Clinical significance of bone marrow micrometastasis detected by nested RT-PCR for keratin-19 in breast cancer patients

Japanese Journal of Clinical Oncology

Volumn 33, Issue 4, 2003, Pages 167-172

  Jung, Yong Sik ^a   Lee, Kug Jong ^a   Kim, Hye Jin ^a   Yim, Hyun Ee ^a   Park, Joon Seong ^a   Soh, Euy Young ^a   Kim, Myung Wook ^a   Park, Hee Boong ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Breast carcinoma; Keratin 19; Micrometastasis; Nested RT PCR; Recurrence

Indexed keywords

KERATIN; MESSENGER RNA;

ARTICLE; BONE MARROW BIOPSY; BONE MARROW METASTASIS; BREAST CANCER; BREAST SURGERY; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MICROMETASTASIS; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; TISSUE DISTRIBUTION; BONE MARROW; BONE MARROW CANCER; BREAST TUMOR; CHEMISTRY; DISEASE FREE SURVIVAL; GENETICS; METASTASIS; METHODOLOGY; PAGET NIPPLE DISEASE; PATHOLOGY; PROGNOSIS; SENSITIVITY AND SPECIFICITY;

BONE MARROW; BONE MARROW NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KERATINS; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 0038470912     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyg038     Document Type: Article

References (28)

1. Schlimok G, Funke I, Holzmann B, Gottlinger G, Schmidt G, Hauser H, et al. Micrometastatic cancer cells in bone marrow: In vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies. Proc Natl Acad Sci USA 1987;84:8672-6.
2. Raj GV, Moreno JG, Gomella LG. Utilization of polymerase chain reaction technology in the detection of solid tumors. Cancer 1998;82:1419-42.
3. De Vita VT. Breast cancer therapy: Exercising all our options. N Engl J Med 1989;320:527-9.
4. Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 2000;342:525-33.
5. Mansi JL, Gogas H, Bliss JM, Gazet JC, Berger U, Coombes RC. Outcome of primary-breast-cancer patients with micrometastasis: A long-term follow-up. Lancet 1999;354:197-202.
6. Pantel K, Cote RJ, Fodstad O. Detection and clinical importance of micrometastic disease. J Natl Cancer Inst 1999;91:1113-24.
7. Hellman S. Stopping metastases at their source. N Engl J Med 1997;337: 996-7.
8. Racila E, Euhus D, Weiss AJ, Rao C, McConnell J, Terstappen LWMM, et al. Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci USA 1998;95:4589-94.
9. Dearnaley DP, Sloane JP, Ormerod MG, Steele K, Coombes RC, Clink HM, et al. Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen. Br J Cancer 1981; 44:85-90.
10. Redding WH, Coombes RC, Monaghan P, Clink HM, Imrie SF, Dearnaley DP, et al. Detection of micrometastases in patients with primary breast cancer. Lancet 1983;2:1271-4.
11. Dearnaley DP, Ormerod MG, Sloane JP. Micrometastases in breast cancer: long-term follow-up of the first patient cohort. Eur J Cancer 1991;27:236-9.
12. Mansi JL, Easton D, Berger U, Gazet JC, Ford HT, Dearnaley D, et al. Bone marrow micrometastases in primary breast cancer: Prognostic significance after 6 years' follow-up. Eur J Cancer 1991;27:1552-5.
13. Schoenfeld A, Luqmani Y, Smith D, O'Reilly S, Shousha S, Sinnett HD, et al. Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction. Cancer Res 1994;54:2986-90.
14. Kruger W, Krzizanowski C, Holweg M, Stockschlader M, Kroger N, Jung R, et al. Reverse transcriptase/polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients. J Cancer Res Clin Oncol 1996;122:679-86.
15. Vannucchi AM, Bosi A, Glinz S, Pacini P, Linari S, Saccardi R, et al. Evaluation of breast tumour cell contamination in the bone marrow and leukapheresis collections by RT-PCR for cytokeratin-19 mRNA. Br J Haematol 1998;103:610-7.
16. Braun S, Cevatli BS, Assemi C, Janni W, Kentenich CR, Schindlbeck C, et al. Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy. J Clin Oncol 2001;19:1468-75.
17. Trummer A, Kadar J, Arseniev L, Petersen D, Ganser A, Lichtinghagen R. Competitive cytokeratin-19 RT-PCR for quantification of breast cancer cells in blood cell suspensions. J Hematother Stem Cell Res 2000;9:275-84.
18. Mitas M, Mikhitarian K, Walters C, Baron PL, Elliott BM, Brothers TE, et al. Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer 2001;93:162-71.
19. Ruud P, Fodstad O, Hovig E. Identification of a novel cytokeratin-19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells. Int J Cancer 1999;80:119-25.
20. Nasser IA, Lee AKC, Bosari S, Saganich R, Heatley G, Silverman ML. Occult axillary lymph node metastases in 'node-negative' breast carcinoma. Hum Pathol 1993;24:950-7.
21. Cote RJ, Peterson HF, Chaiwun B, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, et al. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. Lancet 1999;354:896-900.
22. McGuckin MA, Cummings MC, Walsh MD, Hohn BG, Bennett IC, Wright RG. Occult axillary node metastases in breast cancer: Their detection and prognostic significance. Br J Cancer 1996;73:88-95.
23. Wells C, Heryet A, Borchier J, Gatter KC, Mason DY. The immunocytochemical detection of axillary micrometastases in breast cancer. Br J Cancer 1984;50:193-8.
24. Battaglia M, Pedrazzoli P, Palermo B, Lanza A, Bertolini F, Gibelli N, et al. Epithelial tumor cell detection and the unsolved problems of nested RT-PCR: A new sensitive one step method without false positive results. Bone Marrow Transplant 1998;22:693-8.
25. Silva JM, Dominguez G, Silva J, Garcia JM, Sanchez A, Rodriguez O, et al. Detection of epithelial messenger RNA in the plasma of breast cancer patients is associated with poor prognosis tumor characteristics. Clin Cancer Res 2001;7:2821-5.
26. DeVita VT Jr, Rosenberg SA, Hellman S. Cancer: Principles and Practice of Oncology. 5th ed. New York: Lippincott-Raven 1997.
27. Watson MA, Fleming TP. Isolation of differentially expressed sequence tags from human breast cancer. Cancer Res 1994;54:4598-602.
28. Watson MA, Fleming TP. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. Cancer Res 1996;56:860-5.