Protein transduction by poly-arginine

Folia Pharmacologica Japonica

Volumn 121, Issue 6, 2003, Pages 435-439

  Matsui, Hideki ^a   Tomizawa, Kazuhito ^a   Matsushita, Masayuki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Polyarginine; Protein therapy; Protein transduction; PTD; TAT

Indexed keywords

HOMEODOMAIN PROTEIN; POLYARGININE; PROTEIN TRANSDUCTION DOMAIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANTENNA; ARTICLE; BRAIN SLICE; DROSOPHILA; DROSOPHILA ANTENNAPEDIA; DRUG DELIVERY SYSTEM; FORELIMB; HERPES SIMPLEX VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRACELLULAR SPACE; PROTEIN DOMAIN; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; EUKARYOTIC CELLS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC;

EID: 0038459347     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.121.435     Document Type: Article

References (15)

1. Frankel AD and Pabo CO: Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55, 1189-1193 (1988)
2. Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G and Prochiantz A: Cell inernalization of the third helix of antennapedia homeodomain is receptor-independent. J Biol Chem 271, 18188-18193 (1996)
3. Elliott G and O'Hare P: Intracellular trafficking and protein delivery by a herpesvirus structure protein. Cell 88, 223-233 (1997)
4. Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L and Rothbard JB: The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc Natl Acad Sci USA 97, 13003-13008 (2000)
5. Futaki S, Suzuki T, Ohashi W, Yagami T, Tanaka S, Ueda K and Sugiura Y: Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 276, 5836-5840 (2001)
6. Matsushita M, Tomizawa K, Moriwaki A, Li ST, Terada H and Matsui H: A high efficiency protein transduction system demonstrating the role of PKA in long lasting LTP. J Neuroci 21, 6000-6007 (2001)
7. Mai JC, Shen H, Watkins SC, Cheng T and Robbins PD: Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate. J Biol Chem 277, 30208-30218 (2002)
8. Suzuki T, Futaki S, Niwa M, Tanaka S, Ueda K and Sugiura Y: Possible existence of common internalization mechanisms among arginine-rich peptides. J Biol Chem 277, 2437-2443 (2002)
9. Tyagi M, Rusnati M, Presta M and Giacca M: Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276, 3254-3261 (2001)
10. Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A and He JJ: Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Med 6, 1380-1387 (2000)
11. Kip1 induces cell migration. Nature Med 4, 1449-1452 (1998)
12. Fang B, Xu B, Koch P and Roth JA: Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther 5, 1420-1424 (1998)
13. Matsui H, Tomizawa K, Lu YF and Matsushita M: Related Articles, Links Protein Therapy: in vivo protein transduction by polyarginine (11R) PTD and subcellular targeting delivery. Curr Protein Pept Sci 4 (2), 151-157 (2003)
14. Richard JP, Melikov K, Vives E, Ramos C, Verbeure B, Gait MJ, Chernomordik LV and Lebleu B: Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 278, 585-590 (2003)
15. Takenobu T, Tomizawa K, Matsushita M, Li ST, Moriwaki A, Lu YF and Matsui H: Development of p53 protein transduction therapy using membranepermeable peptides and the application to oral cancer cells. Mol Cancer Ther 1, 1043-1049 (2002)