Mycoplasma disease and acute chest syndrome in sickle cell disease

Pediatrics

Volumn 112, Issue 1 I, 2003, Pages 87-95

  Neumayr, Lynne ^a   Lennette, Evelyne ^b   Kelly, Dana ^a   Earles, Ann ^a   Embury, Stephen ^c   Groncy, Paula ^d   Grossi, Mauro ^e   Grover, Ranjeet ^f   McMahon, Lillian ⁱ   Swerdlow, Paul ^g   Waldron, Peter ^h   Vichinsky, Elliott ^a  

^a CHILDREN S HOSPITAL OAKLAND   (United States)

^b Virolab Inc   (United States)

^c SAN FRANCISCO GENERAL HOSPITAL   (United States)

^d LONG BEACH MEMORIAL MEDICAL CENTER   (United States)

^e CHILDREN S HOSPITAL OF BUFFALO   (United States)

^f ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^g WAYNE STATE UNIVERSITY   (United States)

^h UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

ⁱ BOSTON MEDICAL CENTER   (United States)

Author keywords

Acute chest syndrome; Mycoplasma hominis; Mycoplasma pneumoniae; Pneumonia; Pulmonary fat embolism; Sickle cell

Indexed keywords

BRONCHODILATING AGENT; CEPHALOSPORIN; ERYTHROMYCIN; IMMUNOGLOBULIN G ANTIBODY; MACROLIDE;

ACUTE CHEST SYNDROME; ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; ASSISTED VENTILATION; ATELECTASIS; BACTERIAL INFECTION; BLOOD CULTURE; BLOOD TRANSFUSION; BRONCHOSCOPY; CHILD; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; COUGHING; DISEASE ASSOCIATION; DISEASE COURSE; FAT EMBOLISM; FEMALE; FEVER; HUMAN; INFANT; LEGIONELLA PNEUMOPHILA; LENGTH OF STAY; LUNG INFILTRATE; MAJOR CLINICAL STUDY; MALE; MYCOPLASMA HOMINIS; MYCOPLASMA PNEUMONIAE; PLEURA EFFUSION; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; SICKLE CELL ANEMIA; SPUTUM CULTURE; TACHYPNEA; THORAX PAIN; TREATMENT OUTCOME; WHEEZING;

ACUTE DISEASE; ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; BACTEREMIA; CHEST PAIN; CHILD; CHILD, PRESCHOOL; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; FEMALE; FEVER; HUMANS; INFANT; MALE; MIDDLE AGED; MYCOPLASMA HOMINIS; MYCOPLASMA INFECTIONS; MYCOPLASMA PNEUMONIAE; PNEUMONIA, BACTERIAL; PNEUMONIA, MYCOPLASMA; PROSPECTIVE STUDIES; RESPIRATION DISORDERS; SEROEPIDEMIOLOGIC STUDIES; SYNDROME; TREATMENT OUTCOME;

EID: 0038419526     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.112.1.87     Document Type: Article

References (128)

