The effects of benzimidazole anthelmintics on P4501A in rat hepatocytes and HepG2 cells

Research in Veterinary Science

Volumn 75, Issue 1, 2003, Pages 61-69

  Baliharova V ^a   Skalova L ^a   Maas, R F M ^b   De Vrieze, G ^b   Bull, S ^b   Fink Gremmels, J ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Benzimidazole anthelmintics; Cytochromes P4501A; Enzyme induction; HepG2 cells; Rat hepatocytes

Indexed keywords

ALBENDAZOLE; ANTHELMINTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CYTOCHROME P450 1A; ETHOXYRESORUFIN DEETHYLASE; FENBENDAZOLE; MEBENDAZOLE; METHOXYRESORUFIN DEMETHYLASE; O DEMETHYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STUDENT T TEST; VETERINARY MEDICINE; WESTERN BLOTTING;

EID: 0038422118     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5288(03)00033-X     Document Type: Article

References (28)

1. Asteinza, J., Camacho-Carranza, R., Reyes-Reyes, R.E., Dorado-Gonzáles, V., Espinosa-Aguirre, J.J., 2000. Induction of cytochrome P450 enzymes by albendazole treatment in the rat. Environmental Toxicology and Pharmacology 9, 31-37.
2. Backlund, M., Weidolf, L., Ingelman-Sundberg, M., 1999. Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. European Journal of Biochemistry 261, 66-71.
3. Boobis, A.R., Sesardic, D., Murray, B.P., Edwards, R.J., Singleton, A,M., Rinch, K.J., Murray, S., De La Torre, R., Segura, J., Pelkonen, O., Pasanen, M., Kobayshi, S., Zhi-Guang, T., Davies, D.S., 1990. Species variation in the response of the cytochrome P450-dependent monooxygenase system to inducers and inhibitors. Xenobiotica 20, 1139-1161.
4. Burke, M.D., Thompson, S., Weaver, R.J., Wolf, C.R., Mayer, R.T., 1994. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochemical Pharmacology 48, 923-936.
5. Curi-Pedrosa, R., Daujat, M., Pichard, L., Ourlin, J.C., Clair, P., Gervot, L., Lesca, P., Domergue, J., Joyeux, H., Fourtanier, G., Maurel, P., 1994. Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture. The Journal of Pharmacology and Experimental Therapeutics 269, 384-392.
6. Denizat, F., Lang, R., 1986. Rapid colorimetric assay for cell growth and survival. Journal of Immunology Methods 89, 271-277.
7. Doostdar, H., Grant, M.H., Melvin, W.T., Wolf, C.R., Burke, M.D., 1993. The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells. Biochemical Pharmacology 46, 629-635.
8. Gleizes-Escala, C., Eeckhoutte, C., Pineau, T., Alvinerie, M., Galtier, P., 1991. Inducing effect of oxfendazole on cytochrome P4501A2 in rabbit liver. Consequences on cytochrome P450 dependent monooxygenases. Biochemical Pharmacology 41, 1813-1820.
9. Gleizes-Escala, C., Lesca, P., Larrieu, G., Dupuy, J., Pineau, T., Galtier, P., 1996. Effect of exposure of rabbit hepatocytes to sulfur-containing anthelmintics (oxfendazole and fenbendazole) on cytochrome P4501A1 expression. Toxicology in Vitro 10, 129-139.
10. Gottmanns, H., Kroker, R., Ungemach, F.R., 1991. Investigations on the biotransformation of mebendazole using an isolated perfused rat gut system. Xenobiotica 21, 1431-1439.
11. Higa, F., Kitsukawa, K., Gaja, M., Tateyama, M., Shikiya, K., Shigeno, Y., Kinjo, F., Saito, A., 1992. Cytotoxicity of mebendazole against established cell lines from the human, rat, and mouse liver. Archives of toxicology 66, 224-227.
12. Kikuchi, H., Hossain, A., Yoshida, H., Kobayashi, S., 1998. Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by -naphthoflavone. Archives of Biochemistry and Biophysics 358, 351-358.
13. Krusekopf, S., Kleeberg, U., Hildebrandt, A.G., Ruckpaul, K., 1997. Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line. Xenobiotica 27, 1-9.
14. Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
15. Montesissa, C., Anfossi, P., Van't Klooster, G., Mendgelers, M., 1996. The use of cultured hepatocytes from goats and cattle to investigate xenobiotic oxidative metabolism. Veterinary Research Communications 20, 449-460.
16. Moroni, P., Buronfosse, T., Longin-Sauvageon, C., Delatour, P., Benoit, E., 1995. Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. Drug Metabolism and Disposition 23, 160-165.
17. Paine, A.J., 1990. The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chemical-Biological Interactions 74, 1-31.
18. Parke, D.V., Ioannides, C., Lewis, D.F.V., 1990. Computer modelling and in vitro test in the safety evaluation of chemicals - strategic applications. Toxicology In Vitro 4, 680.
19. Rey-Grobellet, X., Ferre, N., Eeckhoutte, C., Larrieu, G., Pineau, T., Galtier, P., 1996. Structural requirements for the induction of cytochrome P450 by benzimidazole anthelmintic derivatives in cultured rabbit hepatocytes. Biochemical and Biophysical Research Communications 220, 789-794.
20. Rolin, S., Amri, H.S.-E., Batt, A.-M., Levy, M., Bagrel, D., Siest, G., 1989. Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatome cell lines. Cell Biology and Toxicology 5, 1-14.
21. Russell, G.J., Gill, J.H., Lacey, E., 1992. Binding of [3H]benzimidazole carbamates to mammalian brain tubulin and the mechanism of selective toxicity of the benzimidazole anthelmintics. Biochemical Pharmacology 43, 1095-1100.
22. Seglen, P.O., 1976. Preparation of isolated rat liver cells. In: Prescott, D.M. (Ed.), Methods in Cell Biology, vol. XIII. Academic Press, New York, pp. 29-78.
23. Souhaili-El Amri, H., Fargetton, X., Benoit, E., Totis, M., Batt, A.M., 1988. Inducing effect of albendazole on rat liver drug-metabolising enzymes metabolite pharmacokinetics. Toxicology and Applied Pharmacology 92, 141-149.
24. Towbin, H., Staehelin, T., Gordon, J., 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceeding of the National Academy of Sciences USA 76, 4350-4354.
25. Whittaker, S.G., Faustman, E.M., 1991. Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells. Toxicology and Applied Pharmacology 109, 73-84.
26. Whittaker, S.G., Faustman, E.M., 1992. Effects of benzimidazole analogs on cultures of differentiating rodent embryonic cells. Toxicology and Applied Pharmacology 113, 144-151.
27. Wortelboer, H.M., De Kruif, C.A., Van Iersel, A.A.J., Falke, H.E., Noordhoek, J., Blaauboer, B.J., 1990. The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers. Biochemical Pharmacology 40, 2525-2534.
28. Wortelboer, H.M., De Kruif, C.A., Van. Iersel, A.A.J., Falke, H.E., Noordhoek, J., Blaauboer, B.J., 1991. Comparison of cytochrome P450 isoenzymes profiles in rat liver and hepatocyte cultures: the effects of model inducers on apoproteins and biotransformation activities. Biochemical Pharmacology 42, 381-390.