Effects of light fractionation and different fluence rates on photodynamic therapy with 5-aminolaevulinic acid in vivo

British Journal of Cancer

Volumn 88, Issue 9, 2003, Pages 1462-1469

  Babilas, P ^a   Schacht, V ^a,b   Liebsch, G ^a,c   Wolfbeis, O S ^a   Landthaler, M ^a   Szeimies, R M ^a   Abels, C ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BIOCAM GmbH   (Germany)

Author keywords

Amelanotic melanoma; Microcirculation; Oxygen; Protoporphyrin IX; Tumour

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

AMELANOTIC MELANOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CANCER REGRESSION; CONTROLLED STUDY; HAMSTER; LIGHT INTENSITY; MALE; MICROCIRCULATION; NONHUMAN; OXYGEN TENSION; PHOTODYNAMIC THERAPY; PHOTOLUMINESCENCE; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; SKINFOLD; TUMOR VOLUME;

AMINOLEVULINIC ACID; ANIMALS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, RADIATION; LIGHT; MELANOMA, EXPERIMENTAL; MESOCRICETUS; OXYGEN CONSUMPTION; PHOTOCHEMOTHERAPY; TIME FACTORS;

EID: 0038413636     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600910     Document Type: Article

References (53)

1. Abels C, Fritsch C, Bolsen K, Szelmies RM, Ruzicka T, Goerz G, Goetz AE(1997a) Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo. J Photochem Photobiol B 40: 76-83
2. Abels C, Heil P, Dellian M, Kuhnle GE, Baumgartner R, Goetz AE (1994) In vivo kinetics and spectra of 5-aminolaevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster. Br J Cancer 70: 826-833
3. Abels C, Szeimies RM, Steinbach P, Richert C, Goetz AE (1997b) Targeting of the tumor microcirculation by photodynamic therapy with a synthetic porphycene. J Photochem Photobiol B 40: 305-312
4. Ackermann G, Abels C, Baumler W, Langer S, Landthaler M, Lang EW, Szeimies RM (1998) Simulations on the selectivity of 5-aminolaevulinic acid-induced fluorescence in vivo. J Photochem Photobiol B 47: 121-128
5. 2 of the pig retina as measured with phosphorescence imaging. Surv Ophthalmol 42 (Suppl 1): S118-S126
6. Busch TM, Hahn SM, Evans SM, Koch CJ (2000) Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxia marker EF3 [2-(2-nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide]. Cancer Res 60: 2636-2642
7. Castellani A, Pace GP, Concioli M (1963) Photodynamic effect of haematoporphyrin on blood microcirculation. J Pathol Bacteriol 86: 99-103
8. Curnow A, Haller JC, Bown SG (2000) Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon. Comparison of continuous and fractionated light regimes. J Photochem Photobiol B 58: 149-155
9. de Bruijn HS, van der Veen N, Robinson DJ, Star WM (1999) Improvement of systemic 5-aminolevulinic acid-based photodynamic therapy in vivo using light fractionation with a 75-minute interval. Cancer Res 59: 901-904
10. Dellian M, Abels C, Kuhnle GE, Goetz AE (1995) Effects of photodynamic therapy on leucocyte-endothelium interaction: differences between normal and tumour tissue. Br J Cancer 72: 1125-1130
11. Dellian M, Helmlinger G, Yuan F, Jain RK (1996) Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. Br J Cancer 74: 1206-1215
12. Djavaheri-Mergny M, Marsac C, Maziere C, Santus R, Michel L, Dubertret L, Maziere JC (2001) UV-A irradiation induces a decrease in the mitochondrial respiratory activity of human NCTC 2544 keratinocytes. Free Radic Res 34: 583-594
13. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J, Peng Q (1998) Photodynamic therapy. J Natl Cancer Inst 90: 889-905
