Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line

Xenobiotica

Volumn 27, Issue 1, 1997, Pages 1-9

  Krusekopf, S ^a   Kleeberg, U ^b   Hildebrandt, A G ^b   Ruckpaul, K ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Fed Inst Drugs and Med Devices   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; BETA NAPHTHOFLAVONE; CYTOCHROME P450 ISOENZYME; LANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; RABEPRAZOLE;

ARTICLE; CELL CULTURE; CELL LINE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NORTHERN BLOTTING;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; BENZIMIDAZOLES; BETA-NAPHTHOFLAVONE; CELL LINE; CYTOCHROME P-450 CYP1A1; ENZYME ACTIVATION; HUMANS; OMEPRAZOLE; RNA, MESSENGER; SULFOXIDES;

EID: 0031032327     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982597240721     Document Type: Article

References (53)

1. BELLOC, C., BAIRD, S., COSME, J., LECOEUR, S., GAUTIER, J.-C., CHALLINE, D., DE WAZIERS, I., FLINOIS, J.-P. and BEAUNE, P. H., 1996, Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies. Toxicology, 106, 207-219.
2. BOLT, H. M., 1994, Interactions between clinically used drugs and oral contraceptives. Environmental Health Perspectives, 102, 35-38.
3. BOUCER, P. D. and HINES, R. N., 1995, In vitro binding and functional studies comparing the human CYP1A1 negative regulatory element with the orthologous sequences from rodent genes. Carcinogenesis, 16, 383-392.
4. CHASSEROT-GOLAZ, S. and BECK, G., 1992, How the potency of the steroid RU486 is related to P450 activities induced by dexamethasone and phenobarbital in rat hepatoma cells. Journal of Steroid Biochemistry and Molecular Biology, 41, 653-657.
5. CHUNG, I. and BRESNICK, E., 1994, 3-Methylcholanthrene-mediated induction of cytochrome P4501A2 in human hepatoma HepG2 cells as quantified by the reverse transcription-polymerase chain reaction. Archives of Biochemistry and Biophysics, 314, 75-81.
6. CURI-PEDROSA, R., DAUJAT, M., PICARD, L., OURLIN, J. C., CLAIR, P., GERVOT, L., LESCA, P., DOMERGUE, J., JOYEUX, H., FOURTANIER, G. and MAUREL, P., 1994, Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture. Journal of Pharmacology and Experimental Therapeutics, 269, 384-392.
7. DAUJAT, M., PERYT, B., LESCA, P., FOURTANIER, G., DOMERGUE, J. and MAUREL, P., 1992, Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the AH receptor. Biochemical and Biophysical Research Communications, 188, 820-825.
8. DE MEY, C., MEINEKE, I., STEINIJANS, V. W., HUBER, R., HARTMANN, M., BLIESATH, H. and WURST, W., 1994, Pantoprazole lacks interaction with antipyrine in man, either by inhibition or induction. International Journal of Clinical Pharmacology and Therapeutics, 32, 98-106.
9. DIAZ, D., FABRE, I., DAUJAT, M., SAINT-AUBERT, B., BORIES, P., MICHEL, H. and MAUREL, P., 1990, Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology, 99, 737-747.
10. DONATO, M. T., CASTELL, J. V. and GÓMEZ-LECHÓN, M. J., 1994, Cytochrome P450 activities in pure and co-cultured rat hepatocytes. Effects of model inducers. In Vitro Cellular and Developmental Biology, 30A, 825-832.
11. DONATO, M. T., HERRERO, E., GÓMEZ-LECHÓN, M. J. and CASTELL, J. V., 1993, Inhibition of monooxygenase activities in human hepatocytes by interferons. Toxicology in Vitro, 7, 481-485.
12. DOOSTDAR, H., DUTHIE, S. J., BURKE, M. D., MELVIN, W. T. and GRANT, M. H., 1988, The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line. FEBS Letters, 241, 15-18.
13. FUKUDA, Y., ISHIDA, N., NOGUSHI, T., KAPPAS, A. and SASSA, S., 1992, Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells. Biochemical and Biophysical Research Communications, 184, 960-965.
14. FUKUDA, Y. and SASSA, S., 1994, Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells. Biochemical Pharmacology, 47, 1187-1195.
