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Volumn 12, Issue 7, 2003, Pages 1211-1225

Thalidomide: A new anticancer drug?

Author keywords

Angiogenesis; Anticancer therapy; Biological treatment; Thalidomide

Indexed keywords

ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CISPLATIN; CLARITHROMYCIN; CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; DACARBAZINE; DEXAMETHASONE; DOXORUBICIN; ETANERCEPT; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; INTERLEUKIN 1; INTERLEUKIN 2; IRINOTECAN; MELPHALAN; PACLITAXEL; PENTOXIFYLLINE; PROSTATE SPECIFIC ANTIGEN; RITUXIMAB; STEROID; TEMOZOLOMIDE; THALIDOMIDE; TOPOTECAN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VINBLASTINE;

EID: 0038445682     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.12.7.1211     Document Type: Review
Times cited : (38)

References (145)
  • 1
    • 47349113508 scopus 로고
    • Thalidomide and congenital abnormalities
    • (Letter)
    • MCBRIDE WG: Thalidomide and congenital abnormalities. Lancet (1961) 2:1358 (Letter).
    • (1961) Lancet , vol.2 , pp. 1358
    • McBride, W.G.1
  • 3
    • 0029548149 scopus 로고
    • Immunomodulation by thalidomide: Systematic review of the literature and of unpublished observations
    • ZWINGENBERGER K, WNENDT S: Immunomodulation by thalidomide: systematic review of the literature and of unpublished observations. J. Inflamm. (1995) 46:177-211.
    • (1995) J. Inflamm. , vol.46 , pp. 177-211
    • Zwingenberger, K.1    Wnendt, S.2
  • 5
    • 0032771855 scopus 로고    scopus 로고
    • Thalidomide in patients with cachexia due to terminal cancer: Preliminary report
    • BRUERA E, NEUMANN CM, PITUSKIN E, CALDER K, BALL G, HANSON J: Thalidomide in patients with cachexia due to terminal cancer: preliminary report. Ann. Oncol. (1999) 10:857-859.
    • (1999) Ann. Oncol. , vol.10 , pp. 857-859
    • Bruera, E.1    Neumann, C.M.2    Pituskin, E.3    Calder, K.4    Ball, G.5    Hanson, J.6
  • 6
    • 0035895104 scopus 로고    scopus 로고
    • Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
    • MOEHLER T, NEBEN K, BENNER A et al.: Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy. Blood (2001) 98:3846-3848.
    • (2001) Blood , vol.98 , pp. 3846-3848
    • Moehler, T.1    Neben, K.2    Benner, A.3
  • 7
    • 0036499274 scopus 로고    scopus 로고
    • Unexpected toxicity of combination thalidomide and interferon alfa-2a treatment in metastatic renal cell carcinoma
    • NATHAN P, GORE M, EISEN T: Unexpected toxicity of combination thalidomide and interferon alfa-2a treatment in metastatic renal cell carcinoma. J. Clin. Oncol. (2002) 20:1429-1430.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1429-1430
    • Nathan, P.1    Gore, M.2    Eisen, T.3
  • 8
    • 0032903830 scopus 로고    scopus 로고
    • Pharmacokinetics of thalidomide in an elderly prostate cancer population
    • FIGG WD, RAJE S, BAUER KS et al.: Pharmacokinetics of thalidomide in an elderly prostate cancer population. J. Pharm. Sci. (1999) 88:121-125.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 121-125
    • Figg, W.D.1    Raje, S.2    Bauer, K.S.3
  • 9
    • 0033954292 scopus 로고    scopus 로고
    • Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas
    • FINE HA, FIGG WD, JAECKLE K et al.: Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J. Clin. Oncol. (2000) 18:708-715.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 708-715
    • Fine, H.A.1    Figg, W.D.2    Jaeckle, K.3
  • 10
    • 0034905077 scopus 로고    scopus 로고
    • The revitalization of thalidomide
    • THOMAS DA, KANTARJIAN HM: The revitalization of thalidomide. Ann. Oncol. (2001) 12:885-886.
    • (2001) Ann. Oncol. , vol.12 , pp. 885-886
    • Thomas, D.A.1    Kantarjian, H.M.2
  • 11
    • 0035985945 scopus 로고    scopus 로고
    • Thalidomide, an antiangiogenic agent with clinical activity in cancer
    • NG SSW, BROWN M, FIGG WD: Thalidomide, an antiangiogenic agent with clinical activity in cancer. Biomed. Pharmacother. (2002) 56:194-199.
    • (2002) Biomed. Pharmacother. , vol.56 , pp. 194-199
    • Ng, S.S.W.1    Brown, M.2    Figg, W.D.3
  • 12
    • 0035139076 scopus 로고    scopus 로고
    • Effect of angiogenic and antiangiogenic compounds on the outgrowth of capillary structures from fetal mouse bone explants
    • DECKERS M, VAN DER PLUIJM G, DOOIJEWAARD S et al.: Effect of angiogenic and antiangiogenic compounds on the outgrowth of capillary structures from fetal mouse bone explants. Lab. Invest. (2001) 81:5-15.
    • (2001) Lab. Invest. , vol.81 , pp. 5-15
    • Deckers, M.1    Van Der Pluijm, G.2    Dooijewaard, S.3
  • 13
    • 0023789803 scopus 로고
    • A short history of thalidomide embryopathy
    • LENZ W: A short history of thalidomide embryopathy. Teratology (1988) 38:203-215.
    • (1988) Teratology , vol.38 , pp. 203-215
    • Lenz, W.1
  • 14
    • 0032100604 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by thalidomide requires metabolic activation wich is species-dependent
    • BAUER KS, DIXON SC, FIGG WD: Inhibition of angiogenesis by thalidomide requires metabolic activation wich is species-dependent. Biochem. Pharmacol. (1998) 55:1827-1834.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1827-1834
    • Bauer, K.S.1    Dixon, S.C.2    Figg, W.D.3
  • 15
    • 0034058818 scopus 로고    scopus 로고
    • Hypothesis: Thalidomide embryopathy-proposed mechanism of action
    • STEPHENS T, FILLMORE B: Hypothesis: thalidomide embryopathy-proposed mechanism of action. Teratology (2000) 61:189-195.
    • (2000) Teratology , vol.61 , pp. 189-195
    • Stephens, T.1    Fillmore, B.2
  • 17
    • 0035186865 scopus 로고    scopus 로고
    • Thalidomide and its analogues inhibit lipopolysaccharide-mediated induction of cyclooxygenase-2
    • FUJITA J, MESTRE JR, ZELDIS JB, SUBBARAMAIAH K, DANNEMBERG AJ: Thalidomide and its analogues inhibit lipopolysaccharide-mediated induction of cyclooxygenase-2. Clin. Cancer Res. (2001) 7:3349-3355.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3349-3355
    • Fujita, J.1    Mestre, J.R.2    Zeldis, J.B.3    Subbaramaiah, K.4    Dannemberg, A.J.5
  • 18
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • TSUJII M, KAWANO S, TSUJII S, SAWAOKA H, HORI M, DUBOIS RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell (1998) 93:705-716.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsujii, S.3    Sawaoka, H.4    Hori, M.5    Dubois, R.N.6
  • 19
    • 0033979545 scopus 로고    scopus 로고
    • Specific inhibition of cyclooxygenase-2 restores antitumor reactivity by alterating the balance of IL-10 and IL-12 synthesis
    • STOLINA M, SHARMA S, LIN Y et al.: Specific inhibition of cyclooxygenase-2 restores antitumor reactivity by alterating the balance of IL-10 and IL-12 synthesis. J. Immunol. (2000) 164:361-370.
