Heat shock preconditioning modulates proliferation and apoptosis after superficial injury in isolated guinea pig gastric mucosa via an eicosanoid and protein synthesis-dependent mechanism

APMIS

Volumn 111, Issue 4, 2003, Pages 497-506

  Oksala, Niku K J ^a,c   Oksala, Anni ^a   Paavonen, Timo ^d   Alhava, Esko ^a   Paimela, Hannu ^b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b JORVI HOSPITAL   (Finland)

^c KANTA HÄME CENTRAL HOSPITAL   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Arachidonic acid; Bax; Cycloheximide hyperthermia; Indomethacin; Injury; Mib 1; Proliferation; Quercetin; Restitution

Indexed keywords

ANTIGEN; ARACHIDONIC ACID; ETICYCLIDINE; HEAT SHOCK PROTEIN; ICOSANOID; INDOMETACIN; LIPOXYGENASE; MIB 1 PROLIFERATION ANTIGEN; PROSTAGLANDIN SYNTHASE; PROTEIN BAX; QUERCETIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY TEMPERATURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; GUINEA PIG; HEAT SHOCK; IMMUNOHISTOCHEMISTRY; METABOLISM; NONHUMAN; PERFUSION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STOMACH EPITHELIUM; STOMACH INJURY; STOMACH MUCOSA;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; BCL-2-ASSOCIATED X PROTEIN; CELL DIVISION; CYCLOHEXIMIDE; ENZYME INHIBITORS; GASTRIC MUCOSA; GUINEA PIGS; HEAT-SHOCK RESPONSE; HYPERTHERMIA, INDUCED; IMMUNOHISTOCHEMISTRY; INDOMETHACIN; KI-67 ANTIGEN; PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUERCETIN; WOUND HEALING;

EID: 0038377911     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0463.2003.1110408.x     Document Type: Article

References (44)

