Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children

American Journal of Hematology

Volumn 73, Issue 2, 2003, Pages 71-80

  Paredes Aguilera, Rogelio ^a   Romero Guzman, Lina ^a   Lopez Santiago, Norma ^a   Trejo, Rosa Arana ^b  

^a INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

^b HOSPITAL GENERAL DE MÉXICO   (Mexico)

Author keywords

AMKL; AML; Immunophenotype; Incidence

Indexed keywords

HEMOGLOBIN;

ACUTE LEUKEMIA; ACUTE MEGAKARYOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW EXAMINATION; CHILD; CHILDHOOD LEUKEMIA; CLINICAL FEATURE; FEMALE; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN DETERMINATION; HEPATOMEGALY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INFANT; KARYOTYPE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MYELOFIBROSIS; PRIORITY JOURNAL; SPLENOMEGALY;

BIOPSY; CHILD; CHILD, PRESCHOOL; CYTOGENETIC ANALYSIS; FEMALE; HUMANS; IMMUNOPHENOTYPING; INCIDENCE; INFANT; KARYOTYPING; LEUKEMIA, MEGAKARYOCYTIC, ACUTE; MALE; PROSPECTIVE STUDIES;

EID: 0038393121     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.10320     Document Type: Article

References (70)

1. Breton-Gorius J, Reyes F, Duhamel G, Najman A, Gorin NC. Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase. Blood 1978;51:45-60.
2. Bennett JM, Catovsky D, Daniel M-T, et al. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Ann Intern Med 1985; 103:460-462.
3. Koike T, Aoki S, Maruyama S, et al. Cell surface phenotyping of megakaryoblasts. Blood 1987;69:957-960.
4. Koike T, Urushiyama M, Narita M, et al. Target cell of leukemic transformation in acute megakaryoblastic leukemia. Am J Hematol 1990;34:252-258.
5. Von Boros J, Korenyi A. Über einen Fall von akuter Megakaryoblastenleukämie, zugleich einige Bemerkungen zum Problem der akuter Leukämie. Z Klin Med 1931;118:697-718.
6. Bennett JM, Catovsky D, Daniel M-T, et al. Proposals for the classification of the acute leukaemias. Br J Haematol 1976;33:451-458.
7. Breton-Gorius J, Guichard J. Ultrastructural localization of peroxidase activity in human platelets and megakaryocytes. Am J Pathol 1972; 66:277-286.
8. Breton-Gorius J, Dreyfus B, Sultan C, Basch A, d'Oliveira JG. Identification of circulating micromegakaryocytes in a case of refractory anemia: an electron microscopic cytochemical study. Blood 1972;40: 453-463.
9. Breton-Gorius J, Daniel MT, Flandrin G, Kinet-Denoel G. Fine structure and peroxidase activity of circulating micromegakaryoblasts and platelets in a case of acute myelofibrosis. Br J Haematol 1973;25:331-339.
10. Breton-Gorius J, Vanhaeke D, Pryzwansky KB, et al. Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase. Br J Haematol 1984;58:447-458.
11. Innes DJ, Mills SE, Walker GK. Megakaryocytic leukemia. Am J Clin Pathol 1982;77:107-110.
12. Koike T. Megakaryoblastic leukemia: the characterization and identification of megakaryoblasts. Blood 1984;64:683-692.
13. Huang MJ, Li ChY, Nichols WL, Young JH, Katzmann JA. Acute leukemia with megakaryocytic differentiation: a study of 12 cases identified immunocytochemically. Blood 1984;64:427-439.
14. Carroll A, Civin C, Schneider N, et al. The t(1;22)(p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group study. Blood 1991;78:748-752.
15. Lion T, Haas OA, Harbott J, et al. The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children. Blood 1992;79:3325-3330.
16. Creutzig U, Harbott J, Sperling C, et al. Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87. Blood 1995;86:3097-3108.
17. Slordahl SH, Gustafsson G, Jonmudsson G, et al. Down's syndrome (DS) and myelogenous leukemia (AML). A population-based study in the five Nordic countries. Med Pediatr Oncol 1992;20:439 (abstract).
18. Hirt A, Luethy AR, Mueller B, Gucler E, Wagner HP. Acute megakaryoblastic leukemia in children identified by immunological marker studies. Am J Pediatr Hematol/Oncol 1990;12:27-33.
19. Martínez-Climent JA, Tortajada JF, Menor CE, Miralles AV, Castel SV. Leucemia megacarioblástica aguda en la infancia. An Esp Pediatr 1993;38:545-549.