    • (2000) J. Immunol. , vol.164 , pp. 361-370
    • Stolina, M.1    Sharma, S.2    Lin, Y.3
  • 21
    • 0032920168 scopus 로고    scopus 로고
    • Tumor necrosis factor is a survival and proliferation factor for human myeloma cells
    • JOURDAN M, TARTE K, LEGOUFFE E et al.: Tumor necrosis factor is a survival and proliferation factor for human myeloma cells. Eur. Cytokine Netw. (1999) 10:65-70.
    • (1999) Eur. Cytokine Netw. , vol.10 , pp. 65-70
    • Jourdan, M.1    Tarte, K.2    Legouffe, E.3
  • 22
    • 0025356050 scopus 로고
    • The role of interleukin-1 and tumour necrosis factor-alpha in human multiple myeloma
    • CARTER A, MERCHAV S, SILVIAN-DRAXLER I et al.: the role of interleukin-1 and tumour necrosis factor-alpha in human multiple myeloma. Br. J. Haematol. (1990) 74:424-431.
    • (1990) Br. J. Haematol. , vol.74 , pp. 424-431
    • Carter, A.1    Merchav, S.2    Silvian-Draxler, I.3
  • 23
    • 0027230553 scopus 로고
    • Thalidomide exerts its inhibitory action on tumor necrosis factor-alpha by enhancing mRNA degradation
    • MOREIRA A, SAMPAIO E, ZMUIDZINAS A, FINDT P, SMITH K, KAPLAN G: Thalidomide exerts its inhibitory action on tumor necrosis factor-alpha by enhancing mRNA degradation. J. Exp. Med. (1993) 177:1675-1680.
    • (1993) J. Exp. Med. , vol.177 , pp. 1675-1680
    • Moreira, A.1    Sampaio, E.2    Zmuidzinas, A.3    Findt, P.4    Smith, K.5    Kaplan, G.6
  • 24
    • 0029664920 scopus 로고    scopus 로고
    • Binding of thalidomide to α1-acid- glycoprotein may be involved in its inhibition of tumor necrosis factor production
    • TURK B, JIANG H, LILU J: Binding of thalidomide to α1-acid- glycoprotein may be involved in its inhibition of tumor necrosis factor production. Proc. Natl. Acad. Sci. USA (1996) 93:7552-7556.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7552-7556
    • Turk, B.1    Jiang, H.2    Lilu, J.3
  • 25
    • 0031846669 scopus 로고    scopus 로고
    • Interaction of thalidomide, phthalamide analogues of thalidomide and pentoxifylline with the antitumor agent 5,6-dimethylxanthenone-4-acetic acid: Cocomitant reduction of serum tumor necrosis factor-alpha and enhancement of antitumor activity
    • CHING L, BROWNE W, TCHERNEGOVSKI R: Interaction of thalidomide, phthalamide analogues of thalidomide and pentoxifylline with the antitumor agent 5,6-dimethylxanthenone-4-acetic acid: cocomitant reduction of serum tumor necrosis factor-alpha and enhancement of antitumor activity. Br. J. Cancer (1998) 78:336-343.
    • (1998) Br. J. Cancer , vol.78 , pp. 336-343
    • Ching, L.1    Browne, W.2    Tchernegovski, R.3
  • 26
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and I-κB proteins: New discoveries and insights
    • BALDWIN AS: The NF-κB and I-κB proteins: new discoveries and insights. Ann. Rev. Immunol. (1996) 14:649-683.
    • (1996) Ann. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 27
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
    • BALDWIN AS: Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J. Clin. Invest. (2001) 107:241-246.
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 28
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity by thalidomide trough suppression of I κB kinase activity
    • KEIFER JA, GUTTRIDGE DC, ASHBURNER BP, BALDWIN AS: Inhibition of NF-κB activity by thalidomide trough suppression of I κB kinase activity. J. Biol. Chem. (2001) 276:22382-22387.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin, A.S.4
  • 29
    • 0031573214 scopus 로고    scopus 로고
    • Inhibition of IL-12 production by thalidomide
    • MOLLER DR, WYSOCKA M, GREENLEE BM et al.: Inhibition of IL-12 production by thalidomide. J. Immunol. (1997) 159:5157-5161.
    • (1997) J. Immunol. , vol.159 , pp. 5157-5161
    • Moller, D.R.1    Wysocka, M.2    Greenlee, B.M.3
  • 30
    • 0031444981 scopus 로고    scopus 로고
    • Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis
    • MOREIRA AL, TSENOVA-BERKOVA L, WANG J et al.: Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. Tubercle Lung Dis. (1997) 78:47-55.
    • (1997) Tubercle Lung Dis. , vol.78 , pp. 47-55
    • Moreira, A.L.1    Tsenova-Berkova, L.2    Wang, J.3
  • 31
    • 0031669267 scopus 로고    scopus 로고
    • Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells
    • ROWLAND TL, MCHUGH SM, DEIGHTON J, DEARMAN RJ, EWAN PW, KIMBER I: Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells. Immunopharmacology (1998) 40:11-20.
    • (1998) Immunopharmacology , vol.40 , pp. 11-20
    • Rowland, T.L.1    Mchugh, S.M.2    Deighton, J.3    Dearman, R.J.4    Ewan, P.W.5    Kimber, I.6
  • 32
    • 0030746472 scopus 로고    scopus 로고
    • The metabolic and immunologic effects of short-term thalidomide treatment of patients infected with the human immunodeficiency virus
    • HASLETT P, HEMPSTEAD M, SEIDMAN C et al.: The metabolic and immunologic effects of short-term thalidomide treatment of patients infected with the human immunodeficiency virus. AIDS Res. Hum. Retrovir. (1997) 13:1047-1057.
    • (1997) AIDS Res. Hum. Retrovir. , vol.13 , pp. 1047-1057
    • Haslett, P.1    Hempstead, M.2    Seidman, C.3
  • 33
    • 0028807544 scopus 로고
    • Thalidomide increases the synthesis of IL-2 in cultures of human mononuclear cells stimulated with Concanavalin-A, Staphylococcal enterotoxin A, and purified protein derivative
    • SHANNON EJ, SANDOVAL F: Thalidomide increases the synthesis of IL-2 in cultures of human mononuclear cells stimulated with Concanavalin-A, Staphylococcal enterotoxin A, and purified protein derivative. Immunopharmacology (1995) 31:109-116.
    • (1995) Immunopharmacology , vol.31 , pp. 109-116
    • Shannon, E.J.1    Sandoval, F.2
  • 34
    • 0031947779 scopus 로고    scopus 로고
    • IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with Type II lepra reaction on thalidomide treatment
    • PARTIDA-SANCHEZ S, FAVILA-CASTILLO L, PEDRAZA-SANCHEZ S et al.: IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with Type II lepra reaction on thalidomide treatment. Int. Arch. Allergy Immunol. (1998) 116:60-66.
    • (1998) Int. Arch. Allergy Immunol. , vol.116 , pp. 60-66
    • Partida-Sanchez, S.1    Favila-Castillo, L.2    Pedraza-Sanchez, S.3
  • 35
    • 0032100486 scopus 로고    scopus 로고
    • Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset
    • HASLETT PA, CORRAL LG, ALBERT M, KAPLAN G: Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. J. Exp. Med. (1998) 187:1885-1892.
