Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells

Journal of Cell Science

Volumn 116, Issue 10, 2003, Pages 2051-2065

  Wang, Yanru ^a   Jerdeva, Galina ^a   Yarber, Francie A ^a   da Costa, Silvia R ^a   Xie, Jiansong ^a   Qian, Limin ^a   Rose, Chadron M ^a   Mazurek, Constance ^a   Kasahara, Noriyuki ^a   Mircheff, Austin K ^a   Hamm Alvarez, Sarah F ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Acinar secretion; Dynein; Exocytosis; Microtubule; rab3D; VAMP2

Indexed keywords

ADENOVIRUS VECTOR; CARBACHOL; CYTOPLASM PROTEIN; DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; NOCODAZOLE; PROTEIN P50; RAB PROTEIN; SORBITOL; SYNAPTOBREVIN; TEAR PROTEIN;

ACINAR CELL; ANIMAL CELL; APICAL MEMBRANE; AQUEOUS HUMOR; ARTICLE; CELL MEMBRANE; CELL TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENSITY GRADIENT; EPITHELIUM CELL; FEMALE; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; LACRIMAL GLAND; MICROTUBULE ASSEMBLY; NONHUMAN; PHASE PARTITIONING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN TRANSPORT; RABBIT;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; CARBACHOL; CELL MEMBRANE; CYTOPLASM; DETERGENTS; DYNEIN ATPASE; EPITHELIAL CELLS; EXOCYTOSIS; FEMALE; LACRIMAL APPARATUS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; NOCODAZOLE; R-SNARE PROTEINS; RAB3 GTP-BINDING PROTEINS; RABBITS; SUBCELLULAR FRACTIONS;

ADENOVIRIDAE; ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0038445441     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00398     Document Type: Article

References (31)