14. Edwards SR, Shanley BC, Reynoldson JA (1984) Neuropharmacology of delta-aminolaevulinic acid - I. Effect of acute administration in rodents. Neuropharmacology 23: 477-481
15. Endrich B, Asaishi K, Gotz A, Messmer K (1980) Technical report - a new chamber technique for microvascular studies in unanesthetized hamsters. Res Exp Med 177: 125-134
16. Fortner JG, Mahy AG, Schrodt GR (1961) Transplantable tumors of the Syrian (Golden) Hamsters. I. Tumors of the alimentary tract, endocrine glands and melanomas. Cancer Res 21: 161-198
17. Fritsch C, Batz J, Bolsen K, Schulte KW, Zumdick M, Ruzicka T, Goerz G (1997) Ex vivo application of delta-aminolevulinic acid induces high and specific porphyrin levels in human skin tumors: possible basis for selective photodynamic therapy. Photochem Photobiol 66: 114-118
18. Gibson SL, VanDerMeid KR, Murant RS, Raubertas RF, Hilf R (1990) Effects of various photoradiation regimens on the antitumor efficacy of photodynamic therapy for R3230AC mammary carcinomas. Cancer Res 50: 7236-7241
19. Grant WE, Hopper C, MacRobert AJ, Speight PM, Bown SG (1993) Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid. Lancet 342: 147-148
20. Hartmann P, Ziegler W, Lubbers DW (1997) Fluorescence lifetime imaging of the skin PO2 supply. Instrumentation and results. Adv Exp Med Biol 428: 605-611
21. Hua Z, Gibson SL, Foster TH, Hilf R (1995) Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitiser for photodynamic therapy in vivo. Cancer Res 55: 1723-1731
22. Iinuma S, Schomacker KT, Wagnieres G, Rajadhyaksha M, Bamberg M, Momma T, Hasan T (1999) In vivo fluence rate and fractionation effects on tumor response and photobleaching: photodynamic therapy with two photosensitisers in an orthotopic rat tumor model. Cancer Res 59: 6164-6170
23. Kriegmair M, Stepp H, Steinbach P, Lumper W, Ehsan A, Stepp HG, Rick K, Knuchel R, Baumgartner R, Hofstetter A (1995) Fluorescence cystoscopy following intravesical instillation of 5-aminolevulinic acid: a new procedure with high sensitivity for detection of hardly visible urothelial neoplasias. Urol Int 55: 190-196
24. Langer S, Abels C, Botzlar A, Pahernik S, Rick K, Szeimies RM, Goetz AE (1999) Active and higher intracellular uptake of 5-aminolevulinic acid in tumors may be inhibited by glycine. J Invest Dermatol 112: 723-728
25. Liebsch G, Klimant I, Frank B, Holst G, Wolfbeis OS (2000) Luminescence lifetime imaging of oxygen pH and carbon dioxide distribution using optical sensors. Appl Spectrosc 54: 548
26. Liebsch G, Klimant I, Krause C, Wolfbeis OS (2001) Fluorescent imaging of pH with optical sensors using time domain dual lifetime referencing. Anal Chem 73: 4354-4363
27. Livingston RB, Carter SK (1982) Experimental design and clinical trials: clinical perspectives. In Principles of Cancer Treatment, Carter SK, Glatstein SK, Livingston RB (eds). New York: McGraw-Hill
28. Lord E, Paoni S (2001) Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival. Radiat Res 155: 360-368
29. McIlroy BW, Curnow A, Buonaccorsi G, Scott MA, Bown SG, MacRobert AJ (1998) Spatial measurement of oxygen levels during photodynamic therapy using time-resolved optical spectroscopy. J Photochem Photobiol B 43: 47-55
30. Messmann H, Mlkvy P, Buonaccorsi G, Davies CL, MacRobert AJ, Bown SG (1995) Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies. Br J Cancer 72: 589-594
31. Mlkvy P, Messmann H, Regula J, Conio M, Pauer M, Millson CE, MacRobert AJ, Bown SG (1995) Sensitization and photodynamic therapy (PDT) of gastrointestinal tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX). A pilot study. Neoplasma 42: 109-113
