Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing

Circulation Research

Volumn 92, Issue 11, 2003, Pages 1247-1253

  Stepanovic, Vesna ^a   Awad, Ola ^a   Jiao, Chunhua ^a   Dunnwald, Martine ^b   Schatteman, Gina C ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Angiogenesis; Bone marrow; Stem cells; Type 2 diabetes; Wound healing

Indexed keywords

LEPTIN RECEPTOR; CELL SURFACE RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; HISTOLOGY; KNOCKOUT MOUSE; MALE; MORPHOMETRICS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; STEM CELL; STEM CELL TRANSPLANTATION; TISSUE REPAIR; VASCULARIZATION; WOUND HEALING; ANIMAL; C57BL MOUSE; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; GENETICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INFLAMMATION; INJECTION; INJURY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SKIN;

ANIMALS; DIABETES MELLITUS, TYPE 2; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; INFLAMMATION; INJECTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, CELL SURFACE; SKIN; SKIN PHYSIOLOGY; WOUND HEALING;

EID: 0038380277     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000074906.98021.55     Document Type: Article

References (21)

1. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-967.
2. Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A, Fujita Y, Kothari S, Mohle R, Sauvage LR, Moore MA, Storb RF, Hammond WP. Evidence for circulating bone marrow-derived endothelial cells. Blood. 1998;92:362-367.
3. + cells identifies a population of functional endothelial precursors. Blood. 2000;95:952-958.
4. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;105:369-377.
5. Issarachai S, Priestley GV, Nakamoto B, Papayannopoulou T. Cells with hemopoietic potential residing in muscle are itinerant bone marrowderived cells. Exp Hematol. 2002;30:366-373.
6. McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci USA. 2002;99:1341-1346.
7. Schatteman GC, Hanlon HD, Jiao C, Dodds SG, Christy BA. Bloodderived angioblasts accelerate blood-flow restoration in diabetic mice. J Clin Invest. 2000;106:571-578.
8. Swift ME, Kleinman HK, DiPietro LA. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest. 1999;79:1479-1487.
9. Servold SA. Growth factor impact on wound healing. Clin Podiatr Med Surg. 1991;8:937-953.
10. Colville-Nash PR, Willoughby DA. Growth factors in angiogenesis: current interest and therapeutic potential. Mol Med Today. 1997;3:14-23.
11. Ansel JC, Armstrong CA, Song I, Quinlan KL, Olerud JE, Caughman SW, Bunnett NW. Interactions of the skin and nervous system. J Invest Dermatol Symp Proc. 1997;2:23-26.
12. Adler AI, Boyko EJ, Ahroni JH, Smith DG. Lower-extremity amputation in diabetes: the independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers. Diabetes Care. 1999;22:1029-1035.
13. + cells accelerate vascularization of diabetic skin wounds. J Vasc Res. In press.
14. Tsuboi R, Shi CM, Rifkin DB, Ogawa H. A wound healing model using healing-impaired diabetic mice. J Dermatol. 1992;19:673-675.
15. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol. 1990;136:1235-1246.
16. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996;183:1797-1806.
17. Luna L. Manual of Histologic Staining Methods of the AFIP. New York, NY: McGraw-Hill; 1968.
18. Hinkle DE, Wiersma W, Jurs SG. Applied Statistics for the Behavioral Sciences. 3rd ed. Boston, Mass: Houghton Mifflin Co; 1994.
19. Tsuboi R, Rifkin DB. Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice. J Exp Med. 1990;172:245-251.
20. Knighton DR, Hunt TK, Thakral KK, Goodson WH 3rd. Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis. Ann Surg. 1982;196:379-388.
21. Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb Z, Banda MJ. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science. 1983;221:1283-1285.