15. GONZALEZ, J. G., 1992, Human cytochromes P450: problems and prospects. Trends in Pharmacological Sciences, 13, 346-352.
16. HAYASHI, S., WATANABE, J., NAKACHI, K., EGUCHI, H., GOTOH, O. and KAWAJIRI, K., 1994, Interindividual difference in expression of human Ah receptor and related P450 genes. Carcinogenesis, 15, 801-806.
17. JAISWAL, A. K., GONZALEZ, F. J. and NEBERT, D. W., 1985, Human dioxin-inducible Cytochrome P1-450: complementary DNA and ammo acid sequence. Science, 228, 80-83.
18. KIKUCHI, H., HOSSAIN, A., SAGAMI, I., IKAWA, S. and WATANABE, M., 1995, Different inducibility of cytochrome P-4501A1 mRNA of human and mouse by omeprazole in culture cells. Archives of Biochemistry and Biophysics, 316, 649-652.
19. KIM, N. D., YOO, J. K., WON, S. M., PARK, S. S. and GELBOIN, H. V., 1993, Phenytoin induction of cytochrome P4502B in mice: effects on hexobarbital hydroxylase activity. Xenobiotica, 23, 217-225.
20. KNOWLES, B. B., HOWE, C. C. and ADEN, D. P., 1980, Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science, 209, 497-499.
21. KOCAREK, T. A., SCHUETZ, E. G., STROM, S. C., FISHER, R. A. and GUZELIAN, P. S., 1995, Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metabolism and Disposition, 23, 415-421.
22. KOKUFU, T., IHARA, N., SUGIOKA, N., KOYAMA, H., OHTA, T., MORI, S. and NAKAJIMA, K., 1995, Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. European Journal of Clinical Pharmacology, 48, 391-395.
23. LAEMMLI, U. K., 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
24. LESCA, P., PERYT, B., LARRIEU, G., ALVINERIE, M., GALTIER, P., DAUJAT, M., MAUREL, P. and HOOGENBOOM, L., 1995, Evidence for the ligand-independent activation of the AH receptor. Biochemical and Biophysical Research Communications, 209, 474-482.
25. LIPP, H. P., SCHRENK, D., WIESMULLER, T., HAGENMAIER, H. and BOCK, K. W., 1992, Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins (PCDDs) and their constituents in human HepG2 cells. Archives of Toxicology, 66, 220-223.
26. LUCAS, D., BERTHOU, F., DRÉANO, Y., LOZAC'H, P., VOLANT, A. and MÉNEZ, J.-F., 1993, Comparison of levels of cytochromes P-450, CYP1A2, CYP2E1, and their related monooxygenase activities in human surgical liver samples. Alcoholism : Clinical and Experimental Research, 17, 900-905.
27. MEREDITH, M. J., 1988, Rat hepatocytes prepared without collagenase: prolonged retention of differentiated characteristics in culture. Cell Biology and Toxicology, 4, 405-425.
28. MESNIL, M., FRASLIN, J. M., PICCOLI, C., YAMASAKI, H. and GUGUEN-GUILLOUZO, C., 1987, Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions. Experimental Cell Research, 173, 524-532.
29. NAKAMA, A., KURODA, K. and YAMADA, A., 1995, Induction of cytochrome P450-dependent monooxygenase in serum-free cultured HepG2 cells. Biochemical Pharmacology, 50, 1407-1412.
30. NEDELCHEVA, V. and GUT, I., 1994, P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer. Xenobiotica, 24, 1151-1175.
31. NEMOTO, N. and SAKURAI, J., 1994, Elevated expression of the CYP1a2 gene in the presence of nicotinamide by adult mouse hepatocytes in primary culture. Archives of Biochemistry and Biophysics, 308, 292-298.
32. NEMOTO, N., SAKURAI, J. and FUNAE, Y., 1995, Maintainance of phenobarbital-inducible Cyp2b gene expression in C57BL/6 mouse hepatocytes in primary culture as spheroids. Archives of Biochemistry and Biophysics, 316, 362-369.
33. NOUSBAUM, J. B., BERTHOU, F., CARLHANT, D., RICHE, C., ROBASZKIEWICZ, M. and GOUEROU, H., 1994, Four-week treatment with omeprazole increases the metabolism of caffeine. American Journal of Gastroenterology, 89, 371-375.
34. OLSZEWSKA, E., and JONES, K., 1988, Vacuum blotting enhances nucleic acid transfer. Trends in Genetics, 4, 92-94.