1. Vichinsky EP, Neumayr LD, Earles AN, et al. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. [erratum appears in N Engl J Med 2000 Sep 14;343:824]. N Engl J Med. 2000;342:1855-1865
2. Block S, Hedrick J, Hammerschlag MR, Cassell GH, Craft JC. Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate. Pediatr Infect Dis J. 1995;14:471-477
3. Bochud PY, Moser F, Erard P, et al. Community-acquired pneumonia. A prospective outpatient study. Medicine (Baltimore). 2001;80:75-87
4. Drummond P, Clark J, Wheeler J, Galloway A, Freeman R, Cant A. Community acquired pneumonia - a prospective UK study. Arch Dis Child. 2000;83:408-412
5. Foy HM. Mycoplasma pneumoniae pneumonia: current perspectives. Clin Infect Dis. 1999;28:237
6. Fine MJ, Smith MA, Carson CA, et al. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA. 1996;275:134-141
7. Chan CH, Cohen M, Pang J. A prospective study of community-acquired pneumonia in Hong Kong. Chest. 1992;101:442-446
8. Harris JA, Kolokathis A, Campbell M, Cassell GH, Hammerschlag MR. Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children. Pediatr Infect Dis J. 1998;17:865-871
9. Heiskanen-Kosma T, Korppi M, Jokinen C, et al. Etiology of childhood pneumonia: serologic results of a prospective, population-based study. Pediatr Infect Dis J. 1998;17:986-991
10. Juven T, Mertsola J, Waris M, et al. Etiology of community-acquired pneumonia in 254 hospitalized children. Pediatr Infect Dis J. 2000;19:293-298
11. Lim WS, Macfarlane JT, Boswell TC, et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax. 2001;56:296-301
12. Marrie TJ, Peeling RW, Fine MJ, Singer DE, Coley CM, Kapoor WN. Ambulatory patients with community-acquired pneumonia: the frequency of atypical agents and clinical course. Am J Med. 1996;101:508-515
13. Murphy TF, Henderson FW, Clyde WA, Jr, Collier AM, Denny FW. Pneumonia: an eleven-year study in a pediatric practice. Am J Epidemiol. 1981;113:12-21
14. Patel T, Pearl J, Williams J, Haverstock D, Church D. Efficacy and safety of ten day moxifloxacin 400 mg once daily in the treatment of patients with community-acquired pneumonia. Community Acquired Pneumonia Study Group. Respir Med. 2000;94:97-105
15. Sopena N, Sabria M, Pedro-Botet ML, et al. Prospective study of community-acquired pneumonia of bacterial etiology in adults. Eur J Clin Microbiol Infect Dis. 1999;18:852-858
16. Waris ME, Toikka P, Saarinen T, et al. Diagnosis of Mycoplasma pneumoniae pneumonia in children. J Clin Microbiol. 1998;36:3155-3159
17. Wubbel L, Muniz L, Ahmed A, et al. Etiology and treatment of community-acquired pneumonia in ambulatory children. Pediatr Infect Dis J. 1999;18:98-104
18. Claesson BA, Trollfors B, Brolin I, et al. Etiology of community-acquired pneumonia in children based on antibody responses to bacterial and viral antigens. Pediatr Infect Dis J. 1989;8:856-862
19. Ruiz-Gonzalez A, Falguera M, Nogjes A, Rubio-Caballero M. Is Streptococcus pneumoniae the leading cause of pneumonia of unknown etiology? A microbiologic study of lung aspirates in consecutive patients with community-acquired pneumonia. Am J Med. 1998;106:385-390
20. Mezarina KB, Huffmire A, Downing J, Core N, Gersham K, Hoffman R, from the Centers for Disease Control and Prevention. Outbreak of community-acquired pneumonia caused by Mycoplasma pneumoniae Colorado, 2000. JAMA. 2001;285:2073-2074
21. Evatt BL, Dowdle WR, Johnson M, Jr, Heath CW, Jr. Epidemic Mycoplasma pneumonia. N Engl J Med. 1971;285:374-378