1. Allan, V. (1996). Motor proteins: a dynamic duo. Curr. Biol. 6, 630-633.
2. Burkhardt, J. K., Echiverri, C. J., Nilsson, T. and Vallee, R. B. (1997). Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J. Cell Biol. 139, 469-484.
3. da Costa, S. R., Yarber, F. A., Zhang, L., Sonee, M. and Hamm-Alvarez, S. F. (1998). Microtubules facilitate the stimulated secretion of β-hexosaminidase in lacrimal acinar cells. J. Cell Sci. 111, 1267-1276.
4. Dartt, D. A. (1994). Signal transduction and activation of the lacrimal gland. In Principles and Practice of Ophthalmology, 2nd edn (ed. D. M. Albert and F. A. Jacobiec), pp. 458-465. Philadelphia: Saunders.
5. Echiverri, C. J., Paschal, B. M., Vaughan, K. T. and Vallee, R. B. (1996). Molecular characterization of the 50 kD subunit of dynactin reveals functions for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132, 617-633.
6. Fischer von Mollard, G., Stahl, B., Li, C., Sudhof, T. C. and Jahn, R. (1994). Rab proteins in regulated exocytosis. Trends Biochem. Sci. 19, 164-168.
7. Fujita-Yoshigaka, J., Dohke, Y., Hara-Yokoyama, M., Kamata, Y., Kozaki, S., Furuyama, S. and Sugiya, H. (1996). Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis in rat parotid acinar cells. J. Biol. Chem. 271, 13130-13134.
8. Fullard, R. (1994). Tear proteins arising from lacrimal tissue. In Principles and Practice of Ophthalmology. 2nd edn (ed. D. M. Albert and F. A. Jacobiec), pp. 473-479. Philadelphia: Saunders.
9. Gaisano, Y. Y., Sheu, L., Foskett, J. K. and Trimble, W. S. (1994). Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion. J. Biol. Chem. 269, 17062-17066.
10. Gierow, J. P., Yang, T., Bekmezian, A., Liu, N., Norian, J. M., Kim, S. A., Rafisolyman, S., Wood, R. L. and Mircheff, A. K. (1996). Na,K-ATPase in lacrimal gland acinar cell endosomal system. Correcting a case of mistaken identity. Am. J. Physiol. 271, C1685-C1698.
11. Gill, S. R., Schroer, T. A., Szilak, I., Steuer, E. R., Sheetz, M. P. and Cleveland, D. W. (1991). Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol. 115, 1639-1650.
12. Goltz, J. S., Wolkoff, A. W., Novikoff, P. M., Stockert, R. J. and Satir, P. (1992). A role for microtubules in sorting endocytic vesicles in rat hepatocytes. Proc. Natl. Acad. Sci. USA 89, 7026-7030.
13. Hamm-Alvarez, S. F., da Costa, S. R., Yang, T., Wei, X., Gierow, J. P. and Mircheff, A. K. (1997). Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein β-hexosaminidase, and activation of soluble kinesin. Exp. Eye Res. 64, 141-156.
14. Hansen, N. J., Antonin, W. and Edwardson, J. M. (1999). Identification of SNAREs involved in regulated exocytosis in the pancreatic acinar cell. J. Biol. Chem. 274, 22871-22876.
15. Hirokawa, N. (1998). Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279, 519-526.
16. Hollenbeck, P. J. (1989). The distribution, abundance and subcellular localization of kinesin. J. Cell Biol. 108, 2335-2342.
17. Holleran, E. A., Karki, S. and Holzbaur, E. L. F. (1998). The role of the dynactin complex in intracellular motility. Int. Rev. Cytol. 182, 69-109.
18. Holzbaur, E. L. F. and Vallee, R. B. (1994). Dyneins: molecular structure and cellular function. Annu. Rev. Cell Biol. 10, 339-372.
19. Mendell, J. R. and Whitaker, J. N. (1978). Immunocytochemical localization studies of myelin basic protein. J. Cell Biol. 76, 502-511.
20. Mircheff, A. K. (1989). Isolation of plasma membranes from polar cells and tissues: apical/basolateral separation, purity, and function. Methods Enzymol. 172, 18-34.
21. Ohnishi, H., Ernst, S. A., Wys, N., McNiven, M. and Williams, J. A. (1996). Rab3D localizes to zymogen granules in rat pancreatic acini and other exocrine glands. Am. J. Physiol. 271, G531-G538.
22. Qian, L., Yang, T., Chen, H. S., Xie, J., Zeng, H., Warren, D. W., MacVeigh, M., Hamm-Alvarez, S. F. and Mircheff, A. K. (2002). Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp. Eye Res. 74, 7-22.
23. Robin, P., Rossignol, B. and Raymond, M. N. (1995). Effect of microtubule network disturbance by nocodazole and docetaxel (Taxotere) on protein secretion in rat extraorbital lacrimal and parotid glands. Eur. J. Cell Biol. 67, 227-237.
24. Schafer, D. A., Gill, S. R., Cooper, J. A., Heuser, J. E. and Schroe, T. A. (1994). Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. J. Cell Biol. 126, 403-412.
25. Schroer, T. A. (1996). Structure and function of dynactin. Semin. Cell Biol. 7, 321-328.
26. Thurig, L., van Herringen, N. J. and Wijngaards, G. (1984). Comparison of enzymes of tears, lacrimal gland fluid and lacrimal gland tissue in the rat. Exp. Eye Res. 38, 605-609.
27. Valentijn, J. A., Sengupta, D., Gumkowski, F. D., Tang, L. H., Konieczko, E. M. and Jamieson, J. D. (1996). Rab3D localizes to secretory granules in rat pancreatic acinar cells. Eur. J. Cell Biol. 70, 33-41.
28. Glued. J. Cell Biol. 131, 1507-1516.
29. Vaughan, K. T., Hyman, S. H., Faulkner, N. E., Echeverri, C. J. and Vallee, R. B. (1999). Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends. J. Cell Sci. 112, 1437-1447.
30. Glued binds directly to both the microtubule and centractin. Proc. Natl. Acad. Sci. USA 92, 1634-1638.
31. Yang, T., Zeng, H., Zhang, J., Okamoto, C. T., Warren, D. W., Wood, R. L., Bachmann, M. and Mircheff, A. K. (1999). Major histocompatibility complex class II molecules, cathepsins B and D, and La/SSB proteins in lacrimal gland acinar cell endomembranes. Am. J. Physiol. 277, C994-C1007.