Effect of estradiol on chemokine receptor CXCR2 expression in rats: Implications for atherosclerosis

Acta Pharmacologica Sinica

Volumn 24, Issue 7, 2003, Pages 670-674+725

  Lei, Zhu Bin ^a   Fu, Xu Jie ^a   Lu, Zhao Tong ^a   Wang, Bao Cheng ^a   Liu, Xian Liang ^a   You, Nai Zhen ^a  

^a JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

17 estradiol; Chemokine receptors; Flow cytometry; Monocytes; Reverse transcriptase polymerase chain reaction

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR2; CHOLESTEROL; ESTRADIOL; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATTENUATION; CHOLESTEROL INTAKE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; FLOW CYTOMETRY; IN VIVO STUDY; MONOCYTE; NONHUMAN; OVARIECTOMY; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; STATISTICAL SIGNIFICANCE;

ANIMALS; ARTERIOSCLEROSIS; CELL SEPARATION; DIET, ATHEROGENIC; ESTRADIOL; FEMALE; GENE EXPRESSION; LEUKOCYTES, MONONUCLEAR; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-8B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0038391492     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999; 340: 1801-11.
2. Gerrity RG, Goss JA, Soby L. Control of monocyte recruitment of chemotactic factor(s) in lesion-prone areas of swine aorta. Arteriosclerosis 1985; 5: 55-66.
3. Nathan L, Pervin S, Singh R, Ricks J, Rosenfeld M, Chaudhuri G. Estradiol reduces monocyte adherence to vascular endothelium in vivo. Circulation 1996; 94 Suppl I: I-151.
4. Chuntharapai A, Lee J, Hebert CA, Kim KJ. Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes. J Immunol 1994; 153: 5682-8.
5. Bishayi B, Samanta AK. Identification and characterization of specific receptor for interleukin-8 from the surface of human monocytes. Scand J Immunol 1996; 43: 531-6.
6. Lei ZB, Wen CY, Xu J, Li X, Qing L, Wei M. OxLDL upregulates growth-regulated oncogene α functionally expression in human endothelial cells. Chin Med J 2001; 114: 1240-4.
7. Lei ZB, Li XY, Wang BC, Yang YF, You NZ, Sun J. Regulation of growth-regulated oncogene α expression by estrogen in human endothelial cells. Acta Pharmacol Sin 2001; 22: 1003-6.
8. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999; 398: 718-23.
9. Boisvert WA, Santiago R, Curtiss LK, Terkeltaub RA. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 1998; 101: 353-63.
10. Lea CK, Sarma U, Flanagan AM. Macrophage colony stimulating-factor transcripts are differentially regulated in rat bone-marrow by gender hormones. Endocrinology 1999; 140: 273-9.
11. Jones BM, Nicholson JK, Holman RC, Hubbard M. Comparison of monocyte separation methods using flow cytometric analysis. J Immunol Methods 1989; 125: 41-7.
12. Lei ZB, Zhang Z, Jing Q, Qin YW, Pei G, Cao BZ, et al. Oxidized LDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase activation. Cardiovasc Res 2002; 53: 524-32.
13. Huo Y, Weber C, Forlow SB, Sperandio M, Thatte J, Mack M, et al. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J Clin Invest 2001; 108: 1307-14.
14. Sack MN, Rader DJ, Cannon RO III. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 1994; 343: 269-70.