22. Foy HM, Kenny GE, McMahan R, Mansy AM, Grayston JT. Mycoplasma pneumoniae pneumonia in an urban area. JAMA. 1970;214:1666-1672
23. Cimolai N, Wensley D, Seear M, Thomas ET. Mycoplasma pneumoniae as a cofactor in severe respiratory infections. Clin Infect Dis. 1995;21:1182-1185
24. Chian CF, Chang FY. Acute respiratory distress syndrome in Mycoplasma pneumonia: a case report and review. J Microbiol Immunol Infect. 1999;32:52-56
25. Chan ED, Welsh CH. Fulminant Mycoplasma pneumoniae pneumonia. West J Med. 1995;162:133-142
26. Chapman RS, Henderson FW, Clyde WA, Collier AM, Denny FW. The epidemiology of tracheobronchitis in pediatric practice. Am J Epidemiol. 1981;114:786-797
27. Hanhan U, Oriowski J, Fiallos M. Association of Mycoplasma pneumonia infections with status asthmaticus. Pediatrics. 1999;104:680
28. Kraft M, Cassell GH, Henson JE, et al. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. [erratum appears in Am J Respir Crit Care Med 1998 Nov;158:1692]. Am J Respir Crit Care Med. 1998;158:998-1001
29. Lamont J, Verbeken E, Verschakelen J, Demedts M. Bronchiolitis obliterans organising pneumonia. A report of 11 cases and a review of the literature. Acta Clin Belg. 1998;53:328-336
30. Chan PW, Muridan R, Debruyne JA. Bronchiolitis obliterans in children: clinical profile and diagnosis. Respirology. 2000;5:369-375
31. Radisic M, Torn A, Gutierrez P, Defranchi HA, Pardo P. Severe acute lung injury caused by Mycoplasma pneumoniae: potential role for steroid pulses in treatment. Clin Infect Dis. 2000;31:1507-1511
32. Shah DC, Muthiah MM. Adult respiratory distress syndrome due to Mycoplasma pneumonia. Postgrad Med J. 1996;72:241-242
33. Sands MJ, Jr, Satz JE, Turner WE, Jr, Soloff LA. Pericarditis and perimyocarditis associated with active Mycoplasma pneumoniae infection. Ann Intern Med. 1977;86:544-548
34. Kenney RT, Li JS, Clyde WA, Jr, et al. Mycoplasmal pericarditis: evidence of invasive disease. Clin Infect Dis. 1993;17(Suppl 1):S58-S62
35. Meseguer MA, Perez-Molina JA, Fernandez-Bustamante J, Gomez R, Martos I, Quero MC. Mycoplasma pneumoniae pericarditis and cardiac tamponade in a ten-year-old girl. Pediatr Infect Dis J. 1996;15:829-831
36. Mattila PS, Carlson P, Sivonen A, et al. Life-threatening Mycoplasma hominis mediastinitis. Clin Infect Dis. 1999;29:1529-1537
37. Haier J, Nasralla M, Franco AR, Nicolson GL. Detection of mycoplasmal infections in blood of patients with rheumatoid arthritis. Rheumatologay (Oxford). 1999;38:504-509
38. Poggio TV, Orlando N, Galanternik L, Grinstein S. Microbiology of acute arthropathies among children in Argentina: Mycoplasma pneumoniae and hominis and Ureaplasma urealyticum. Pediatr Infect Dis J. 1998;17:304-308
39. Nathan MD. Stevens-Johnson syndrome: twenty-three cases and their otolaryngologic significance. Laryngoscope. 1975;85:1713-1724
40. Villiger RM, von Vigier RO, Ramelli GP, Hassink RI, Bianchetti MG. Precipitants in 42 cases of erythema multiforme. Eur J Pediatr. 1999;158:929-932
41. Cribier B, Caille A, Heid E, Grosshans E. Erythema nodosum and associated diseases. A study of 129 cases. Int J Dermatol. 1998;37:667-672
42. Bitnun A, Ford-Jones EL, Petric M, et al. Acute childhood encephalitis and Mycoplasma pneumoniae. Clin Infect Dis. 2001;32:1674-1684
43. Dionisio D, Valassina M, Mata S, et al. Encephalitis caused directly by Mycoplasma pneumoniae. Scand J Infect Dis. 1999;31:506-509
44. Ieven M, Demey H, Ursi D, Van Goethem G, Cras P, Goossens H. Fatal encephalitis caused by Mycoplasma pneumoniae diagnosed by the polymerase chain reaction. Clin Infect Dis. 1998;27:1552-1553
