The role of pretraining on skilled forelimb use in an animal model of Huntington's disease

Cell Transplantation

Volumn 12, Issue 3, 2003, Pages 257-264

  Fricker Gates, Rosemary A ^a   Smith, R ^a   Muhith, J ^a   Dunnett, S B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Motor functions; Quinolinic acid; Skilled forelimb use; Striatal lesion

Indexed keywords

QUINOLINIC ACID;

ANALYSIS OF VARIANCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FORELIMB; HISTOLOGY; HUNTINGTON CHOREA; MOTOR ACTIVITY; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ANIMALIA;

EID: 0038363448     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000003108746812     Document Type: Conference Paper

References (24)

1. Abrous, D. N.; Dunnett, S. B. Skilled paw reaching in rats: The staircase test. Neurosci. Prot. 3:1-11; 1994.
2. Dunnett, S. B.; Nathwani, F.; Björklund, A. The integration and function of striatal grafts. In: Björklund, A.; Dunnett, S. B., eds. Functional neural transplantation II: Novel cell therapies for CNS disorders. New York: Elsevier Science; 2000:345-380.
3. Emerich, D. F.; Lindner, M. D.; Winn, S. R.; Chen, E. Y.; Frydel, B. R.; Kordower, J. H. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J. Neurosci. 16:5168-5181; 1996.
4. Fisher, R. S.; Shiota, C.; Levine, M. S.; Hull, C. D.; Buchwald, N. A. Subcortical crossed axonal projections to the caudate nucleus of the cat: A double-labelling study. Neurosci. Lett. 51:25-30; 1984.
5. Fricker, R. A.; Annett, L. E.; Torres, E. M.; Dunnett, S. B. The locus of a striatal ibotenic acid lesion affects the direction of drug-induced rotation and skilled forelimb use. Brain Res. Bull. 41:409-416; 1996.
6. Fricker, R. A.; Torres, E. M.; Hume, S. P.; Myers, R.; Opacka-Juffry, J.; Ashworth, S.; Dunnett, S. B. The effects of donor stage on the survival and function of embryonic striatal grafts. II. Correlation between positron emission tomography and reaching behaviour. Neuroscience 79:711-722; 1997.
7. Frim, D. M.; Uhler, T. A.; Short, M. P.; Ezzedine, Z. D.; Klagsbrun, M.; Breakefield, X. O.; Isacson, O. Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions. Neuroreport 4:367-370; 1993.
8. Gerfen, C. R.; Staines, W. A.; Arbuthnott, G. W.; Fibiger, H. C. Crossed connections of the substantia nigra in the rat. J. Comp. Neurol. 207:283-303; 1982.
9. Herrera-Marschitz, M.; Meana, J. J.; Hökfelt, T.; You, Z. B.; Morino, P.; Brodin, E.; Ungerstedt, U. Cholecystokinin is released from a crossed corticostriatal pathway. Neuroreport 3:905-908; 1992.
10. Ilinsky, I. A.; Kultas-Ilinsky, K.; Rosina, A.; Haddy, M. Quantitative evaluation of crossed and uncrossed projections from basal ganglia and cerebellum to the cat thalamus. Neuroscience 21:207-227; 1987.
11. Jeyasingham, R. A.; Baird, A.; Meldrum, A.; Dunnett, S. B. Differential effects of unilateral striatal and nigrostriatal lesions on grip strength, skilled paw reaching and drug-induced rotation in the rat. Brain Res. Bull. 55:541-548; 2001.
12. Marston, H. M.; Faber, E. S. L.; Crawford, J. H.; Butcher, S. P.; Sharkey, J. Behavioural assessment of endothelin-1 induced middle cerebral artery occlusion in the rat. Neuroreport 6:1067-1071; 1995.
13. Martinez-Serrano, A.; Björklund, A. Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. J. Neurosci. 16:4604-4616; 1996.
14. Miklyaeva, E. I.; Castañeda, E.; Whishaw, I. Q. Skilled reaching deficits in unilateral dopamine-depleted rats: Impairments in movement and posture and compensatory adjustments. J. Neurosci. 14:7148-7158; 1994.
15. Montoya, C. P.; Astell, S.; Dunnett, S. B. Effects of nigral and striatal grafts on skilled forelimb use in the rat. Prog. Brain Res. 82:459-466; 1990.
16. Montoya, C. P.; Campbell-Hope, L. J.; Pemberton, K. D.; Dunnett, S. B. The staircase test: A measure of independent forelimb reaching and grasping abilities in rats. J. Neurosci. Methods 36:219-228; 1991.
17. Nakao, N.; Brundin, P. Effects of alpha-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid. Neuroscience 76:749-761; 1997.
18. Nakao, N.; Grasbon-Frodl, E. M.; Widner, H.; Brundin, P. DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease. Neuroscience 74:959-970; 1996.
19. Pérez-Navarro, E.; Arenas, E.; Reiriz, J.; Calvo, N.; Alberch, J. Glial cell line derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage. Neuroscience 75:345-352; 1996.
20. Pisa, M. Motor functions of the striatum in the rat: Critical role of the lateral region in tongue and forelimb reaching. Neuroscience 24:453-463; 1988.
21. Ungerstedt, U.; Arbuthnott, G. W. Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res. 24:485-493; 1970.
22. Watts, C.; Brasted, P. J.; Eagle, D. M.; Dunnett, S. B. Embryonic donor age and dissection influence striatal graft development and functional integration in a rodent model of Huntington's disease. Exp. Neurol. 163:85-97; 2000.
23. Whishaw, I. Q.; O'Connor, W. T.; Dunnett, S. B. The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat. Brain 109: 805-843; 1986.
24. Wilson, C. J. Morphology and synaptic connections of crossed corticostriatal neurons in the rat. J. Comp. Neurol. 263:567-580; 1987.