32. Niedre M, Patterson MS, Wilson BC (2002) Direct near-infrared luminescence detection of singlet oxygen generated by photodynamic therapy in cells in vitro and tissues in vivo. Photochem Photobiol 75: 382-391
33. Nozue M, Lee I, Manning JM, Manning LR, Jain RK (1996) Oxygenation in tumors by modified hemoglobins. J Surg Oncol 62: 109-114
34. Pass HI (1993) Photodynamic therapy in oncology: mechanisms and clinical use. J Natl Cancer Inst 85: 443-456
35. Peng Q, Warloe T, Berg K, Moan J, Kongshaug M, Giercksky KE, Nesland JM (1997) 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges. Cancer 79: 2282-2308
36. 2 dynamics during photodynamic therapy with verteporfin. Photochem Photobiol 74: 700-706
37. Ribbert H (1904) Über das Gefäßsystem und die Heilbarkeit der Geschwülste. Dtsch Med Wochensch 29: 113-115
38. Rittenhouse-Diakun K, Van Leengoed H, Morgan J, Hryhorenko E, Paszkiewicz G, Whitaker JE, Oseroff AR (1995) The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA). Photochem Photobiol 61: 523-528
39. Robinson DJ, de Bruijn HS, de Wolf WJ, Sterenborg HJ, Star WM (2000) Topical 5-aminolevulinic acid-photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect. Photochem Photobiol 72: 794-802
40. Schacht V, Becker K, Landthaler M, Szeimies RM, Abels C (2001) Apoptosis and leucocyte-endothelium interactions contribue to the delayed effects of cryotherapy on solid tumors in vivo. Arch Dermatol Res 294: 341-348
41. Sitnik TM, Henderson BW (1998) The effect of fluence rate on tumor and normal tissue responses to photodynamic therapy. Photochem Photobiol 67: 462-466
42. Szeimies RM, Abels C, Fritsch C, Karrer S, Steinbach P, Baumler W, Goerz G, Goetz AE, Landthaler M (1995) Wavelength dependency of photodynamic effects after sensitization with 5-aminolevulinic acid in vitro and in vivo. J Invest Dermatol 105: 672-677
43. Szeimies RM, Sassy T, Landthaler M (1994) Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem Photobiol 59: 73-76
44. Tomayko MM, Reynolds CP (1989) Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 24: 148-154
45. Tsutsui H, MacRobert AJ, Curnow A, Rogowska A, Buonaccorsi G, Kato H, Bown SG (2002) Optimisation of illumination for photodynamic therapy with mTHPC on normal colon and a transplantable tumour in rats. Lasers Med Sci 17: 101-109
46. van Hillegersberg R, Kort WJ, Wilson JH (1994) Current status of photodynamic therapy in oncology. Drugs 48: 510-527
47. Vaupel P (1977) Hypoxia in neoplastic tissue. Microvasc Res 13: 399-408
48. Vaupel P (1994) Blood Flow, Oxygenation, Tissue pH Distribution, and Bioenergetic Status of Tumors, p 23. Berlin, Germany: Ernst Schering Research Foundation
49. Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465
50. Vaupel PW, Frinak S, Bicher HI (1981) Heterogeneous oxygen partial pressure and pH distribution in C3 H mouse mammary adenocarcinoma. Cancer Res 41: 2008-2013
51. Weiss N, Delius M, Gambihler S, Dirschedl P, Goetz A, Brendel W (1990) Influence of the shock wave application mode on the growth of A-Mel 3 and SSK2 tumors in vivo. Ultrasound Med Biol 16: 595-605
52. Williams WJE (1990) Hematology, 4th edn. New York: McGraw-Hill
53. Workman P, Balmain A, Hickman JA, McNally NJ, Rohas AM, Mitchison NA, Pierrepoint CG, Raymond R, Rowlatt C, Stephens TC et al (1988) UKCCCR guidelines for the welfare of animals in experimental neoplasia. Lab Anim 22: 195-201