45. Kolski H, Ford-Jones EL, Richardson S, et al. Etiology of acute childhood encephalitis at The Hospital for Sick Children, Toronto, 1994-1995. Clin Infect Dis. 1998;26:398-409
46. Benito-Leon J, Guerrero AL, Simon R, Mateos F. Ischemic stroke in children. Revista de Nerologia. 1998;27:631-634
47. Koletsky RJ, Weinstein AJ. Fulminant Mycoplasma pneumoniae infection. Report of a fatal case, and a review of the literature. Am Rev Respir Dis. 1980;122:491-496
48. Chusid MJ, Lachman BS, Lazerson J. Severe Mycoplasma pneumonia and vesicular eruption in SC hemoglobinopathy. J Pediatr. 1978;93:449-451
49. Davies SC, Luce PJ, Win AA, Riordan JF, Brozovic M. Acute chest syndrome in sickle-cell disease. Lancet. 1984;1:36-38
50. Lobel JS, Sturm R, Carroll WL, Limouze SC. Mycoplasma pneumonia in a 15-month-old girl with hemoglobin SC disease. Am J Pediatr Hematol-Oncol. 1981;3:444-446
51. Maitre B, Habibi A, Roudot-Thoraval F, et al. Acute chest syndrome in adults with sickle cell disease. Chest. 2000;117:1386-1392
52. Miller ST, Hammerschlag MR, Chirgwin K, et al. Role of Chlamydia pneumoniae in acute chest syndrome of sickle cell disease. J Pediatr. 1991;118:30-33
53. Shulman ST, Bartlett J, Clyde WA, Jr, Ayoub EM. The unusual severity of Mycoplasmal pneumonia in children with sickle-cell disease. N Engl J Med. 1972;287:164-167
54. Raouf H, Balkis M, Emna G, et al. Complications pulmonaires au cours des syndromes drepanocytaires. Tunis Med. 2000;78:176-180
55. Srair HA, Owa JA, Aman HA, Madan MA. Acute chest syndrome in children with sickle cell disease. Indian J Pediatr. 1995;62:201-205
56. Waites KB, Taylor-Robinson D. Mycoplasma and Ureaplasma. In: Murray PR, ed. Manual of Clinical Microbiology. 7th ed. Washington DC: ASM Press; 1999:782-806
57. Landry ML, Hsiung GD. Primary isolation of viruses. In: Spector S, Lancz G, eds. Clinical Virology Manual. 2nd ed. New York, NY: Elsevier Science Publishing; 1992:43-69
58. Lennette ET, Lennette DA. Immune adherence hemagglutination. In: Specter SLG, ed. Clinical Virology Manual. 2nd ed. New York: Elsevier Science Publishing; 1992:251-261
59. Robinson DT. Mycoplasma and Ureaplasma. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, eds. Manual of Clinical Microbiology. 6th ed. Washington, DC: ASM Press; 1995:652-662
60. Kajigaya S, Shimada T, Fujita S, Young NS. A genetically engineered cell linje that produces empty capsids of B19 (human) parvovirus. Proc Natl Acad Sci U S A. 1989;86:7601-7605
61. Lennette ET. Epstein-Barr virus. Manual of Clinical Microbiology. 7th ed. Washington DC: ASM Press; 1999:912-918
62. Schachter J. Chlamydia. In: Balows A, Hausler WJJ, Hermann KL, Isenberg HD, Shadomy HJ, eds. Manual of Clinical Microbiology. 5th ed. Washington DC: ASM Press; 1991:1045-1053
63. Lietman T, Brooks D, Moncada J, Schachter J, Dawson C, Dean D. Chronic follicular conjuncitivitis associated with Chlamydia psittaci or Chlamydia pneumoniae. Clin Infect Dis. 1998;26:1335-1340
64. Vichinsky E, Williams R, Das M, et al. Pulmonary fat embolism: a distinct cause of severe acute chest syndrome in sickle cell anemia. Blood. 1994;83:3107-3112
65. Kenny GE. Mycoplasmas. In: Balows A, Hausler WJJ, Herrmann KL, Isenberg HD, Shadomy HJ, eds. Manual of Clinical Microbiology. 5th ed. Washington DC: American Society for Microbiology; 1991:478-481
66. Dorigo-Zetsma JW, Zaat SA, Wertheim-van Dillen PM, et al. Comparison of PCR, culture, and serological tests for diagnosis of Mycoplasma pneumoniae respiratory tract infection in children. J Clin Microbiol. 1999;37:14-17
