A novel morphological technique to investigate a single climbing fibre synaptogenesis with a Purkinje cell in the developing mouse cerebellum: Dil injection into the inferior cerebellar peduncle

Journal of Electron Microscopy

Volumn 52, Issue 3, 2003, Pages 327-335

  Kiyohara, Yoshimoto ^a   Endo, Katsuaki ^a   Ide, Chizuka ^a   Mizoguchi, Akira ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b MIE UNIVERSITY   (Japan)

Author keywords

Anterograde tracing; Cerebellum; Multiple innervation; Pericellular nest; Photoconversion; Postnatal development

Indexed keywords

3,3' DIOCTADECYLINDOCARBOCYANINE; 3,3'-DIOCTADECYLINDOCARBOCYANINE; CARBOCYANINE; FLUORESCENT DYE;

ANIMAL; ARTICLE; CEREBELLUM; ELECTRON MICROSCOPY; EVALUATION; FLUORESCENCE MICROSCOPY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHODOLOGY; MOUSE; NERVE FIBER; NEWBORN; PHYSIOLOGY; PURKINJE CELL; SYNAPSE; ULTRASTRUCTURE;

ANIMALS; ANIMALS, NEWBORN; CARBOCYANINES; CEREBELLUM; FLUORESCENT DYES; MICE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; NERVE FIBERS; PURKINJE CELLS; SYNAPSES;

ANIMALIA;

BRAIN; CELLS; ELECTRON MICROSCOPES; ELECTRONS; FIBERS; INORGANIC COMPOUNDS; MAMMALS; NEURONS;

ANTEROGRADE TRACING; CEREBELLUM; CLIMBING FIBERS; MICROSCOPIC LEVELS; MULTIPLE INNERVATION; PERICELLULAR NEST; PHOTOCONVERSION; POSTNATAL DEVELOPMENT; PURKINJE CELLS; TRACING METHOD;

CYTOLOGY;

EID: 0038454488     PISSN: 00220744     EISSN: None     Source Type: Journal    
DOI: 10.1093/jmicro/52.3.327     Document Type: Article

References (25)

1. Köbbert C, Apps R, Bechmann I, Lanciego J L, Mey J, and Thanos S (2000) Current concepts in neuroanatomical tracing. Prog. Neurobiol. 62: 327-351.
2. Crepel F (1982) Regression of functional synapses in the immature mammalian cerebellum. Trends Neurosci. 5: 266-269.
3. Kakizawa S, Yamasaki M, Watanabe M, and Kano M (2000) Critical period for activity-dependent synapse elimination in developing cerebellum. J. Neurosci. 20: 4954-4961.
4. Ramón y Cajal S (1911) Histologie du Système Nerveux de l'Homme et des Vertébrés, vol. II. (Maloine, Paris.)
5. O'Leary J L, Inukai J, and Smith J M (1971) Histogenesis of the cerebellar climbing fiber in the rat. J. Comp. Neurol. 142: 377-391.
6. Mason C A, Christakos S, and Catalano S M (1990) Early climbing fiber interactions with Purkinje cells in the postnatal mouse cerebellum. J. Comp. Neurol. 297: 77-90.
7. Sugihara I, Wu H S, and Shinoda Y (1999) Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat. J. Comp. Neurol. 414: 131-148.
8. Kreitzer A C, Gee K R, Archer E A, and Regehr W G (2000) Monitoring presynaptic calcium dynamics in projection fibers by in vivo loading of a novel calcium indicator. Neuron 27: 25-32.
9. Sugihara I, Wu H S, and Shinoda Y (2001) The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to cerebellar compartmentalization. J Neurosci. 11: 7715-7723.
10. Ichikawa R, Miyazaki T, Kano M, Hashikawa T, Tatsumi H, Sakimura K, Mishina M, Inoue Y, and Watanabe M (2002) Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor δ2. J. Neurosci. 22: 8487-8503.
11. von Bartheld C S, Cunningham D E, and Rubel E W (1990) Neuronal tracing with DiI: decalcification, cryosectioning, and photoconversion for light and electron microscopic analysis. J. Histochem. Cytochem. 38: 725-733.
12. Linke R and Frotscher M (1993) Development of the rat septohippocampal projection: tracing with DiI and electron microscopy of identified growth cone. J. Comp. Neurol. 332: 69-88.
13. Tamamaki N (1999) Development of afferent fiber lamination in the infrapyramidal blade of the rat dentate gyrus. J Comp. Neurol. 411: 257-266.
14. Mason C A and Gregory E (1984) Postnatal maturation of cerebellar mossy and climbing fibers: transient expression of dual features on single axons. J. Neurosci 4: 1715-1735.
15. Altman J (1972) Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J. Comp. Neurol. 145: 399-464.
16. Palay S and Chan-Palay V (1974) Cerebellar Cortex: Cytology and Organization. (Springer, New York.)
17. Godement P, Vanselow J, Thanos S, and Bonhoeffer F (1987) A study in developing visual systems with a new method of staining neurones and their processes in fixed tissue. Development 101: 697-713.
18. Morara S, van der Want J J, de Weerd H, Provini L, and Rosina A (2001) Ultrastructural analysis of climbing fiber-Purkinje cell synaptogenesis in the rat cerebellum. Neuroscience 108: 655-671.
19. Fremeau R T, Jr, Troyer M D, Pahner I, Nygaard G O, Tran C H, Reimer R J, Bellocchio E E, Fortin D, Storm-Mathisen J, and Edwards R H (2001) The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 31: 247-260.
20. Kaneko T, Fujiyama F, and Hioki H (2002) Immunohistochemical localization of candidates for vesicular glutamate transporters in the rat brain. J. Comp. Neurol. 444: 39-62.
21. Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, Takayama C, Inoue Y, Kutsuwada T, Yagi T, Kang Y, Aizawa S, and Mishina M (1995) Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice. Cell 81: 245-252.
22. Kano M, Hashimoto K, Chen C, Abeliovich A, Aiba A, Kurihara H, Watanabe M, Inoue Y, and Tonegawa S (1995) Impaired synapse elimination during cerebellar development in PKCγ mutant mice. Cell 83: 1223-1231.
23. Kano M, Hashimoto K, Kurihara H, Watanabe M, Inoue Y, Aiba A, and Tonegawa S (1997) Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron 18: 71-79.
24. Offermanns S, Hashimoto K, Watanabe M, Sun W, Kurihara H, Thompson R F, Inoue Y, Kano M, and Simon M I (1997) Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq. Proc. Natl. Acad. Sci. USA 94: 14089-14094.
25. Kano M, Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H S, Inoue Y, Simon M I, and Wu D (1998) Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc. Natl. Acad. Sci. USA 95: 15724-15729.