    • (1998) J. Exp. Med. , vol.187 , pp. 1885-1892
    • Haslett, P.A.1    Corral, L.G.2    Albert, M.3    Kaplan, G.4
  • 36
    • 0036381106 scopus 로고    scopus 로고
    • Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during costimulation of both CD4+ and CD8+ T cells
    • MARRIOTT JB, CLARKE IA, DREDGE K, MULLER G, STIRLING D, DALGLEISH A: Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during costimulation of both CD4+ and CD8+ T cells. Clin. Exp. Immunol. (2002) 130:75-84.
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 75-84
    • Marriott, J.B.1    Clarke, I.A.2    Dredge, K.3    Muller, G.4    Stirling, D.5    Dalgleish, A.6
  • 37
    • 0034072592 scopus 로고    scopus 로고
    • Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus
    • WALCHNER M, MEURER M, PLEWIG G, MESSER G: Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus. Int. J. Dermatol. (2000) 39:383-388.
    • (2000) Int. J. Dermatol. , vol.39 , pp. 383-388
    • Walchner, M.1    Meurer, M.2    Plewig, G.3    Messer, G.4
  • 38
    • 0032895650 scopus 로고    scopus 로고
    • Thalidomide on the comeback trail
    • HALES B: Thalidomide on the comeback trail. Nat. Med. (1999) 5:489-490.
    • (1999) Nat. Med. , vol.5 , pp. 489-490
    • Hales, B.1
  • 39
    • 0036579909 scopus 로고    scopus 로고
    • Effects of putative hydroxylated metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation
    • MARKS MG, SHI J, FRY MO et al.: Effects of putative hydroxylated metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol. Pharm. Bull. (2002) 25:597-604.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 597-604
    • Marks, M.G.1    Shi, J.2    Fry, M.O.3
  • 40
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-α
    • CORRAL LG, HASLETT PAJ, MULLER GW et al.: Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-α. J. Immunol. (1999)163:380-386.
    • (1999) J. Immunol. , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.J.2    Muller, G.W.3
  • 41
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple mieloma
    • RICHARDSON PG, SCHLOSSMAN R, WELLER E et al.: Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple mieloma. Blood (2002) 100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.2    Weller, E.3
  • 42
    • 0037308584 scopus 로고    scopus 로고
    • A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with aletred expression of bcl-2 family proteins
    • MARRIOTT JB, CLARKE IA, CZAJIKA A et al.: A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with aletred expression of bcl-2 family proteins. Cancer Res. (2003) 63:593-599.
    • (2003) Cancer Res. , vol.63 , pp. 593-599
    • Marriott, J.B.1    Clarke, I.A.2    Czajika, A.3
  • 43
    • 0033785490 scopus 로고    scopus 로고
    • A review of angiogenesis and antiangiogenic therapy with thalidomide in multiple myeloma
    • RAJKUMAR SV, WITZIG TE: A review of angiogenesis and antiangiogenic therapy with thalidomide in multiple myeloma. Cancer Treat. Rev. (2000) 26:351-362.
    • (2000) Cancer Treat. Rev. , vol.26 , pp. 351-362
    • Rajkumar, S.V.1    Witzig, T.E.2
  • 44
    • 0030887695 scopus 로고    scopus 로고
    • Standard therapy versus autologous transplantation in multiple myeloma
    • ATTAL M, HAROUSSEAU J-L: Standard therapy versus autologous transplantation in multiple myeloma. Hematol. Oncol. Clin. North Am. (1997) 11:133-146.
    • (1997) Hematol. Oncol. Clin. North Am. , vol.11 , pp. 133-146
    • Attal, M.1    Harousseau, J.-L.2
  • 45
    • 0033928972 scopus 로고    scopus 로고
    • The biology of multiple myeloma
    • DRAK J, KAUFMANN H, URBAUER E et al.: The biology of multiple myeloma. Lancet (2000) 126:441-447.
    • (2000) Lancet , vol.126 , pp. 441-447
    • Drak, J.1    Kaufmann, H.2    Urbauer, E.3
  • 46
    • 0034700846 scopus 로고    scopus 로고
    • New insights into role of microenvironment in multiple myeloma
    • TRICOT G: New insights into role of microenvironment in multiple myeloma. Lancet (2000) 355:248-250.
    • (2000) Lancet , vol.355 , pp. 248-250
    • Tricot, G.1
  • 47
    • 0033083962 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies
    • BELLAMY WT, RICHTER L, FRUTIGER Y et al.: Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res. (1999) 59:728-733.
    • (1999) Cancer Res. , vol.59 , pp. 728-733
    • Bellamy, W.T.1    Richter, L.2    Frutiger, Y.3
  • 48
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • PODAR K, TAI Y-T, DAVIES FE et al.: Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood (2001) 98:428-435.
    • (2001) Blood , vol.98 , pp. 428-435
    • Podar, K.1    Tai, Y.-T.2    Davies, F.E.3
  • 49
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
    • VACCA A, RIBATTI D, PRESTA M et al.: Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood (1999) 93:3064-3073.
    • (1999) Blood , vol.93 , pp. 3064-3073
    • Vacca, A.1    Ribatti, D.2    Presta, M.3
  • 50
    • 0031985198 scopus 로고    scopus 로고
    • Multiple myeloma: Increasing evidence for a multistep transformation process
    • HALLEK M, BERGSAGEL PL, ANDERSON KC: Multiple myeloma: increasing evidence for a multistep transformation process. Blood (1998) 91:3-21.
    • (1998) Blood , vol.91 , pp. 3-21
    • Hallek, M.1    Bergsagel, P.L.2    Anderson, K.C.3
  • 51
    • 0031984216 scopus 로고    scopus 로고
    • BCL-X expression in multiple myeloma: Possible indicator of chemoresistance
    • TU Y, RENNER S, XU F et al.: BCL-X expression in multiple myeloma: possible indicator of chemoresistance. Cancer Res. (1998) 58:256-262.
    • (1998) Cancer Res. , vol.58 , pp. 256-262
    • Tu, Y.1    Renner, S.2    Xu, F.3
  • 52
    • 0036220361 scopus 로고    scopus 로고
    • Non traditional cytotoxic therapies for relapsed/refractory multiple myeloma
    • HUSSEIN MA: Non traditional cytotoxic therapies for relapsed/refractory multiple myeloma. Oncologist (2002) 7:20-29.
    • (2002) Oncologist , vol.7 , pp. 20-29
    • Hussein, M.A.1
  • 53
    • 0037491382 scopus 로고    scopus 로고
    • Marked activity also in del 13 multiple myeloma of PS 341 and subsequent thalidomide in a setting of resistance to post-autotransplant salvage therapies
    • ZANGARI M, BARLOGIE B, PRATHER J et al.: Marked activity also in del 13 multiple myeloma of PS 341 and subsequent thalidomide in a setting of resistance to post-autotransplant salvage therapies. Blood (2002) 100:105a.
    • (2002) Blood , vol.100
    • Zangari, M.1    Barlogie, B.2    Prather, J.3
  • 54
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • SINGHAL S, MEHTA J, DESIKAN R et al.: Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med. (1999) 341:1565-1571.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 55
    • 0029925419 scopus 로고    scopus 로고
    • Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade
    • GEITZ H, HANDT S, ZWINGENBERGER K: Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade. Immunopharmacology (1996) 31:213-221.