67. Abele-Horn M, Busch U, Nitschko H, et al. Molecular approaches to diagnosis of pulmonary diseases due to Mycoplasma pneumoniae. J Clin Microbiol. 1998;36:548-551
68. Freymuth F, Vabret A, Brouard J, et al. Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children. J Clin Virol. 1999;13:131-139
69. Hardegger D, Nadal D, Bossart W, Altwegg M, Dutly F. Rapid detection of Mycoplasma pneumoniae in clinical samples by real-time PCR. J Microbiol Methods. 2000;41:45-51
70. Menendez R, Cordoba J, de La Cuarda P, et al. Value of the polymerase chain reaction assay in noninvasive respiratory samples for diagnosis of community-acquired pneumonia. Am J Respir Crit Care Med. 1999;159:1868-1873
71. Skakni L, Sardet A, Just J, et al. Detection of Mycoplasma pneumoniae in clinical samples from pediatric patients by polymerase chain reaction. J Clin Microbiol. 1992;30:2638-2643
72. Delatte SJ, Hebra A, Tagge EP, Jackson S, Jacques K, Othersen HB, Jr. Acute chest syndrome in the postoperative sickle cell patient. J Pediatr Surg. 1999;34:188-191; discussion 191-182
73. Mallouh AA, Asha M. Beneficial effect of blood transfusion in children with sickle cell chest syndrome. Am J Dis Child. 1988;142:178-182
74. Sprinkle RH, Cole T, Smith S, Buchanan GR. Acute chest syndrome in children with sickle cell disease. A retrospective analysis of 100 hospitalized cases. Am J Pediatr Hematol-Oncol. 1986;8:105-110
75. Poncz M, Kane E, Gill FM. Acute chest syndrome in sickle cell disease: etiology and clinical correlates. J Pediatr. 1985;107:861-866
76. Ruuskanen O, Nohynek H, Ziegler T, et al. Pneumonia in childhood: etiology and response to antimicrobial therapy. Eur J Clin Microbiol Infect Dis. 1992;11:217-223
77. Denny FW, Clyde WA, Jr. Acute lower respiratory tract infections in nonhospitalized children. J Pediatr. 1986;108:635-646
78. Davies HD. Prospective comparative study of viral, bacterial and atypical organisms identified in pneumonia and bronchiolitis in hospitalized Canadian infants. Pediatr Infect Dis J. 1996;15:371-375
79. O'Handley JG, Gray LD. The incidence of Mycoplasma pneumoniae pneumonia. J Am Board Fam Pract. 1997;10:425-429
80. Fernald GW, Collier AM, Clyde WA, Jr. Respiratory infections due to Mycoplasma pneumoniae in infants and children. Pediatrics. 1975;55:327-335
81. Marrie TJ. Mycoplasma pneumoniae pneumonia requiring hospitalization, with emphasis on infection in the elderly. Arch Intern Med. 1993;153:488-494
82. Becton DL, Friedman HS, Kurtzberg J, Chaffee S, Falletta JM, Kinney TR. Severe Mycoplasma pneumonia in three sisters with sickle cell disease. Pediatr Hematol Oncol. 1986;3:259-265
83. Solanki DL, Berdoff RL. Severe Mycoplasma pneumonia with pleural effusions in a patient with sickle cell-hemoglobin C(SC) disease. Case report and review of the literature. Am J Med. 1979;66:707-710
84. Cimolai N. Mycoplasma pneumoniae respiratory infection. Pediatr Rev. 1998;19:327-332
85. Kozliuk AS. Elektronno-mikroskopicheskoe issledovanie organov dykhaniia pri eksperimental'nom respiratornom mikoplazmoze. Arkh Patol. 1980;42:34-40
86. Rollins S, Colby T, Clayton F. Open lung biopsy in Mycoplasma pneumoniae pneumonia. Arch Pathol Lab Med. 1986;110:34-41
87. Sokolova IA, Vaughan AT, Khodarev NN. Mycoplasma infection can sensitize host cells to apoptosis through contribution of apoptotic-like endonuclease(s). Immunol Cell Biol. 1998;76:526-534
