The metabolic and immunologic effects of short-term thalidomide reatment of patients infected with the human immunodeficiency virus

AIDS Research and Human Retroviruses

Volumn 13, Issue 12, 1997, Pages 1047-1054

  Haslett, Patrick ^a   Hempstead, Margaret ^a   Seidman, Cynthia ^a   Diakun, Jolanta ^a   Vasquez, Dacia ^a   Freedman, Victoria H ^a   Kaplan, Gilla ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; NITROGEN; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BIOSYNTHESIS; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; CALORIC INTAKE; CALORIMETRY; CLINICAL ARTICLE; ENERGY EXPENDITURE; EXTRACELLULAR FLUID; FLUID RETENTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE COUNT; MALE; NITROGEN BALANCE; NITROGEN URINE LEVEL; PRIORITY JOURNAL; T LYMPHOCYTE; WEIGHT GAIN;

EID: 0030746472     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1997.13.1047     Document Type: Article

References (25)

1. Hoover DR, Saah AJ, Bacellar H, Phair J, Detels R, Anderson R, and Kaslow RA: Clinical manifestations of AIDS in the era of Pneumocystis prophylaxis. N Engl J Med 1993;329:1922-1926.
2. Kotler DP, Wang J, and Pierson RN: Body composition studies in patients with the acquired immunodeficiency syndrome. Am J Clin Nut 1985;42:1255-1265.
3. Grunfeld C and Feingold KR: Metabolic disturbances and wasting in the acquired immunodeficiency syndrome. N Eng J Med 1992; 327:329-337.
4. Ehrenpreis ED, Ganger DR, Kochvar DT, Patterson BK, and Craig RM: D-Xylose malabsorption: Characteristic finding in patients with the AIDS wasting syndrome and chronic diarrhea. J Acquir Immune Defic Syndr 1992;5:1047-1050.
5. Hommes MJT, Romini JA, Endert E, and Sauerwein HP: Resting energy expenditure in human immunodeficiency virus-infected asymptomatic men: HIV affects host metabolism in early asymptomatic stage. Am J Clin Nutr 1991;54:311-315.
6. Hellerstein MK, Grunfeld C, Wu K, Christiansen M, Kaempfer S, Kletke C, and Shackleton CHL: Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. J Clin Endocrinol Metab 1993;76:559-565.
7. Lahdevirta J, Maury CPJ, Teppo A-M, and Repo H: Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 1988;85:289-291.
8. Ambrus JL, Poiesz BJ, Lillie MA, Stadler I, Di Bernadino LA, and Chadra KC: Interferon and interferon inhibitor levels in patients infected with varicella-zoster virus, acquired immunodeficiency syndrome-related complex, or Kaposi's sarcoma, and in normal individuals. Am J Med 1989;87:405-407.
9. Zangerle R, Reibnegger G, Wachter H, and Fuchs D: Weight loss in HIV-1 infection is associated with immune activation. AIDS 1993;7:175-181.
10. Belec L, Meillet D, Hernvann A, Gresenguet G, and Gherardi R: Differential elevation of circulating interleukin-1 beta, tumor necrosis factor alpha and interleukin-6 in AIDS-associated cachectic states. Clin Diag Lab Immunol 1994;1:117-120.
11. Sampaio EP, Sarno EN, Gallily R, Cohn ZA, and Kaplan G: Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 1991;173:699-703.
12. Sampaio EP, Kaplan G, Miranda A, Nery JAC, Miguel CP, Viana SM, and Sarno EN: The influence of thalidomide on the clinical and immunological manifestation of erythema nodosum leprosum. J Infect Dis 1993;168:408-414.
13. Tramontana JM, Utaipat U, Molloy A, Akarasewi P, Burroughs M, Makonkawkeyoon S, Johnson B Klausner JD, Rom W, and Kaplan G: Thalidomide treatment reducestumor recrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis. Mol Med 1995;1:384-397.
14. Klausner JD, Makonkawkeyoon S, Akarasewi P, Nakata K, Kasinrerk W, Corral L, Dewar RL, Lane HC, Freedman VH, and Kaplan G: The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 and M. tuberculosis infection. J Acquir Immune Defic Syndr 1996;11:247-257.
15. Rouzer CA and Cerami A: Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removal. Mol and Biochem Parasitol 1980;2:31-38.
16. Alexander IRW: Acute myxedema. Br Med J 1961;II:1434.
17. Kotler DP, Burastero S, Wang J, and Pierson RN: Prediction of body cell mass, fat free mass, and total body water with bioelectrical impedance analysis: Effects of race, sex, and disease. Am J Clin Nutr 1996;64(Suppl.):489S-497S.
18. Forbes GB: Body composition: Influence of nutrition, disease, growth and aging. In: Modern Nutrition in Health and Disease (Shils ME and Young VR, eds.), 7th Ed. Lea & Febiger, Philadelphia, pp. 533-556.
19. Mulligan K, Grunfeld C, Hellerstein M, Neese RA, and Schambelan M: Anabolic effects of recombinant human growth hormone in patients with wasting associated with human immunodeficiency virus infection. J Clin Endocrinol Metab 1993;77:956-962.
20. Dezube BJ, Pardee AB, Chapman B, Beckett L, Korvick JA, Novick WJ, Chiurco J, Kasdan P, Ahlers CM, Ecto LT, Crumpacker CS, and the NIAID AIDS Clinical Trials Group: Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS. J Acquir Immune Defic Syndr 1993;6:787-794.
21. Gad SM, Shannon EJ, Krotoski WA, and Hastings RC: Thalidomide induces imbalances in T-lymphocyte sub-populations in the circulating blood of healthy males. Leprosy Rev 1985;56:35-59.
22. Shannon EJ, Ejigu M, Haile-Mariam HS, Tebebe YB, and Tasesse G: Thalidomide's effectiveness in eythema nodosura leprosum is associated with a decrease in CD4+ cells in the peripheral blood. Leprosy Rev 1992;63:5-11.
23. Shannon EJ and Sandoval F: Thalidomide increases the synthesis of IL-2 in cultures of human mononuclear cells stimulated with concanavalin A, staphylococcal enterotoxin A, and purified protein derivative. Immunopharmacology 1995;31:109-116.
24. Williams I, Weller IVD, Malin A, Anderson J, and Waters MFR: Thalidomide hypersensitivit in AIDS. Lancet 1991;337:436-437.
25. Haslett P, Tramontana J, Burroughs M, Hempstead M, and Kaplan G: Adverse reactions to thalidomide in patients infected with human immunodeficiency virus. Clin Infect Dis 1997;24:in press.