    • (1996) Immunopharmacology , vol.31 , pp. 213-221
    • Geitz, H.1    Handt, S.2    Zwingenberger, K.3
  • 56
    • 0026080801 scopus 로고
    • Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
    • SAMPAIO EP, SARNO EN, GALILLY R et al.: Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J. Exp. Med. (1991) 173:699-703.
    • (1991) J. Exp. Med. , vol.173 , pp. 699-703
    • Sampaio, E.P.1    Sarno, E.N.2    Galilly, R.3
  • 57
    • 0033485968 scopus 로고    scopus 로고
    • Thalidomide as an emerging immunotherapeutic agent
    • MARRIOTT JB, MULLER G, DALGLEISH AG: Thalidomide as an emerging immunotherapeutic agent. Immunol. Today (1999) 20:538-540.
    • (1999) Immunol. Today , vol.20 , pp. 538-540
    • Marriott, J.B.1    Muller, G.2    Dalgleish, A.G.3
  • 58
    • 0028928143 scopus 로고
    • The immunosuppressive drug thalidomide induces T helper cell Type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures
    • MCHUGH SM, RIFKIN IR, DEIGHTON J et al.: The immunosuppressive drug thalidomide induces T helper cell Type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin. Exp. Immunol. (1995) 99:160-167.
    • (1995) Clin. Exp. Immunol. , vol.99 , pp. 160-167
    • McHugh, S.M.1    Rifkin, I.R.2    Deighton, J.3
  • 59
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • DAVIES FE, RAJE N, HIDESHIMA T et al.: Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood (2001) 98:210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 60
    • 0033942084 scopus 로고    scopus 로고
    • Phase II evaluation of thalidomide in patients with metastatic breast cancer
    • BAIDAS SM, WINER EP, FLEMING GF et al.: Phase II evaluation of thalidomide in patients with metastatic breast cancer. J. Clin. Oncol. (2000) 18:2710-2717.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2710-2717
    • Baidas, S.M.1    Winer, E.P.2    Fleming, G.F.3
  • 61
    • 0033980850 scopus 로고    scopus 로고
    • Continous low dose thalidomide: A Phase II study in advanced melanoma, renal cell, ovarian and breast cancer
    • EISEN T, BOSHOFF C, MAK I et al.: Continous low dose thalidomide: a Phase II study in advanced melanoma, renal cell, ovarian and breast cancer. Br. J. Cancer (2000) 82:812-817.
    • (2000) Br. J. Cancer , vol.82 , pp. 812-817
    • Eisen, T.1    Boshoff, C.2    Mak, I.3
  • 62
    • 0034574175 scopus 로고    scopus 로고
    • Development of angiogenesis inhibition as therapy for prostate cancer
    • DALIANI D: Development of angiogenesis inhibition as therapy for prostate cancer. Oncology (Huntingt.) (2000) 14:21-23.
    • (2000) Oncology (Huntingt.) , vol.14 , pp. 21-23
    • Daliani, D.1
  • 63
    • 0033178423 scopus 로고    scopus 로고
    • Therapy for Kaposi's sarcoma: Recent advances and experimental approaches
    • YARCHOAN R: Therapy for Kaposi's sarcoma: recent advances and experimental approaches. J. Acquir. Immune Defic. Syndr. (1999) 21(Suppl. 1):S66-S73.
    • (1999) J. Acquir. Immune Defic. Syndr. , vol.21 , Issue.SUPPL. 1
    • Yarchoan, R.1
  • 64
    • 0033815863 scopus 로고    scopus 로고
    • Thalidomide in the treatment of relapsed multiple myeloma
    • RAJKUMAR SV, FONSECA R, DISPENZIERI A et al.: Thalidomide in the treatment of relapsed multiple myeloma. Mayo Clinic Proc. (2000) 75:897-901.
    • (2000) Mayo Clinic Proc. , vol.75 , pp. 897-901
    • Rajkumar, S.V.1    Fonseca, R.2    Dispenzieri, A.3
  • 65
    • 0034885073 scopus 로고    scopus 로고
    • Thalidomide in the management of multiple myeloma
    • BARLOGIE B, ZANGARI M, SPENCER T et al.: Thalidomide in the management of multiple myeloma. Semin. Hematol. (2001) 38:250-259.
    • (2001) Semin. Hematol. , vol.38 , pp. 250-259
    • Barlogie, B.1    Zangari, M.2    Spencer, T.3
  • 66
    • 0032708238 scopus 로고    scopus 로고
    • Thalidomide - A revival story
    • RAJE N, ANDERSON K: Thalidomide - a revival story. N. Engl. J. Med. (1999) 341:1606-1609.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1606-1609
    • Raje, N.1    Anderson, K.2
  • 67
    • 0034116457 scopus 로고    scopus 로고
    • Frequent good partial remission from thalidomide including best response ever in patients with advanced refractory and relapsed myeloma
    • JULIUSSON G, CELSING F, MALM C et al.: Frequent good partial remission from thalidomide including best response ever in patients with advanced refractory and relapsed myeloma. Br. J. Haematol. (2000) 109:89-96.
    • (2000) Br. J. Haematol. , vol.109 , pp. 89-96
    • Juliusson, G.1    Celsing, F.2    Malm, C.3
  • 68
    • 0034014693 scopus 로고    scopus 로고
    • Therapy with thalidomide in refractory multiple myeloma patients - The revival of an old drug
    • KNELLER A, RAANANI P, BEN-BASSAT I et al.: Therapy with thalidomide in refractory multiple myeloma patients - the revival of an old drug. Br. J. Haematol. (2000) 108:391-393.
    • (2000) Br. J. Haematol. , vol.108 , pp. 391-393
    • Kneller, A.1    Raanani, P.2    Ben-Bassat, I.3
  • 69
    • 0035990841 scopus 로고    scopus 로고
    • Consolidation therapy of multiple myeloma with thalidomide-dexamethasone after intensive chemotherapy
    • ALEXANIAN R, WEBER D, GIRALT S, DELASALLE K: Consolidation therapy of multiple myeloma with thalidomide-dexamethasone after intensive chemotherapy. Ann. Oncol. (2002) 13:1116-1119.
    • (2002) Ann. Oncol. , vol.13 , pp. 1116-1119
    • Alexanian, R.1    Weber, D.2    Giralt, S.3    Delasalle, K.4
  • 70
    • 0034899464 scopus 로고    scopus 로고
    • Thalidomide and dexamethasone combination for refractory multiple myeloma
    • DIMOPOULOS MA, ZERVAS K, KOUVATSEAS G et al.: Thalidomide and dexamethasone combination for refractory multiple myeloma. Annals Onc. (2001) 12:991-995.
    • (2001) Annals Onc. , vol.12 , pp. 991-995
    • Dimopoulos, M.A.1    Zervas, K.2    Kouvatseas, G.3
  • 71
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • WEBER D, RANKIN K, GAVINO M et al.: Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J. Clin. Oncol. (2003) 21:16-19.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3
  • 72
    • 0035895104 scopus 로고    scopus 로고
    • Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
    • MOEHLER TM, NEBEN K, BENNER A et al.: Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy. Blood (2001) 98:3846-3848.