88. Opitz O, Pietsch K, Ehlers S, Jacobs E. Cytokine gene expression in immune mice reinfected with Mycoplasma pnemuoniae: the role of T cell subsets in aggravating the inflammatory response. Immunobiology. 1996;196:575-587
89. Razin S, Yogev D, Naot Y. Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev (Washington, DC). 1998;62:1094-1156
90. Aldrich TK, Dhuper SK, Patwa NS, et al. Pulmonary entrapment of sickle cells: the role of regional alveolar hypoxia. J Appl Physiol. 1996;80:531-539
91. Hebbel RP, Visser MR, Goodman JL, et al. Potentiated adherence of sickle erythrocytes to endothelium infected by virus. J Clin Invest. 1987;80:1503-1506
92. Smolinski PA, Offermann MK, Eckman JR, Wick TM. Double-stranded RNA induces sickle erythrocyte adherence to endothelium: a potential role for viral infection in vaso-occlusive pain episodes in sickle cell anemia. Blood. 1995;85:2945-2950
93. Kragsbjerg P, Jones I, Vikerfors T, Holmberg H, Diagnostic value of blood cytokine concentrations in acute pneumonia. Thorax. 1995;50:1253-1257
94. Hsieh CC, Tang RB, Tsai CH, Chen W. Serum interleukin-6 and tumor necrosis factor-α concentrations in children with Mycoplasma pneumonia. J Microbiol Immunol Infect. 2001;34:109-112
95. Kragsbjerg P, Vikerfors T, Holmberg H. Cytokine responses in patients with pneumonia caused by Chlamydia or Mycoplasma. Respiration. 1998;65:299-303
96. Suga M, Ando M, Nishikawa H, Araki S. Adenosine deaminase activity and free IL-2 receptor levels in serum from patients with Mycoplasma pneumonia. Jpn J Med. 1991;30:108-112
97. Koh YY, Park Y, Lee HJ, Kim CK. Levels of interleukin-2, interferon-γ, and interleukin-4 in bronchoalveolar lavage fluid from patients with Mycoplasma pneumonia: implication of tendency toward increased immunoglobulin E production. Pediatrics. 2001;107(3). Available at: www.pediatrics.org/cgi/content/full/107/3/e39
98. Tsunekawa H, Takagi E, Kishimoto H, Shimokata K. Depressed cellular immunity in Mycoplasma pneumoniae pneumonia. Eur J Respir Dis. 1987;70:293-299
99. Overturf GD. Infections and immunizations of children with sickle cell disease. Adv Pediatr Infect Dis. 1999;14:191-218
100. Taylor SC, Shacks SJ, Mitchell RA. In vitro lymphocyte blastogenic responses and cytokine production in sickle cell disease patients with acute pneumonia. Pediatr Infect Dis J. 1996;15:340-344
101. Daian CM, Wolff AH, Bielory L. The role of atypical organisms in asthma. Allergy Asthma Proc. 2000;21:107-111
102. Sabato AR, Martin AJ, Marmion BP, Kok TW, Cooper DM. Mycoplasma pneumoniae: acute illness, antibiotics, and subsequent pulmonary function. Arch Dis Child. 1984;59:1034-1037
103. Mok JY, Waugh PR, Simpson H. Mycoplasma pneumonia infection. A follow-up study of 50 children with respiratory illness. Arch Dis Child. 1979;54:506-511
104. Ford MJ, Telfer Brunton WA, Millar J, Stewart C, Critchley JA. Mycoplasma pneumonia: failure of erythromycin therapy. Scott Med J. 1980;25:126-128
105. McCracken GH, Jr. Current status of antibiotic treatment for Mycoplasma pneumoniae infections. Pediatr Infect Dis. 1986;5:167-171
106. Niitu Y, Hasegawa S, Suetake T, Kubota H, Komatsu S, Horikawa M. Resistance of Mycoplasma pneumoniae to erythromycin and other antibiotics. J Pediatr. 1970;76:438-443
107. Shames JM, George RB, Holliday WB, Rasch JR, Mogabgab WJ. Comparison of antibiotics in the treatment of Mycoplasmal pneumonia. Arch Intern Med. 1970;125:680-684
108. Smith DB, Friedewald WT, Chanock RM. Shedding of Mycoplasma pneumoniae after tetracyline and erythromycin therapy. N Engl J Med. 1967;276:1172-1175
