibular system. In: Baloh R, ed. Bailliere's Clin Neurol. 1994;3:467-84.
12. de Waele C, Muhlethaler M, Vidai PP. Neurochemistry of the central vestibular pathways. Brain Res Rev. 1995;20:24-46.
13. Woods JH, Katz JL, Winger G. Benzodiazepines: use, abuse and consequences. Pharmacol Rev. 1992;44: 151-347.
14. Peppard SB. Effect of drug therapy on compensation from vestibular injury. Laryngoscope. 1986;96: 878-98.
15. Flohr H, Luneburg U. Neurotransmitter and neuromodulator systems involved in vestibular compensation. In: Berthoz A, Melvill Jones G, eds. Adaptive mechanisms in gaze control. Amsterdam: Elsevier; 1985:269-77.
16. Dieringer N, Precht W. Mechanism of compensation for vestibular deficits in the frog; 2: Modifications of the inhibitory pathways. Exp Brain Res. 1979;36: 329-41.
17. Thompson GC, Igarashi M, Cortez AM. GABA imbalance in squirrel monkey after unilateral vestibular end-organ ablation. Brain Res. 1986;370:182-5.
18. Calza L, Giardino L, Zanni M, Galetti R, Parchi P, Galetti G. Involvement of cholinergic and GABAergic systems in vestibular compensation. In: Lacour M, Toupet M, Denise P, Christen Y, eds., Vestibular compensation: facts, theories and clinical perspectives. Paris: Elsevier;1989:189-99.
19. Scott SJ, Smith PF, Darlington CL. Quantification of the depressive effects of diazepam on the guinea pig righting reflex. Pharmacol Biochem Behav. 1994; 47:739-41.
20. Smith PF, Darlington CL. Rapid tolerance to the depressive effects of diazepam on guinea pig motor control using divided doses. Pharmacol Biochem Behav. 1994;48:535-8.
21. Sansom AJ, Smith PF, Darlington CL. Fentazin anesthesia for labyrinthine surgery in guinea pigs. J Vest Res. [In press].
22. Gilchrist DPD, Darlington CL, Smith PF. A dose-response analysis of the beneficial effects of the ACTH-(4-9) analogue, Org 2766, on behavioural recovery following unilateral labyrinthectomy in guinea pig. Brit J Pharmacol. 1994;111:358-63.
23. Flohr H, Luneburg U. Effects of ACTH-(4-10) on vestibular compensation. Brain Res. 1982;248:169-73.
24. Maclenann K, Smith PF, Darlington CL. Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pig. Exp Neurol. 1995;131:273-8.
25. Snedecor GW, Cochran WG. Statistical methods. 8th ed. Ames, Iowa: Iowa State University Press.
26. Klotz U, Antonin KH, Bieck PR. Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat. J Pharmacol Exp Therap. 1976;199:67-73.