    • (2001) Blood , vol.98 , pp. 3846-3848
    • Moehler, T.M.1    Neben, K.2    Benner, A.3
  • 73
    • 0035469858 scopus 로고    scopus 로고
    • Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy
    • ZANGARI M, ANAISSIE E, BARLOGIE B et al.: Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy. Blood (2001) 98:1614-1615.
    • (2001) Blood , vol.98 , pp. 1614-1615
    • Zangari, M.1    Anaissie, E.2    Barlogie, B.3
  • 74
    • 85047682765 scopus 로고    scopus 로고
    • The combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex) is feasible and can be an option for relapsed/refractory multiple myeloma
    • GARCIA-SANZ I, GONZALEZ-FRAILE MI, SIERRA M, LOPEZ C, GONZALEZ M, SAN MIGUEL JF: The combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex) is feasible and can be an option for relapsed/refractory multiple myeloma. Hematol. J. (2002) 3:43-48.
    • (2002) Hematol. J. , vol.3 , pp. 43-48
    • Garcia-Sanz, I.1    Gonzalez-Fraile, M.I.2    Sierra, M.3    Lopez, C.4    Gonzalez, M.5    San Miguel, J.F.6
  • 75
    • 0003298401 scopus 로고    scopus 로고
    • A Phase I study of oral CC5013, an immunomodulatory thalidomide derivative in patients with relapsed and refractory multiple myeloma
    • (Abstract)
    • RICHARDSON PG, SCHLOSSMAN RL, HIDESHIMA T: A Phase I study of oral CC5013, an immunomodulatory thalidomide derivative in patients with relapsed and refractory multiple myeloma. Blood (2001) 98:775 (Abstract).
    • (2001) Blood , vol.98 , pp. 775
    • Richardson, P.G.1    Schlossman, R.L.2    Hideshima, T.3
  • 76
    • 0037359277 scopus 로고    scopus 로고
    • Tolerability and efficacy of thalidomide for the teratment of patients with light chain-associated (AL) amyloidosis
    • SELDIN DC, CHOUFANI EB, DEMBER LM et al.: Tolerability and efficacy of thalidomide for the teratment of patients with light chain-associated (AL) amyloidosis. Clin. Lymphoma (2003) 3:241-246.
    • (2003) Clin. Lymphoma , vol.3 , pp. 241-246
    • Seldin, D.C.1    Choufani, E.B.2    Dember, L.M.3
  • 77
    • 0035881040 scopus 로고    scopus 로고
    • Treatment of Waldenstrom's macroglobulinemia with thalidomide
    • DIMOPOULOS MA, ZOMAS A, VINIOU NA et al.: Treatment of Waldenstrom's macroglobulinemia with thalidomide. J. Clin. Oncol. (2001) 19:3596-3601.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3596-3601
    • Dimopoulos, M.A.1    Zomas, A.2    Viniou, N.A.3
  • 78
    • 0034999927 scopus 로고    scopus 로고
    • CD-20-directed antibody-mediated immunotherapy induces responses and facilitates hematologic recovery in patients with Waldenstrom's macroglobulinemia
    • TREON SP, AGUS TB, LINK B et al.: CD-20-directed antibody-mediated immunotherapy induces responses and facilitates hematologic recovery in patients with Waldenstrom's macroglobulinemia. J. Immunother. (2001) 24:272-279.
    • (2001) J. Immunother. , vol.24 , pp. 272-279
    • Treon, S.P.1    Agus, T.B.2    Link, B.3
  • 79
    • 0036022680 scopus 로고    scopus 로고
    • Waldenstrom's macroglobulinaemia: Current therapy and future approaches
    • DESIKAN R, LI Z, JAGANNATH S: Waldenstrom's macroglobulinaemia: current therapy and future approaches. BioDrugs (2002) 6:201-207.
    • (2002) BioDrugs , vol.6 , pp. 201-207
    • Desikan, R.1    Li, Z.2    Jagannath, S.3
  • 80
    • 0037396216 scopus 로고    scopus 로고
    • Treatment of Waldenstrom's macroglobulinemia with clarithromycin, low-dose thalidomide, and dexamethasone
    • COLEMAN M, LEONARD J, LYONS L et al.: Treatment of Waldenstrom's macroglobulinemia with clarithromycin, low-dose thalidomide, and dexamethasone. Semin. Oncol. (2003) 30:270-274.
    • (2003) Semin. Oncol. , vol.30 , pp. 270-274
    • Coleman, M.1    Leonard, J.2    Lyons, L.3
  • 81
    • 0029995264 scopus 로고    scopus 로고
    • Angiogenesis spectrum in the stroma of B-cell non-Hodgkin's lymphomas. An immunohistochemical and ultrastructural study
    • RIBATTI D, VACCA A, NICO B, FANELLI M, RONCALI L, DAMMACCO F: Angiogenesis spectrum in the stroma of B-cell non-Hodgkin's lymphomas. An immunohistochemical and ultrastructural study. Eur. J. Haematol. (1996) 56:45-53.
    • (1996) Eur. J. Haematol. , vol.56 , pp. 45-53
    • Ribatti, D.1    Vacca, A.2    Nico, B.3    Fanelli, M.4    Roncali, L.5    Dammacco, F.6
  • 82
    • 0034650418 scopus 로고    scopus 로고
    • Angiogenesis extent and density of mast cells with tryptase activity increase simultaneously with pathological progression in B-cell non Hodgkin's lymphomas
    • RIBATTI D, VACCA A, MARZULLO A, RIA R, RONCALI L, DAMMACCO F: Angiogenesis extent and density of mast cells with tryptase activity increase simultaneously with pathological progression in B-cell non Hodgkin's lymphomas. Int. J. Cancer (2000) 85:171-175.
    • (2000) Int. J. Cancer , vol.85 , pp. 171-175
    • Ribatti, D.1    Vacca, A.2    Marzullo, A.3    Ria, R.4    Roncali, L.5    Dammacco, F.6
  • 83
    • 0033002831 scopus 로고    scopus 로고
    • Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
    • VACCA A, RIBATTI D, RUCO L et al.: Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas. Br. J. Cancer (1999) 79:965-970.
    • (1999) Br. J. Cancer , vol.79 , pp. 965-970
    • Vacca, A.1    Ribatti, D.2    Ruco, L.3
  • 84
  • 85
    • 0034655595 scopus 로고    scopus 로고
    • Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
    • PADRO' T, RUIZ S, BIEKER R et al.: Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood (2000) 95:2637-2644.
    • (2000) Blood , vol.95 , pp. 2637-2644
    • Padro', T.1    Ruiz, S.2    Bieker, R.3
  • 86
    • 0036464605 scopus 로고    scopus 로고
    • Efficacy and safety of thalidomide in patients with acute myeloid leukemia
    • STEINS MB, PADRO T, BIEJER R et al.: Efficacy and safety of thalidomide in patients with acute myeloid leukemia. Blood (2002) 99:834-839.
    • (2002) Blood , vol.99 , pp. 834-839
    • Steins, M.B.1    Padro, T.2    Biejer, R.3
  • 88
    • 0035883101 scopus 로고    scopus 로고
    • Thalidomide produces transfusion independence in long-standing refractory anemias of patients with myelodysplastic syndromes
    • RAZA A, MEYERP, DUTT D et al.: Thalidomide produces transfusion independence in long-standing refractory anemias of patients with myelodysplastic syndromes. Blood (2001) 98:958-65.