109. Esposito S, Blasi F, Arosio C, et al. Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing. Eur Respir J. 2000;16:1142-1146
110. Renaudin H, Bebear C. Comparative in vitro activity of azithromycin, clarithromycin, erythromycin and lomefloxacin against Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum. Eur J Clin Microbiol Infect Dis. 1990;9:838-841
111. Marc E, Chaussain M, Moulin F, et al. Reduced lung diffusion capacity after Mycoplasma pneumoniae pneumonia. Pediatr Infect Dis J. 2000;19:706-710
112. American Academy of Pediatrics, Committee on Infectious Diseases. Red Book 2000: Report of the Committee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000
113. Bebear CM, Renaudin H, Charron A, Gruson D, Lefrancois M, Bebear C. In vitro activity of trovafloxacin compared to those of five antimicrobials against Mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob Agents Chemother. 2000;44:2557-2560
114. Cohen MA, Huband MD, In-vitro susceptibilities of Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum to clinafloxacin, PD 131628, ciprofloxacin and comparator drugs. J Antimicrob Chemother. 1997;40:308-309
115. Duffy LB, Crabb D, Searcey K, Kempf MC. Comparative potency of gemifloxacin, new quinolones, macrolides, tetracycline and clindamycin against Mycoplasma spp. J Antimicrob Chemother. 2000;45(Suppl 1):29-33
116. File TM, Jr, Schlemmer B, Garau J, Cupo M, Young C. The 049 Clinical Study G. Efficacy and safety of gemifloxacin in the treatment of community-acquired pneumonia: a randomized, double-blind comparison with trovafloxacin. J Antimicrob Chemother. 2001;48:67-74
117. Kenny GE, Cartwright FD. Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob Agents Chemother. 2001;45:2604-2608
118. Gucuyener K, Simsek F, Yilmaz O, Serdaroglu A. Methyl-prednisolone in neurologic complications of Mycoplasma pneumonia. Indian J Pediatr. 2000;67:467-469
119. Smith R, Eviatar L. Neurologic manifestations of Mycoplasma pneumoniae infections: diverse spectrum of diseases. A report of six cases and review of the literature. Clin Pediatr (Phila). 2000;39:195-201
120. Lyon GM, Alspaugh JA, Meredith FT, et al. Mycoplasma hominis pneumonia complicating bilateral lung transplantation: case report and review of the literature. Chest. 1997;112:1428-1432
121. Madoff S, Hooper DC. Nongenitourinary infections caused by Mycoplasma hominis in adults. Rev Infect Dis. 1988;10:602-613
122. McMahon DK, Dummer JS, Pasculle AW, Cassell G. Extragenital Mycoplasma hominis infections in adults. Am J Med. 1990;89:275-281
123. Mufson MA. Mycoplasma hominis: a review of its role as a respiratory tract pathogen of humans. Sex Transm Dis. 1983;10(Suppl 4):335-340
124. Norton R. Mycoplasma hominis pneumonia. Med J Aust. 1993;158:361-362
125. Rylander M, Hallander HO. In vitro comparison of the activity of doxycycline, tetracycline, erythromycin and a new macrolide, CP 62993, against Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum. Scand J Infect Dis Suppl. 1988;53:12-17
126. Cummings MC, McCormack WM. Increase in resistance of Mycoplasma hominis to tetracyclines. Antimicrob Agents Chemother. 1990;34:2297-2299
127. Kenny GE, Cartwright FD. Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to new glycylcyclines in comparison with those to older tetracyclines. Antimicrob Agents Chemother. 1994;38:2628-2632
128. Kenny GE, Cartwright FD. Susceptibilities of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum to a new quinolone, trovafloxacin (CP-99, 219). Antimicrob Agents Chemother. 1996;40:1048-1049