20. Ribeiro RC, Oliveira MAP, Fairclough D, et al. Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases. Leuk Lymphoma 1993;10:299-306.
21. Athale UH, Razzouk BI, Raimondi CS, et al. Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. Blood 2001;97:3727-3732.
22. Flandrin G, Daniel MT, Valensi F, Schaison G, Breton-Gorius J. Leucemie aigue a megakaryoblastes. Etude clinique et morphologique de 11 observations. Act Hematol 1977;11:200-211.
23. Chan WC, Brynes RK, Kim TH, Verras A, Schnick, Green RJ, Ragab AH. Acute megakaryoblastic leukemia in early childhood. Blood 1983;62:92-98.
24. Cairney AEL, McKenna R, Arthur DC, Nesbit ME, Woods WG. Acute megakaryoblastic leukemia in children. Br J Haematol 1986;63:541-554.
25. Sariban E, Oliver C, Corash L, Cossman J, et al. Acute megakaryoblastic leukaemia in childhood. Cancer 1984;54:1423-1428.
26. Lu G, Altman AJ, Benn PA. Review of the cytogenetic changes in acute megakaryoblastic leukemia: one disease or several? Cancer Genet Cytogenet 1993;67:81-89.
27. Tallman MS, Neuberg D, Bennett JM, et al. Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. Blood 2000;96:2405-2411.
28. Ruiz-Argüelles GJ, Marín-López A, Lobato-Mendizabal E, Ruiz-Argüelles A, Nichols WL, Katzman JA. Acute megakaryoblastic leukaemia: a prospective study of its identification and treatment. Br J Haematol 1986;62:55-63.
29. Bloomfield CD, Brunning RD. FAB M7: acute megakaryoblastic leukemia. Beyond morphology. Ann Intern Med 1985;103:450-452.
30. Borowitz MJ, Guenther KL, Shultz KE, Stelzer T. Immunophenotyping of acute leukemia by flow cytometric analysis. Am J Clin Pathol 1993;100:534-540.
31. Betz SA, Foucar K, Head DR, Chen IM, Willman L. False-positive flow cytometric platelet glycoprotein IIb/IIIa expression in myeloid leukemias secondary to platelet adherence to blast. Blood 1992;79: 2399-2403.
32. Mitelman F. ISCN 1995. An international system for human cytogenetic nomenclature. Basel, Switzerland: Karger; 1995.
33. Windebank KP, Tefferi A, Smithson WA, et al. Acute megakaryocytic leukemia (M7) in Children. Mayo Clin Proc 1989;64:1339-1351.
34. Lie SO, Jonmundsson G, Mellander L, et al. A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants and children with Down's syndrome. Br J Haematol 1996;94:82-88.
35. Zipursky A. Editorial. The treatment of children with acute megakaryoblastic leukemia who have Down syndrome. J Pediatr Hematol Oncol 1996;18:10-12.
36. Dastugue N, Lafage-Pochitaloff M, Pages M-P, et al. Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). Blood 2002;100:618-626.
37. Bernstein J, Dastugue N, Haas OA, et al. Nineteen cases of the t(1;22)(p13;q13) acute megakaryoblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group. Leukemia 2000;14:216-218.
38. Arana-Trejo RM, Paredes-Aguilera R, Nieto S, Kofman SA. A t(1;22)(p13;q13) in four children with acute megakaryoblastic leukemia (M7), two with Down syndrome. Cancer Genet Cytogenet 2000; 120:160-162.
39. Mercher T, Busson-Le CM, Monni R, et al. Involvement of a human gene related to the Drosophilia spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A 2001;98:5776-5779.
40. Ma Z, Morris SW, Valentine V, Li M, et al. Fusion of two novel genes, RBM-15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 2001;28(3):220-221.
41. Rahmani Z, Blouin J-L, Creau-Goldberg N, et al. Critical role of the D21S55 region on the chromosome 21 in the pathogenesis of Down syndrome. Proc Nad Acad Sci U S A 1989;86:5958-5962.
42. Appelbaum FR, Gilliland DG, Tallman MS. The biology and treatment of acute myeloid leukemia. Education Program Book. Washington, DC: American Society of Hematology; 1998. p 15-43.
43. Dreyfus F, Picard F, Gisselbrecht S, et al. Ets-1 and Ets-2 protooncogene expression in human leukemia cells and cell lines. Nouv Rev Fr Hematol 1989;30:243-246.
44. Levaltier X, Reman O, Boutard JC, et al. Leucémie aiguë mégacaryoblastique. Arch Fr Pediatr 1991;48:563-566.
45. Nichols CR, Hoffman R, Einhorn LH, Williams S, Weeler LA, Garnick MB. Hematologic malignancies associated with primary mediastinal germ cell tumors. Ann Intern Med 1985;102:603-609.
