Ethyl acetate soluble fraction of Cnidium officinale MAKINO inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolyccharide-treated rat hippocampal slice cultures and microglia cells

Journal Pharmacological Sciences

Volumn 92, Issue 1, 2003, Pages 74-78

  Kim, Jeong Min ^a   Son, Dongwook ^a   Lee, Pyeongjae ^a   Lee, Kang Jin ^a   Kim, Hocheol ^a   Kim, Sun Yeou ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Cnidium officinale MAKINO; Hippocampal slice; Nitric oxide

Indexed keywords

ACETIC ACID DERIVATIVE; ACETIC ACID ETHYL ESTER; CNIDIUM OFFICINALE EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MAKINO EXTRACT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT EXTRACT; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL DEATH; CELL LINE; CELL SURVIVAL; CHEMISTRY; CNIDIUM; CNIDIUM OFFICIALE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; HIPPOCAMPUS; IN VITRO STUDY; INHIBITION KINETICS; MEDICINAL PLANT; MICROGLIA; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PLANT ROOT; RAT; REGULATORY MECHANISM; SOLUBILITY; TISSUE CULTURE; WESTERN BLOTTING;

CNIDIUM OFFICINALE;

EID: 0038380196     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.92.74     Document Type: Article

References (13)

1. McGeer PL, McGeer EG. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neorodegenerative diseases. Brain Res Rev. 1995;21:195-218.
2. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanisms of nitric oxide mediated neurotoxicity in primary brain cultures. J Neurosci. 1993;13:2651-2661.
3. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE. Microglia cell cytotoxicity of oligodentrocytes is mediated through nitric oxide. J Immunol. 1993;151:2132-2141.
4. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 1997;20:132-139.
5. Radi R, Beakmann JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem. 1991;266:4244-4250.
6. Chou TC, Yang SP, Pei D. Amlodipine inhibits pro-inflammatory cytokines and free radical production and inducible nitric oxide synthase expression in lipopolysaccharide/interferon-gamma-stimulated cultured vascular smooth muscle cells. Jpn J Pharmacol. 2002;89:157-163.
7. Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): Prospects for drug discovery and development. Trends Pharmacol Sci. 1999;20:191-196.
8. Lee BG, Kim SH, Zee OP, et al. Suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by two β-carboline alkaloids extracted from Melia azedarach. Eur J Pharmacol. 2000;406:301-309.
9. Noraberg J, Kristensen BW, Zimmer J. Markers for neuronal degeneration in organotypic slice cultures. Brain Res Protoc. 1999;3:278-299.
10. Macklis JD, Madison RD. Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological statue; A fluorescence scale of membrane integrity. J Neurosci Methods. 1990;31:43-46.
11. Chao CC, Hu S. Tumor necrosis factor alpha potentiates glutamate neurotoxicity in human fetal brain cultures. Dev Neurosci. 1994;16:172-179.
12. Prosperi C, Scali C, Pepeu G, Casamenti F. NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain. Jpn J Pharmacol. 2001;86:230-235.
13. Vincent SR. Nitric oxide: A radical neurotransmitters in the central nerve system. Prog Neurobiol. 1994;42:129-160.