1. Podolsky DK. Innate mechanisms of mucosal defense and repair: the best offense is a good defense. Am J Physiol 1999;277:G495-9.
2. Critchlow J, Magee D, Ito S, Takeuchi K, Silen W. Requirements for restitution of the surface epithelium of frog stomach after mucosal injury. Gastroenterology 1985;88:237-49.
3. Paimela H, Goddard PJ, Carter K, Khakee R, McNeil PL, Ito S, Silen W. Restitution of frog gastric mucosa in vitro: effect of basic fibroblast growth factor. Gastroenterology 1993;104:1337-45.
4. Bhowmik A, Paimela H, Joutsi T, Alanko T, Paavonen T, Saksela O, Kivilaakso E. Induction of proliferation in isolated guinea pig gastric epithelium during restitution after superficial injury. Dig Dis Sci 1998;43:1507-12.
5. Benjamin IJ, McMillan ER. Stress (heat shock) proteins, molecular chaperones in cardiovascular biology and disease. Circ Res 1998;83:117-32.
6. Buchner J. Supervising the fold: functional principles of molecular chaperones. FASEB J 1996; 1:10-9.
7. Morimoto RI. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 1998;24:3788-96.
8. Jaattela M. Escaping cell death: survival proteins in cancer Exp Cell Res 1999;248:30-43.
9. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 2000;20:7146-59.
10. Hirakawa T, Rokutan K, Nikawa T, Kishi K. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 1996; 111:345-57.
11. Itoh YH, Noguchi R. Pre-treatment with mild whole-body heating prevents gastric ulcer induced by restraint and water-immersion stress in rats. Int J Hyperthermia 2000;2:183-91.
12. Oksala NKJ, PaimelaH, AlhavaE. Preconditioning hyperthermia inhibits restitution of isolated guinea pig gastric mucosa. Eur Surg Res 2002; 34:339-45.
13. Oksala NK, Paimela H, Alhava E. Heat-shock preconditioning affects restitution of isolated guinea pig gastric mucosa by an arachidonic acid and protein synthesis dependent mechanism. Scand J Gastroenterol 2002;37:1366-73.
14. Jurivich DA, Sistonen L, Sarge KD, Morimoto RI. Arachidonate is a potent modulator of human heat shock gene transcription. Proc Natl Acad Sci USA 1994;91:2280-4.
15. Fawzy AA, Vishwanath BS, Franson RC. Inhibition of human non-pancreatic phospholipases A2 by retinoids and flavonoids. Mechanism of actions. Agents Actions 1988;25:394-400.
16. Lindahl M, Tagesson C. Selective inhibition of group II phospholipase A2 by quercetin. Inflammation 1993;17:573-82.
17. Hirasawa N, Santini F, Beaven MA. Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules. J Immunol 1995;154:5391-402.
18. Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B. Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol 1991;9:1673-81.
19. Kim HP, Mani I, Iversen L, Ziboh VA. Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxy genase from guinea-pigs. Prostaglandins Leukot Essent Fatty Acids 1998;1:17-24.
20. Bossu E, Agliano AM, Desideri N, Sestili I, Porra R, Grandilone M, Quaglia MG. LTB4 as marker of 5-LO inhibitory activity of two new N-omega-ethoxycarbonyl-4-quinolones. J Pharm Biomed Anal 1999;34:539-48.
21. Kokoska ER, Smith GS, Deshpande Y, Wolff AB, Miller TB. Indomethacin increases susceptibility to injury in human gastric cells independent of PG synthesis inhibition. Am J Physiol 1998;275:G620-8.
22. Nollen EA, Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stresssensing 'heat shock' proteins. J Cell Sci 2002; 115:2809-16.
23. Calderwood SK, Bornstein B, Farnum EK, Stevenson MA. Heat shock stimulates the release of arachidonic acid and the synthesis of prostaglandins and leukotriene B4 in mammalian cells. J Cell Physiol 1989;2:325-33.
24. Shimakura S, Boland CR. Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. Cancer Res 1992;52:1744-9.
25. Han SI, Oh SY, Jeon WJ, Kim JM, Lee JH, Chung HY, Choi YH, Yoo MA, Kim HD, Kang HS. Mild heat shock induces cyclin D1 synthesis through multiple Ras signal pathways. FEBS Lett 2002;515:141-5.
26. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182:311-22.
27. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993;74:609-19.
28. Antonsson B. Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion. Cell Tissue Res 2001;306:347-61.
29. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 1997;139:1281-92.
30. Rosse T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 1998;391:496-9.
31. Zhou XM, Wong BC, Fan XM, Zhang HB, Lin MC, Kung HF, Fan DM, Lam SK. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis 2001;22:1393-7.
32. Konturek PC, Brzozowski T, Konturek SJ, Pajdo R, Konturek JE, Kwiecien S, Taut A, Hahn EG. Apoptosis in gastric mucosa with stress-induced gastric ulcers. J Physiol Pharmacol 1999;50:211-25.
33. Woo CH, You HJ, Cho SH, Eom YW, Chun JS, Yoo YJ, Kim JH. Leukotriene B4 stimulates rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. J Biol Chem 2002;277:8572-8.
34. Neu B, Herrmuth H, Ernst F, Vaupel W, Reindl W, Hutzler P, Atkinson MJ, Classen M, Schepp W. Differential expression of CD95, Bcl-2, and Bax in rat gastric chief and parietal cells. Microsc Res Tech 2001;53:377-88.
35. Tang DG, Chen YQ, Honn KV. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci 1996; 93:5241-6.
36. Uribe A, Rubio C, Johansson C. Alternating proliferative capacity in the rat gastrointestinal mucosa. Effects of E2 prostaglandins and indomethacin. Scand J Gastroenterol 1988;23:163-70.
37. Goodlad RA, Madgwick AJ, Moffatt MR, Levin S, Allen JL, Wright NA. The effects of the prostaglandin analogue, misoprostol, on cell proliferation and cell migration in the canine stomach. Digestion 46 1990;Suppl 2:182-7.
38. Michiels C, De Leener F, Arnould T, Dieu M, Remacle J. Hypoxia stimulates human, endothelial cells to release smooth muscle cell mitogens: role of prostaglandins and bFGF. Exp Cell Res 1994;213:43-54.
39. Uribe A, Alam M, Winell-Kapraali M. Indomethacin inhibits cell proliferation and increases cell losses in rat gastrointestinal epithelium. Dig Dis Sci 1995;40:2490-4.
40. Uribe A, Garberg L. Prostaglandin E2-induced hyperplasia of the rat antral epithelium is followed by a secondary inhibition of the mitotic activity. Prostaglandins 1990;40:1-11.
41. Uribe A. Indomethacin inhibits cell proliferation in the oxyntic epithelium of the rat. Prostaglandins 1993;45:15-26.
42. Uribe A, Alam M, Soderman C. Cell kinetic events in early indomethacin-induced gastrointestinal ulcerations in the rat. Eur J Gastroenterol Hepatol 1997;9:267-73.
43. Levi S, Goodlad RA, Lee CY, Stamp G, Walport M J, Wright NA, Hodgson HJ. Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 1990;336:840-3.
44. Stockton RA, Jacobson RS. Modulation of cellsubstrate adhesion by arachidonic acid: lipoxygenase regulates cell spreading and ERK1/2-inducible cyclooxygenase regulates cell migration in NIH-3T3 fibroblasts. Mol Biol Cell 2001;12:1937-56.