35. PADGHAM, C. R., BOYLE, C. C., WANG, X. J., RALEIGH, S. M., WRIGHT, M. C. and PAINE, A. J., 1993, Alteration of transcription factor mRNAs during the isolation and culture of rat hepatocytes suggests the activation of a proliferative mode underlies their de-differentiation. Biochemical and Biophysical Research Communications, 197, 599-605.
36. PADGHAM, C. R. W. and PAINE, A. J., 1993, Altered expression of cytochrome P-450 mRNAs, and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes. Biochemical Journal, 289, 621-624.
37. PADGHAM, C. R. W., PAINE, A. J., PHILLIPS, I. R. and SHEPHARD, E. A., 1992, Maintenance of total cytochrome p-450 content in rat hepatocyte culture and the abundance of CYP1A2 and CYP2B1/2 mRNAs. Biochemical Journal, 285, 929-932.
38. PONTE, P., NG, S. Y., ENGEL, J., GUNNING, P. and KEDES, L., 1984, Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Research, 12, 1687-1696.
39. PROUGH, R. A., BURKE, M. D. and MAYER, R. T., 1978, Direct fluorometric methods for measuring mixed-function oxidase activity. Methods in Enzymology, 52, 372-377.
40. ROE, A. L., SNAWDER, J. E., BENSON, R. W., ROBERTS, D. W. and CASCIANO, D. A., 1993, HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen. Biochemical and Biophysical Research Communications, 190, 15-19.
41. ROGIERS, V. and VERCRUYSSE, A., 1993, Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology, 82, 193-208.
42. ROST, K. L., BROSICKE, H., BROCKMOLLER, J., SCHEFFLER, M., HELGE, H. and ROOTS, I., 1992, Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-S-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clinical Pharmacology and Therapeutics, 52, 170-180.
43. + ATPase. Annual Review of Pharmacology and Toxicology, 35, 277-305.
44. SAMBROOK, J., FRITSCH, E. F. and MANIATIS, T., 1989, Molecular Cloning (Cold Spring Harbor: Cold Spring Harbor Laboratory Press), 7.40-7.42.
45. SASSA, S., SUGITA, O., GALBRAITH, R. A. and KAPPAS, A., 1987, Drug metabolism by the human hepatoma cell, HepG2. Biochemical and Biophysical Research Communications, 143, 52-57.
46. SCHMALIX, W. A., MASER, H., KIEFER, F., REEN, R., WIEBEL, F. J., GONZALEZ, F., SEIDEL, A., GLATT, H., GREIM, H. and DOEHMER, J., 1993, Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene. European Journal of Pharmacology/Environmental Toxicology and Pharmacology Section, 248, 251-261.
47. SCHWEIKL, H., TAYLOR, J. A., KITAREEWAN, S., LINKO, P., NAGORNEY, D. and GOLDSTEIN, J. A., 1993, Expression of CYP1A1 and CYP1A2 genes in human liver. Pharmacogenetics, 3, 239-249.
48. SIDHU, J. S., FARIN, F. M., KAVANAGH, T. J. and OMIECINSKI, C. J., 1994, Effect of tissue-culture substratum and extracellular matrix overlay on liver-selective and xenobiotic inducible gene expression in primary rat hepatocytes. In Vitro Toxicology, 7, 225-242.
49. +-ATPase inhibitor pantoprazole (BY1023/SK&F96022) interacts less with cytochrome P450 than omeprazole and lansoprazole. Biochemical Pharmacology, 42, 347-355.
50. STEINIJANS, V. W., HUBER, R., HARTMANN, M., ZECH, K., BLIESATH, H., WURST, W. and RADTKE, H. W., 1994, Lack of pantoprazole drug interactions in man. International Journal of Clinical Pharmacology and Therapeutics, 32, 385-399.
51. THOMAS, H., SAGELSDORF, P., MOLITOR, E., SKRIPSKY, T. and WÄCHTER, F., 1994, Bromopropylate: induction of hepatic cytochromes P450 and absence of covalent binding to DNA in mouse liver. Toxicology and Applied Pharmacology, 129, 155-162.
52. UTESCH, D., MOLITOR, E., PLATT, K.-L. and OESCH, F., 1991, Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells. In Vitro Cellular and Developmental Biology, 27A, 858-863.
53. VENKATESAN, K., 1992, Pharmacokinetic drug interactions with rifampicin. Clinical Pharmacokinetics, 22, 47-65.