An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension

British Journal of Pharmacology

Volumn 138, Issue 7, 2003, Pages 1313-1319

  Murray, Fiona ^a   MacLean, Margaret R ^a   Pyne, Nigel J ^a,b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Mitogen activated protein kinase; Phosphodiesterase gamma subunit; Pulmonary hypertension; Smooth muscle; Vasoconstrictor; Vasodilator

Indexed keywords

CYCLIC GMP PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE GAMMA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; MALE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; ANOXIA; BAROTRAUMA; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION, PULMONARY; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PULMONARY ARTERY; RATS;

EID: 0038415860     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705190     Document Type: Article

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