    • (2001) Blood , vol.98 , pp. 958-965
    • Raza, A.1    Meyerp, A.2    Dutt, D.3
  • 90
    • 0034254254 scopus 로고    scopus 로고
    • Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes
    • RAZA A: Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes. Microsc. Res. Tech. (2000) 50:229-235.
    • (2000) Microsc. Res. Tech. , vol.50 , pp. 229-235
    • Raza, A.1
  • 91
    • 0028075307 scopus 로고
    • The basis for current treatment recommendations for malignant gliomas
    • FINE HA: The basis for current treatment recommendations for malignant gliomas. J. Neurooncol. (1994) 20:111-121.
    • (1994) J. Neurooncol. , vol.20 , pp. 111-121
    • Fine, H.A.1
  • 92
    • 0026608650 scopus 로고
    • Correlations of bFGF expression levels with degree of malignancy and vascularity in human gliomas
    • TAKAHASHI J, FUKUMOTO M, IGORSHI K et al.: Correlations of bFGF expression levels with degree of malignancy and vascularity in human gliomas. J. Neurosurg. (1992) 76:792-798.
    • (1992) J. Neurosurg. , vol.76 , pp. 792-798
    • Takahashi, J.1    Fukumoto, M.2    Igorshi, K.3
  • 93
    • 0025201337 scopus 로고
    • Immunohistochemical localization of bFGF in astrocytomas
    • ZAGZAG D, MILLER D, SATO Y et al.: Immunohistochemical localization of bFGF in astrocytomas. Cancer Res. (1990) 50:7393-7398.
    • (1990) Cancer Res. , vol.50 , pp. 7393-7398
    • Zagzag, D.1    Miller, D.2    Sato, Y.3
  • 94
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • PLATE KH, BREIER G, WEICH HA et al.: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature (1992) 359:845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3
  • 95
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia-initiated angiogenesis
    • SHWEIKI D, ITIN A, SOFFER D et al.: Vascular endothelial growth factor induced by hypoxia-initiated angiogenesis. Nature (1992) 352:843-845.
    • (1992) Nature , vol.352 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3
  • 96
    • 0015291143 scopus 로고
    • Tumour angiogenesis: A quantitative method for histologic grading
    • BREM S, COTRAN R, FOLKMAN J: Tumour angiogenesis: A quantitative method for histologic grading. J. Natl. Cancer Inst. (1972) 48:347-356.
    • (1972) J. Natl. Cancer Inst. , vol.48 , pp. 347-356
    • Brem, S.1    Cotran, R.2    Folkman, J.3
  • 97
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • MILLAUER B, SHAWVER LK, PLATE KH et al.: Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (1994) 367:576-579.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3
  • 98
    • 0025282206 scopus 로고
    • Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance
    • MAXWELL M, NABER SP, WOLFE HJ et al.: Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. J. Clin. Invest. (1990) 86:131-140.
    • (1990) J. Clin. Invest. , vol.86 , pp. 131-140
    • Maxwell, M.1    Naber, S.P.2    Wolfe, H.J.3
  • 99
    • 0029754648 scopus 로고    scopus 로고
    • Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin
    • HSU SC, VOLPERT OV, STECK PA et al.: Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin. Cancer Res. (1996) 56:5684-5691.
    • (1996) Cancer Res. , vol.56 , pp. 5684-5691
    • Hsu, S.C.1    Volpert, O.V.2    Steck, P.A.3
  • 100
    • 0035051092 scopus 로고    scopus 로고
    • Thalidomide as an anti-angiogenic agent in relapsed gliomas
    • SHORT SC, TRAISH D, DOWE A et al.: Thalidomide as an anti-angiogenic agent in relapsed gliomas. J. Neuroonc. (2001) 51:41-45.
    • (2001) J. Neuroonc. , vol.51 , pp. 41-45
    • Short, S.C.1    Traish, D.2    Dowe, A.3
  • 101
    • 0035191268 scopus 로고    scopus 로고
    • Phase II study of thalidomide in the treatment of recurrent glioblastoma multiforme
    • MARX GM, PAVLAKIS N, MCCOWATT S et al.: Phase II study of thalidomide in the treatment of recurrent glioblastoma multiforme. J. Neuroonc. (2001) 54:31-38.
    • (2001) J. Neuroonc. , vol.54 , pp. 31-38
    • Marx, G.M.1    Pavlakis, N.2    McCowatt, S.3
  • 103
    • 0009115041 scopus 로고    scopus 로고
    • NCCN practice guidelines for melanoma: The complete library of NCCN guidelines (CD-ROM)
    • Version 2000. National Comprehensive Cancer Network, Rockledge, PA, USA
    • HOUGHTON AN, BLOOMER WD, CHU D et al.: NCCN practice guidelines for melanoma: the complete library of NCCN guidelines (CD-ROM). Version 2000. National Comprehensive Cancer Network, Rockledge, PA, USA (2000).
    • (2000)
    • Houghton, A.N.1    Bloomer, W.D.2    Chu, D.3
  • 104
    • 0032976897 scopus 로고    scopus 로고
    • Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon α-2b
    • ROSENBERG SA, YANG JC, SCHWARTZENTRUBER DJ et al.: Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon α-2b. J. Clin. Oncol. (1999) 17:968-975.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 968-975
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3
  • 105
    • 0344791670 scopus 로고    scopus 로고
    • Randomized trial of treatment with cisplatin, and interleukin-2 either alone or in combination with interferon α-2a in patients with metastatic melanoma
    • DORRAL T, NEIGRIER S, CHEVREAN C et al.: Randomized trial of treatment with cisplatin, and interleukin-2 either alone or in combination with interferon α-2a in patients with metastatic melanoma. Cancer (1999) 85:1060-1066.
    • (1999) Cancer , vol.85 , pp. 1060-1066
    • Dorral, T.1    Neigrier, S.2    Chevrean, C.3
  • 106
    • 0033989205 scopus 로고    scopus 로고
    • Randomized Phase III study of temozolamide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma
    • MIDDLETON MR, GROB JJ, AARONSON N et al.: Randomized Phase III study of temozolamide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J. Clin. Oncol. (2000) 18:158-166.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 158-166
    • Middleton, M.R.1    Grob, J.J.2    Aaronson, N.3
  • 107
    • 0000827287 scopus 로고    scopus 로고
    • Three-arm Phase II study of temozolamide (TMZ) in metastatic melanoma (MM): Preliminary results
    • (Abstract 2257)
    • ARANCE A, MIDDLETON M, LORIGAN PC et al.: Three-arm Phase II study of temozolamide (TMZ) in metastatic melanoma (MM): preliminary results. Proc. Am. Soc. Clin. Oncol. (2000) 19:573a (Abstract 2257).