46. st edition. Philadelphia: J.B. Lippincott Company; 1989. p 19-37.
47. Groopman JE. The pathogenesis of myelofibrosis in myeloproliferative disorders (editorial). Ann Intern Med 1980;92:857-858.
48. Kepner N, Lipton A. A mitogenic factor for transformed fibroblasts from human platelets. Cancer Res 1981;41:430-432.
49. Castro M H, Rabellino EM, Yen A, Nachman RL, et al. Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts. Blood 1981;57:781-787.
50. Breton-Gorius J, Bizet M, Reyes F, et al. Myelofibrosis and acute megakaryoblastic leukemia in a child: topographic relationship between fibroblasts and megakaryocytes with an α granule defect. Leuk Res 1982;6:97-110.
51. Terui T, Niitsu Y, Mahara K, et al. The production of transforming growth factor in acute megakaryoblastic leukemia and its possible implications and myelofibrosis. Blood 1990;75:1540-1548.
52. Sunami S, Fuse A, Simizu B, et al. The c-sis gene expression in cells from a patient with acute megakaryoblastic leukemia and Down's syndrome. Blood 1987;70:368-371.
53. Mehta AB, Baughan AS, Catovsky JM, Goldman SA. Reversal of marrow fibrosis in acute megakaryoblastic leukaemia after remission-induction and consolidation chemotherapy followed by bone marrow transplantation. Br J Haematol 1983;53:445-449.
54. Wolf JL, Spruce WE, Bearman RM, et al. Reversal of acute ("malignant") myelosclerosis by allogenic bone marrow transplantation. Blood 1982;59:191-194.
55. Dharmasena F, Wickham N, McHughn PJ, et al. Osteolytic tumors in acute megakaryoblastic leukemia. Cancer 1986;58:2273-2277.
56. Slavc I, Urban C, Haas OA, Kroisel PM, Köeller U, et al. Acute megakaryocytic leukemia in children. Cancer 1991;68:2266-2272.
57. Peterson BA, Levine EG. Uncommon subtypes of acute nonlymphocytic leukemia: clinical features and management of FAB M5, M6 and M7. Semin Oncol 1987;14:425-434.
58. Pui CH, Rivera G, Mirro J. Acute megakaryoblastic leukemia. Arch Pathol Lab Med 1985;109:1033-1035.
59. Penchansky L, Suzanne R, Taylor MD, et al. Three infants with acute megakaryoblastic leukemia simulating metastatic tumor. Cancer 1989; 64:1366-1371.
60. Ashfaq R, Weinberg AG, Argyle CA. Acute megakaryoblastic leukemia simulating carcinoma. Am J Clin Pathol 1992;98:55-60.
61. Kitagawa M, Yoshida S, Ishige I, et al. Immunolocalization of platelet-derived growth factor, transforming growth factor-β, and fibronectin in acute megakaryoblastic leukemia manifesting tumor formation. Hum Pathol 1994;25:723-726.
62. Vinci G, Tabillo A, Deschamps JF, et al. Immunological study of in vitro maturation of human megacaryocytes. Br J Haematol 1984;56: 589-605.
63. Erber WN, Breton-Gorius J, Villeval JL, et al. Detection of cells of megakaryocyte lineage in haematological malignancies by immunoalkaline phosphatase-labelling cell smears with a panel of monoclonal antibodies. Br J Haematol 1987;65:87-94.
64. +: improved criteria for diagnosis of AML-M7? Leukemia 1997;11:830-834.
65. Rabelino EM, Levene RB, Leung L, et al. Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes. J Exp Med 1981;154:88-100.
66. Pombo de Oliveira MS, Gregory C, Matutes E, et al. Cytochemical profile of megakaryoblastic leukaemia: a study with cytochemical methods, monoclonal antibodies, and ultrastructural cytochemistry. J Clin Pathol 1987;40:663-669.
67. Marshall T, Schreeder MD, Prchal JT, et al. An acute myeloproliferative disorder characterized by myelofibrosis and blast cells that express phenotypic properties associated with multiple hematopoietic lineages. Am J Clin Pathol 1985;83:114-121.
68. Cuneo A, Mecucci C, Kerim S, et al. Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients. Blood 1989;74:1781-1790.
69. Slordahl HS, Smeland EB, Holte H, et al. Leukemic blasts with markers of four cell lineages in Down's syndrome ("megakaryoblastic leukemia"). Med Pediatr Oncol 1993;21:254-258.
70. San Miguel JF, González MC, Cañizo E, et al. Leukemias with megakaryoblastic involvement: clinical, hematologic and immunologic characteristics. Blood 1988;72:402-407.