Cyclophosphamide induces dose- and time-dependent elevations in spleen norepinephrine levels of BALB/c mice

Neuroscience Letters

Volumn 344, Issue 2, 2003, Pages 117-121

  Karp, Jonathan D ^a   Szczytkowski, Jennifer L ^a  

^a RIDER UNIVERSITY   (United States)

Author keywords

Chemotherapy; Cyclophosphamide; Neuroimmunology; Norepinephrine; Spleen

Indexed keywords

CYCLOPHOSPHAMIDE; NORADRENALIN;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL INTERACTION; CONCENTRATION (PARAMETERS); DOSE CALCULATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; LOW DRUG DOSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; REVIEW; SPLEEN; SPLEEN SIZE; TIME;

EID: 0038356798     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00420-8     Document Type: Review

References (20)

1. Anderson D., Bishop J.B., Garner R.C., Ostrosky-Wegman P., Selby P.B. Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat. Res. 330:1995;115-181.
2. Bellinger D.L., Lorton D., Lubahn C., Felten D.L. Innervation of lymphoid organs - association of nerves with cells of the immune system and their implications in disease. Ader R., Felten D., Cohen N. 3rd Edition Psychoneuroimmunology. 2001;55-111 Academic Press, New York.
3. Callahan T.A., Moynihan J.A. Contrasting pattern of cytokines in antigen- versus mitogen-stimulated splenocyte cultures from chemically denervated mice. Brain Behav. Immun. 16:2002;764-773.
4. Carlson S.L., Felten D.L., Livnat S., Felten S.Y. Noradrenergic sympathetic innervation of the spleen: V. Acute drug-induced depletion of lymphocytes in the target fields of innervation results in redistribution of noradrenergic fibers but maintenance of compartmentation. J. Neurosci. Res. 18:1987;64-69.
5. Cottney J., Bruin J., Lewis A.J. Modulation of the immune system in the mouse. 1. Drug administration prior to antigen sensitization. Agents Actions. 10:1980;378-388.
6. Cottney J., Bruin J., Lewis A.J. Modulation of the immune system in the mouse. 2. Drug administration following antigen sensitization. Agents Actions. 10:1980;48-56.
7. Elenkov I.J., Wilder R.L., Chrousos G.P., Vizi E.S. The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol. Rev. 52:2000;595-638.
8. Exton M.S., Schult M., Donath S., Strubel T., Bode U., del Rey A., Westermann J., Schedlowski M. Conditioned immunosuppression makes subtherapeutic cyclosporin effective via splenic innervation. Am. J. Physiol. 276:1999;R1710-R1717.
9. Hori T., Katafuchi T., Take S., Shimizu N., Niijima A. The autonomic nervous system as a communication channel between the brain and the immune system. Neuroimmunomodulation. 2:1995;203-215.
10. Ishiyama N., Utsuyama M., Kitagawa M., Hirokawa K. Immunological enhancement with a low dose of cyclophosphamide in aged mice. Mech. Ageing Dev. 111:1999;1-12.
11. Karp J.D., Smith J., Hawk K. Restraint stress augments antibody production in cyclophosphamide-treated mice. Physiol. Behav. 70:2000;271-278.
12. Kohm A.P., Sanders V.M. Norepinephrine: a messenger from the brain to the immune system. Immunol. Today. 21:2000;539-542.
13. Ludeman S.M. The chemistry of the metabolites of cyclophosphamide. Curr. Pharm. Des. 5:1999;627-643.
14. Madden K.S., Felten D.L. Experimental basis for neural-immune interactions. Physiol. Rev. 75:1995;77-106.
15. Pelaez B., Campillo J.A., Lopez-Asenjo J.A., Subiza J.L. Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxide-dependent mechanism. J. Immunol. 166:2001;6608-6615.
16. Sanders V., Kasprowicz D., Kohm A., Swanson M. Neurotransmitter receptors on lymphocytes and other lymphoid cells. Ader R., Felten D., Cohen N. 3rd Edition Psychoneuroimmunology. 2001;161-198 Academic Press, New York.
17. Sanders V.M., Straub R.H. Norepinephrine, the beta-adrenergic receptor, and immunity. Brain Behav. Immun. 16:2002;290-332.
18. Singer N.G., McCune W.J. Update on immunosuppressive therapy. Curr. Opin. Rheumatol. 10:1998;169-173.
19. Wan W., Vriend C.Y., Wetmore L., Gartner J.G., Greenberg A.H., Nance D.M. The effects of stress on splenic immune function are mediated by the splenic nerve. Brain Res. Bull. 30:1993;101-105.
20. Zandvoort A., Lodewijk M.E., Klok P.A., Dammers P.M., Kroese F.G., Timens W. Slow recovery of follicular B cells and marginal zone B cells after chemotherapy: implications for humoral immunity. Clin. Exp. Immunol. 124:2001;172-179.