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Arance, A.1    Middleton, M.2    Lorigan, P.C.3
  • 108
    • 0009117193 scopus 로고    scopus 로고
    • Phase II study of outpatient biochemotherapy with temozolamide, for metastatic melanoma: BRUOG MEL 69
    • (Abstract 2900)
    • AHMED M, READY N, ARONSON F et al.: Phase II study of outpatient biochemotherapy with temozolamide, for metastatic melanoma: BRUOG MEL 69. Proc. Am. Soc. Clin. Oncol. (2001) 20:287b (Abstract 2900).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Ahmed, M.1    Ready, N.2    Aronson, F.3
  • 109
    • 0003217919 scopus 로고    scopus 로고
    • Phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, temozolamide (CVT), interleukin-2 (IL-2) and interferon α-2b (IFN) in patients with metastatic melanoma
    • (Abstract 1391)
    • ATKINS MB, GOLLOB JA, MIER JW et al.: Phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, temozolamide (CVT), interleukin-2 (IL-2) and interferon α-2b (IFN) in patients with metastatic melanoma. Proc. Am. Soc. Clin. Oncol. (2001) 20:349a (Abstract 1391).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Atkins, M.B.1    Gollob, J.A.2    Mier, J.W.3
  • 110
    • 0028944359 scopus 로고
    • Cancer Research campaign Phase II trial of temozolamide in metastatic melanoma
    • BLEECHEN NM, NEWLANDS ES, LEE SM et al.: Cancer Research campaign Phase II trial of temozolamide in metastatic melanoma. J. Clin. Oncol. (1995) 13:910-913.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 910-913
    • Bleechen, N.M.1    Newlands, E.S.2    Lee, S.M.3
  • 111
    • 0032188739 scopus 로고    scopus 로고
    • Phase I trial of temozolamide using an extended continuous oral schedule
    • BROCK CS, NEWLANDS ES, WEDGE SR et al.: Phase I trial of temozolamide using an extended continuous oral schedule. Cancer Res. (1998) 58:4363-4367.
    • (1998) Cancer Res. , vol.58 , pp. 4363-4367
    • Brock, C.S.1    Newlands, E.S.2    Wedge, S.R.3
  • 112
    • 0036605798 scopus 로고    scopus 로고
    • Temozolamide plus thalidomide in patients with advanced melanoma: Results of a dose-finding trial
    • HWU WJ, KROWN SE, PANAGEAS KS et al.: Temozolamide plus thalidomide in patients with advanced melanoma: results of a dose-finding trial. J. Clin. Oncol. (2002) 20:2610-2615.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2610-2615
    • Hwu, W.J.1    Krown, S.E.2    Panageas, K.S.3
  • 113
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid, and other disease
    • FOLKMAN J: Angiogenesis in cancer, vascular, rheumatoid, and other disease. Nat. Med. (1995) 1:27-31.
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 114
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other antiangiogenic agents
    • TEICHER BA, HOLDEN SA, GULSHAN A et al.: Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other antiangiogenic agents. Int. J. Cancer (1994) 57:920-925.
    • (1994) Int. J. Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Gulshan, A.3
  • 116
    • 0027482301 scopus 로고
    • Expression of basic fibroblast growth factor in primary human renal tumors: Correlation with poor survival
    • NANUS DM, SCHMITZ-DRAGER BJ, MOTZER RJ: Expression of basic fibroblast growth factor in primary human renal tumors: correlation with poor survival. J. Natl. Cancer Inst. (1993) 85:1597-1579.
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 1579-1597
    • Nanus, D.M.1    Schmitz-Drager, B.J.2    Motzer, R.J.3
  • 117
    • 0036175516 scopus 로고    scopus 로고
    • The biological treatment of renal cell carcinoma and melanoma
    • NATHAN PD, EISEN G: The biological treatment of renal cell carcinoma and melanoma. Lancet Oncol. (2002) 3:89-96.
    • (2002) Lancet Oncol. , vol.3 , pp. 89-96
    • Nathan, P.D.1    Eisen, G.2
  • 118
    • 0028174924 scopus 로고
    • Over coming TNF-α and drug resistance of human renal cell carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha prodrugs: The role of TNF-α downregulation in tumor cell sensitisation
    • MIZUTANI Y, CHAUHAN D, SHIMA Y et al.: Over coming TNF-α and drug resistance of human renal cell carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha prodrugs: the role of TNF-α downregulation in tumor cell sensitisation. J. Urol. (1994) 151:1697-1702.
    • (1994) J. Urol. , vol.151 , pp. 1697-1702
    • Mizutani, Y.1    Chauhan, D.2    Shima, Y.3
  • 119
    • 0035990828 scopus 로고    scopus 로고
    • Phase II trial of thalidomide in renal cell carcinoma
    • ESCUDIER B, LASSAU N, COUANET D et al.: Phase II trial of thalidomide in renal cell carcinoma. Ann. Oncol. (2002) 13(7):1029-1035.
    • (2002) Ann. Oncol. , vol.13 , Issue.7 , pp. 1029-1035
    • Escudier, B.1    Lassau, N.2    Couanet, D.3
  • 120
    • 0037108279 scopus 로고    scopus 로고
    • A high rate of venous thromboembolism in a multi-institutional Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma
    • DESAI AA, VOGELZANG NJ, RINI BI et al.: A high rate of venous thromboembolism in a multi-institutional Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma. Cancer (2002) 95(8):1629-1636.
    • (2002) Cancer , vol.95 , Issue.8 , pp. 1629-1636
    • Desai, A.A.1    Vogelzang, N.J.2    Rini, B.I.3
  • 121
    • 17944362585 scopus 로고    scopus 로고
    • The treatment of advanced renal cell cancer with high-dose oral thalidomide
    • STEBBING J, BENSON C, EISEN Y et al.: The treatment of advanced renal cell cancer with high-dose oral thalidomide. Br. J. Cancer (2001) 85(7):953-958.
    • (2001) Br. J. Cancer , vol.85 , Issue.7 , pp. 953-958
    • Stebbing, J.1    Benson, C.2    Eisen, Y.3
  • 122
    • 0036139999 scopus 로고    scopus 로고
    • Phase II trial of Thalidomide for patients with advanced renal cell carcinoma
    • MOTZER RJ, BERG W, GINSBERG et al.: Phase II trial of Thalidomide for patients with advanced renal cell carcinoma. J. Clin. Oncol. (2002) 20(1):302-306.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.1 , pp. 302-306
    • Motzer, R.J.1    Berg, W.2    Ginsberg, A.3
  • 123
    • 0037103101 scopus 로고    scopus 로고
    • A pilot study of thalidomide in patients with progressive metastatic renal cell carcinoma
    • DALIANI DD, PAPANDREOU CN, THALL PF et al.: A pilot study of thalidomide in patients with progressive metastatic renal cell carcinoma. Cancer (2002) 95(4):758-765.
    • (2002) Cancer , vol.95 , Issue.4 , pp. 758-765
    • Daliani, D.D.1    Papandreou, C.N.2    Thall, P.F.3
  • 124
    • 0036828582 scopus 로고    scopus 로고
    • A Phase II study of thalidomide in advanced metastatic renal cell carcinoma
    • MINOR DR, MONROE D, DAMICO LA et al.: A Phase II study of thalidomide in advanced metastatic renal cell carcinoma. Invest. New Drugs (2002) 20(4):389-393.
    • (2002) Invest. New Drugs , vol.20 , Issue.4 , pp. 389-393
    • Minor, D.R.1    Monroe, D.2    Damico, L.A.3
  • 125
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • MOTZER RJ, MAZUMDAR M, BACIK J et al.: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J. Clin. Oncol. (1999) 17:2530-2540.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 127
    • 0037050355 scopus 로고    scopus 로고
    • Lung cancer - Time to move on from chemotherapy
    • CARNEY DN: Lung cancer - time to move on from chemotherapy. N. Engl. J. Med. (2002) 346:126-128.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 126-128
    • Carney, D.N.1
  • 128
    • 0036892178 scopus 로고    scopus 로고
    • The role of new agents in the treatment of non-small cell lung cancer
    • BROKER LE, GIACCONE G: The role of new agents in the treatment of non-small cell lung cancer. Eur. J. Cancer (2002) 38:23476-23461.
