Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity

FEMS Immunology and Medical Microbiology

Volumn 37, Issue 2-3, 2003, Pages 173-177

  Schulze, Kai ^a   Guzmán, Carlos A ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Fibronectin binding; Mucosal adjuvant; Streptococcus pyogenes

Indexed keywords

ADJUVANT; ANTIGEN; AROMATIC COMPOUND; BACTERIAL PROTEIN; BETA GALACTOSIDASE; FIBRONECTIN; FIBRONECTIN BINDING PROTEIN 1; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; PROLINE; PROTEIN DERIVATIVE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; DRUG SCREENING; EVALUATION; IMMUNIZATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; STIMULATION; STREPTOCOCCUS PYOGENES;

EID: 0038433310     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(03)00071-3     Document Type: Article

References (14)

1. George-Chandy A., Mielcarek N., Nordstrom I., Holmgren J., Eriksson K. Vaccination with Bordetella pertussis-pulsed autologous or heterologous dendritic cells induces a mucosal antibody response in vivo and protects against infection. Infect. Immun. 69:2001;4120-4124.
2. Holmgren J., Czerkinsky C., Lycke N., Svennerholm A.M. Mucosal immunity: implications for vaccine development. Immunobiology. 184:1992;157-179.
3. Hvalbye B.K., Aaberge I.S., Lovik M., Haneberg B. Intranasal immunization with heat-inactivated Streptococcus pneumoniae protects mice against systemic pneumococcal infection. Infect. Immun. 67:1999;4320-4325.
4. Douce G., Turcotte C., Cropley I., Roberts M., Pizza M., Domenghini M., Rappuoli R., Dougan G. Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc. Natl. Acad. Sci. USA. 92:1995;1644-1648.
5. Holmgren J., Lycke N., Czerkinsky C. Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine. 11:1993;1179-1184.
6. Yamamoto S., Takeda Y., Yamamoto M., Kurazono H., Imaoka K., Yamamoto M., Fujihashi K., Noda M., Kiyono H., McGhee J.R. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J. Exp. Med. 185:1997;1203-1210.
7. van Ginkel F.W., Jackson R.J., Yuki Y., McGhee J.R. Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J. Immunol. 165:2000;4778-4782.
8. Medina E., Talay S.R., Chhatwal G.S., Guzmán C.A. Fibronectin-binding protein I of Streptococcus pyogenes is a promising adjuvant for antigens delivered by mucosal route. Eur. J. Immunol. 28:1998;1069-1077.
9. Medina E., Talay S.R., Chhatwal G.S., Guzman C.A. Fibronectin-binding protein I of Streptococcus pyogenes promotes T cell-independent proliferation of murine B lymphocytes and enhances the expression of MHC class II molecules on antigen-presenting cells. Int. Immunol. 10:1998;1657-1664.
10. Guzmán C.A., Talay S.R., Molinari G., Medina E., Chhatwal G.S. Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI. J. Infect. Dis. 179:1999;901-906.
11. Molinari G., Talay S.R., Valentin Weigand P., Rohde M., Chhatwal G.S. The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of group A streptococci by epithelial cells. Infect. Immun. 65:1997;1357-1363.
12. Braun M.C., He J., Wu C.Y., Kelsall B.L. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J. Exp. Med. 189:1999;541-552.
13. Elson C.O., Holland S.P., Dertzbaugh M.T., Cuff C.F., Anderson A.O. Morphologic and functional alterations of mucosal T cells by cholera toxin and its B subunit. J. Immunol. 154:1995;1032-1040.
14. Munoz E., Zubiaga A.M., Merrow M., Sauter N.P., Huber B.T. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:1990;95-103.