Interactions and consequences of the combined use of alcohol and cocaine: An update on cocaethylene;Interacciones y consecuencias del consumo combinado de alcohol y cocaína: Una actualización sobre el cocaetileno

Adicciones

Volumn 15, Issue 2, 2003, Pages 159-164

  Pastor, D Raul ^a   José Llopis, Juan ^a   Abel Baquero, D ^b  

^a UNIVERSITAT JAUME I   (Spain)

^b NONE

Author keywords

Abuse; Alcohol; Cocaethylene; Cocaine; Toxicity

Indexed keywords

ALCOHOL; COCAINE; HOMOCOCAINE;

COMPULSION; DRUG BLOOD LEVEL; HUMAN; METABOLISM; MULTIPLE DRUG ABUSE; REVIEW; SELF CONTROL; SOCIAL PROBLEM; TOXICOKINETICS;

EID: 0038378234     PISSN: 02144840     EISSN: None     Source Type: Journal    
DOI: 10.20882/adicciones.439     Document Type: Review

References (36)

1. Andrews, P. (1997). Cocaethylene toxicity. J Addict Dis 16: 75-84.
2. Baumann, M.H.; Horowitz, J.M.; Kristal, M.B. and Torres, G. (1998). Effects of cocaethylene on dopamine and serotonin synthesis in Long-Evans and Sprague Dawley brains. Brain Research 804: 316-319.
3. Brzezinski, M.R.; Abraham, T.L.; Stone, C.L.; Dean, R.A. and Bosron, W.F. (1994). Purification and characterization of a human liver cocaine carbolylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem Pharmacol 48: 1747-1755.
4. Calafat, A.; Juan, M.; Becoña, E.; Fernández, C.; Gil, E. y Llopis, J.J. (2001). Vida social de la cocaína. Monografía cocaína. Adicciones. Vol 13, suplemento 2, pp 61-104.
5. Dean, R.A.; Christian, C.D.; Sample, R.H.B. and Bosron W.F. (1991). Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine. FASEB J 5: 2735-2739.
6. Dean, R.A.; Bosron, W.F.; Zachman, F.M. and Brzezinski, M.R. (1997.) Effects of ethanol on cocaine metabolism and disposition in the rat. NIDA Research monograph 173: 35-47.
7. Farré, M.; de la Torre, R.; Llorente, M.; Lamas, X.; Ugena, B.; Segura, J. and Camf, J. (1993). Alcohol and cocaine interactions in humans. J Pharmacol Exp Ther 266: 1364-1373.
8. Hayase, T.; Abiru, H.; Yamamoto, Y.; Yamamoto, K. and Fukui, Y. (1998). Brain-Endorphin inmumoreactivity as an index of cocaine and combined cocaine-ethanol toxicities. Pharmacology Biochemistry and Behavior 60: 263-270.
9. Hearn, W.L.; Flynn, D.D.; Hime, G.W.; Rose, S.; Confino, J.C; Mantero-Atienza, E.; Wetli, C.W. and Mash, D.C. (1991). Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem 56: 698-701.
10. Horger, B.A.; Taylor, J.R.; Elsworth, J.D.; Jatlow, P.I.; and Roth, R.H. (1996). Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Res 733: 133-137.
11. Iyer, R.N.; Nobiletti, J.B.; Jatlow, P.I. and Bradberry, C.W. (1995). Cocaine and cocaethylene: effects on extracellular dopamine in the primate. Psychopharmacology 120: 105-110.
12. Jover, R.; Ponsoda, X.; Gómez-Lechón, M.J.; Herrero, C.; del Pino, J. and Castell J.V. (1991). Potentiaton of cocaine hepatotoxicity by ethanol in human hepatocytes. Toxicol Appl Pharmacol 107: 526-534.
13. Jatlow, P.; McCance, E.F.; Bradberry, C.W.; Elsworth, J.D.; Taylor, J.R. and Roth, R.H. (1996). Alcohol plus cocaine: the whole is more than the sum of its parts. Ther Drug Monit 18: 460-464.
14. Landry, M.J. (1992). An overview of cocaethylene, an alcohol-derived, psychoactive, cocaine metabolite. J Psychoactive Drugs 24: 273-276.
15. Lindholm, S.; Rosin, A.; Dahlin, I.; Georgieva, J. and Franck, J. (2001). Ethanol administation potentiates cocaine-induced dopamine levels in the rat nucleus accumbens. Brain Research 915: 176-184.
16. McCance-Katz, E.F.; Price, L.H.; McDougle, C.J.; Marek, G.J.; Kosten, T.R. and Jatlow, P. (1991). Cocaethylene formation following sequential administration of cocaine and ethanol to humans: Pharmacological, phsiological, and behavioral studies. Soc Neurosci Abs 17: 890.
