Polyglutamine neurodegeneration: Minding your Ps and Qs

Nature Medicine

Volumn 9, Issue 7, 2003, Pages 825-826

  Paulson, Henry ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CALBINDIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLYGLUTAMINE; PROTEIN; PROTEIN 14 3 3; UNCLASSIFIED DRUG;

DISEASE ASSOCIATION; HUMAN; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PURKINJE CELL; SHORT SURVEY; SPINOCEREBELLAR DEGENERATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 14-3-3 PROTEINS; ANIMALS; HUMANS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; NUCLEAR PROTEINS; PEPTIDES; PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPINOCEREBELLAR ATAXIAS; TYROSINE 3-MONOOXYGENASE;

EID: 0038379383     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0703-825     Document Type: Short Survey

References (13)

1. Taylor, J.P., Hardy, J. & Fischbeck, K.H. Toxic proteins in neurodegenerative disease. Science 296, 1991-1995 (2002).
2. Emamian, E.S. et al. Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron 38, 375-387 (2003).
3. Chen, H.K. et al. Interaction of akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell 113, 457-468 (2003).
4. Orr, H.T. & Zoghbi, H.Y. SCA1 molecular genetics: a history of a 13 year collaboration against glutamines. Hum. Mol. Genet. 10, 2307-2311 (2001).
5. Fernandez-Funez, P. et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408, 101-106 (2000).
6. Bonini, N.M. Chaperoning brain degeneration. Proc. Natl. Acad. Sci. USA 99 (suppl. 4), 16407-16411 (2002).
7. Hsu, A.L., Murphy, C.T. & Kenyon, C. Regulation of aging and age-related disease by DAF-16 and heatshock factor. Science 300, 1142-1145(2003).
8. Waelter, S. et al. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol. Biol. Cell 12, 1393-1407 (2001).
9. Humbert, S. et al. The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev. Cell 2, 831-837 (2002).
10. Kawamoto, Y., Akiguchi, I., Nakamura, S. & Budka, H. Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy. Ann. Neurol. 52, 722-731 (2002).
11. Xu, J. et al. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 8, 600-606 (2002).
12. Hashiguchi, M., Sobue, K. & Paudel, H.K. 14-3-3zeta is an effector of tau protein phosphorylation. J. Biol. Chem. 275, 25247-25254 (2000).
13. Katsuno, M. et al. Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat. Med. 9, 768-773 (2003).