    • (2002) Eur. J. Cancer , vol.38 , pp. 23461-23476
    • Broker, L.E.1    Giaccone, G.2
  • 129
    • 0003202346 scopus 로고    scopus 로고
    • Pilot and safety trial of carboplatin, paclitaxel and thalidomide in advanced non small cell lung cancer
    • (Abstract No. 2130)
    • MERCHANT JJ, HAMMES LC, LARSON ML et al.: Pilot and safety trial of carboplatin, paclitaxel and thalidomide in advanced non small cell lung cancer. Proc. Am. Soc. Clin. Oncol. (2002) 19(Abstract No. 2130).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Merchant, J.J.1    Hammes, L.C.2    Larson, M.L.3
  • 130
    • 0037828909 scopus 로고
    • Thalidomide inhibits superantigen-induced TNFα release in mice
    • 12th European Immunology Meeting of the European Federation of Immunologic Societies, Barcelona, Spain
    • SCHNEIDER J, WNENDT S, KORIOTH J et al.: Thalidomide inhibits superantigen-induced TNFα release in mice. 12th European Immunology Meeting of the European Federation of Immunologic Societies, Barcelona, Spain (1994).
    • (1994)
    • Schneider, J.1    Wnendt, S.2    Korioth, J.3
  • 131
    • 0033996043 scopus 로고    scopus 로고
    • New chemotherapeutic agents for small cell lung cancer
    • KELLY K: New chemotherapeutic agents for small cell lung cancer. Chest (2000) 117(Suppl. 4):156S-162S.
    • (2000) Chest , vol.117 , Issue.SUPPL. 4
    • Kelly, K.1
  • 132
    • 0036955453 scopus 로고    scopus 로고
    • Long-term survival of a patient with small-cell lung cancer (SCLC) following treatment with thalidomide and combination chemotherapy
    • MALL JW, PHILIPP AW, MALL W et al.: Long-term survival of a patient with small-cell lung cancer (SCLC) following treatment with thalidomide and combination chemotherapy. Angiogenesis (2002) 5:11-13.
    • (2002) Angiogenesis , vol.5 , pp. 11-13
    • Mall, J.W.1    Philipp, A.W.2    Mall, W.3
  • 133
    • 0031675320 scopus 로고    scopus 로고
    • Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre
    • FIFE K, HOWARD MR, GRACIE F et al.: Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre. Int. J. STD AIDS (1998) 9:751-755.
    • (1998) Int. J. STD AIDS , vol.9 , pp. 751-755
    • Fife, K.1    Howard, M.R.2    Gracie, F.3
  • 134
    • 0033916672 scopus 로고    scopus 로고
    • Activity of thalidomide in AIDS-related Kaposi's sarcoma
    • LITTLE RF, WYVILL KM, PLUDA JM et al.: Activity of thalidomide in AIDS-related Kaposi's sarcoma. J. Clin. Oncol. (2000) 18:2593-602.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2593-2602
    • Little, R.F.1    Wyvill, K.M.2    Pluda, J.M.3
  • 135
    • 0034641526 scopus 로고    scopus 로고
    • Effect of thalidomide on gastrointestinal toxic effects of irinotecan
    • GOVINDARAJAN R, HEATON KM, BROADWATER R et al.: Effect of thalidomide on gastrointestinal toxic effects of irinotecan. Lancet (2000) 356:566-567.
    • (2000) Lancet , vol.356 , pp. 566-567
    • Govindarajan, R.1    Heaton, K.M.2    Broadwater, R.3
  • 136
    • 0034783270 scopus 로고    scopus 로고
    • A randomised Phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer
    • FIGG WD, DAHUT W, DURAY P et al.: A randomised Phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer. Clin. Cancer Res. (2001) 7:1888-1893.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1888-1893
    • Figg, W.D.1    Dahut, W.2    Duray, P.3
  • 138
    • 0003345277 scopus 로고    scopus 로고
    • Thalidomide induced cessation of weight loss and improved advanced cancer patients with cachexia
    • (Abstract 2396)
    • BOASBERG PD, O'DAY SJ, WEISBERG M et al.: Thalidomide induced cessation of weight loss and improved advanced cancer patients with cachexia. Proc. Am. Soc. Clin. Oncol. (2000) (Abstract 2396).
    • (2000) Proc. Am. Soc. Clin. Oncol.
    • Boasberg, P.D.1    O'Day, S.J.2    Weisberg, M.3
  • 139
    • 0032922147 scopus 로고    scopus 로고
    • S.T.E.P.S.: A comprehensive program for controlling and monitoring access to thalidomide
    • ZELDIS JB, WILLIAMS BA, THOMAS SD, ELSAYED ME: S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide. Clin. Ther. (1999) 21:310-330.
    • (1999) Clin. Ther. , vol.21 , pp. 310-330
    • Zeldis, J.B.1    Williams, B.A.2    Thomas, S.D.3    Elsayed, M.E.4
  • 140
    • 0028879821 scopus 로고
    • Thalidomide-induced neuropathy and genetic differences in drug metabolism
    • HARLAND CC, STEVENTON GB, MARSDEN JR: Thalidomide-induced neuropathy and genetic differences in drug metabolism. Eur. J. Clin. Pharmacol. (1995) 49:1-16.
    • (1995) Eur. J. Clin. Pharmacol. , vol.49 , pp. 1-16
    • Harland, C.C.1    Steventon, G.B.2    Marsden, J.R.3
  • 141
    • 0034727058 scopus 로고    scopus 로고
    • Life-threatening toxic epidermal necrolysis with thalidomide therapy for myeloma
    • RAJKUMAR SV, GERTZ MA, WITZIG TE: Life-threatening toxic epidermal necrolysis with thalidomide therapy for myeloma. N. Engl. J. Med. (2000) 343:972-973.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 972-973
    • Rajkumar, S.V.1    Gertz, M.A.2    Witzig, T.E.3
  • 143
    • 0035927983 scopus 로고    scopus 로고
    • Deep venous thrombosis and thalidomide therapy for multiple myeloma
    • OSMAN K, COMENZO R, RAJKUMAR SV: Deep venous thrombosis and thalidomide therapy for multiple myeloma. N. Engl. J. Med. (2001) 344:1951-1952.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1951-1952
    • Osman, K.1    Comenzo, R.2    Rajkumar, S.V.3
  • 144
    • 79960970619 scopus 로고    scopus 로고
    • Risk factors for deep vein thrombosis (DVT) in a large group of myeloma patients (Pts) treated with thalidomide (Thal)
    • (Abstract 681)
    • ZANGARI M, SIEGEL E, ANASSIE E et al.: risk factors for deep vein thrombosis (DVT) in a large group of myeloma patients (Pts) treated with thalidomide (Thal). Blood (2001) 98 (Abstract 681).
    • (2001) Blood , vol.98
    • Zangari, M.1    Siegel, E.2    Anassie, E.3
  • 145
    • 0034321993 scopus 로고    scopus 로고
    • Research on thalidomide in solid tumors, hematologic malignancies, and supportive care
    • HUSSEIN MA: Research on thalidomide in solid tumors, hematologic malignancies, and supportive care. Oncology (2000) 14:9-15.
    • (2000) Oncology , vol.14 , pp. 9-15
    • Hussein, M.A.1


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