17. O.E.D.T. (2001) Informe anual sobre el problema de la drogodependencia en la Unión Europea 2001. Oficina de publicaciones oficiales de las Comunidades Europeas. Luxemburgo.
18. Pan, W.J. and Hedaya, M.A. (1999). Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. J Pharma Sci 88(12): 1266-1274.
19. Perez-Reyes, M. and Jeffcoat, A.R. (1992). Ethanol/cocaine and coaethylene concentrations and their relationship to subjetive and cardiovascular effects. Life Sci 51: 553-563.
20. Perez-Reyes, M. (1994). The order of drug administration: its effects on the interactio between cocaiene and ethanol. Life Sci 55: 541-550.
21. Pirozhkov, S. V.; Watson, R. R. and Chen, G. (1993). Ethanol enhances inmunosuppression induced by cocaine. Alcohol. Alcohol Suppl 2: 75-82.
22. P.N.D. (2001). Informe sobre la situación de la Cocaína en España. Abril 2001. Delegación del Gobierno para el Plan Nacional sobre Drogas. PNSD/Internet. Ministerio de Interior.
23. Prinssen, E.P.; Kleven, M.S. and Koek, W. (1996). Repeated administration of cocaethylene induces context-dependent sensitization to its locomotor effects. Psychopharmacology 124: 300-305.
24. Qiu, Z.; and Morgan, J.P. (1993). Differential effects of cocaine and cocaethylene on intracellular Ca2+ and myocardial contraction in cardiac myocytes. Br. J. Pharmacol Jun 109: 293-298.
25. Raven, M. A.; Necessary, B.D.; Danluck, D.A. and Ettenberg, A. (2000) Comparison of the reinforcing and anxiogenic effects of intravenous cocaine and cocaethylene. Exp Clin Psychopharmacol 8: 117-124.
26. Roberts, S.M.; Roth, L.; Harbison, R.D. and James, R.C. (1992). Cocaethylene hepatotoxicity in mice. Biochem Pharmacol May 8;43: 1989-1995.
27. Rose, S.; Hearn, W.L.; Hime, G.W.; Wetli, C.V.; Ruttenber, A.J.; and Mash, D.C. (1990). Cocaine and cocaethylene concentrations in human post mortem cerebral cortex. Neurosci Abs 16: 11-17.
28. Signs, S.A.; Dickey-White, H.I.; Vanek, V.W.; Perch, S.; Schechter, M.D.; and Kulics, A.T. (1996). The formation of cocaethylene and clinical presentation of ED patients testing positive for the use of cocaine and ethanol. Am J Emerg Med Nov 14: 665-670.
29. Singer, L.T.; Arendt, R.; Minnes, S.; Farkas, K. and Salvator, A. (2000). Neurobehavioral outcomes of cocaine-exposed infants. Neurotoxicologycal Terotology 22: 653-666.
30. Schechter, M.D. (1995). Cocaethylene produces conditioned place preference in rats. Pharmacol Biochem Behav 51: 549-552.
31. Schechter, M.D. and Meehan, S.M. (1995).The lethal effects of ethanol and cocaine and their combinations in mice: implications for cocaethylene formation. Pharmacol Biochem Behav 52: 245-248.
32. Spealman, R.D.; Madras, B.K. and Bergman, J. (1989). Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior. J Pharmacol Exp Ther 252: 142-149.
33. Torres, G; Horowitz, J.M.; Lee, S. and Rivier, C. (1996). Cocaethylene stimulates the secretion of ACTH and corticosterone and the transcriprional activation of hypothalamic NGFI-B. Brain Res Mol Brain 43: 225-232.
34. Vanek, V.W.; Dickey-White, H. I.; Schechter, M.D.; Buss, T. and Kulics, A.T. (1996). Concurrent use of cocaine and alcohol by patients treated in the emergency deparment. Ann Emerg Med, Nov 28: 508-514.
35. Wilson, L.D.; Jeromin, J.; Garvey, L. and Dorbandt, A. (2001). Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse. Acad Emerg Med 8: 211-222.
36. Xu, Y. Q.; Crumb, W. J. and Clarkson, C. W. (1994). Cocaethylene a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels. J Pharmacol Exp Ther 27: 319-325.