Effect of experimental renal failure and hypotonic hyponatremia on the pharmacodynamics of cefazolin-induced seizures in rats

Pharmaceutical Research

Volumn 20, Issue 6, 2003, Pages 937-942

  Nagata, Masashi ^a   Fujichika, Takuya ^a   Yasuhara, Masato ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cefazolin; Hyponatremia; Pharmacodynamics; Renal failure; Seizures

Indexed keywords

ARGIPRESSIN; CALCIUM; CEFAZOLIN; CEFPIROME; GLUCOSE; POTASSIUM; SODIUM ION; URANYL NITRATE; WATER;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG INFUSION; DRUG SENSITIVITY; DRUG TISSUE LEVEL; ELECTROLYTE BLOOD LEVEL; HYPONATREMIA; KIDNEY FAILURE; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; BRAIN; CEFAZOLIN; CEPHALOSPORINS; ELECTROLYTES; HYPONATREMIA; HYPOTONIC SOLUTIONS; INFUSIONS, INTRAVENOUS; KIDNEY FAILURE; MALE; RATS; RATS, WISTAR; SEIZURES;

EID: 0038353594     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023855723584     Document Type: Article

References (20)

1. T. P. Bechtel, R. L. Slaughter, and T. D. Moore. Seizures associated with high cerebrospinal fluid concentrations of cefazolin. Am. J. Hosp. Pharm. 37:271-273 (1980).
2. R. L. Yost, J. D. Lee, and J. P. O'Leary. Convulsions associated with sodium cefazolin: a case report. Am. Surg. 43:417-420 (1977).
3. M. Nishida, T. Matsubara, T. Murakawa, Y. Mine, and Y. Yokota. Cefazolin, a new semisynthetic cephalosporin antibiotic. III. Absorption, excretion and tissue distribution in parenteral administration. J. Antibiotics 23:184-194 (1970).
4. M. Nagata and M. Yasuhara. Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats. Biol. Pharm. Bull 24:1049-1052 (2001).
5. I. M. Ramzan and G. Levy. Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. J. Pharmacol. Exp. Ther. 240:584-588 (1987).
6. I. Ramzan and G. Levy. Kinetics of drug action in disease states XXXIII: Disparate effects of pentylenetetrazol in rats as a function of renal disease model and pharmacologic endpoint. J. Pharm. Sci. 78:142-145 (1989).
7. Y. Nakada, K. Yamamoto, J. Kawakami, Y. Sawada, and T. Iga. Effect of acute renal failure on neurotoxicity of cimetidine in rats. Pharm. Res. 12:1953-1957 (1995).
8. I. Ramzan. Theophylline neurotoxicity is unaffected by glycerol-induced renal failure. Pharmacol. Biochem. Behav. 37:583-585 (1990).
9. F. J. Gennari. Current concepts. Serum osmolality. Uses and limitations. N. Engl. J. Med. 310:102-105 (1984).
10. M. Danhof and G. Levy. Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex. J. Pharmacol. Exp. Ther. 229:44-50 (1984).
11. S. Hori, S. Kurioka, and M. Matsuda, and J. Shimada. Inhibitory effect of cephalosporins on γ-aminobutyric acid receptor binding in rat synaptic membranes. Antimicrob. Agents Chemother. 27: 650-651 (1985).
12. A. I. Arieff, F. Llach, and S. G. Massry. Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore) 55:121-129 (1976).
13. J. C. Ayus, R. K. Krothapalli, and D. L. Armstrong. Rapid correction of severe hyponatremia in the rat: histopathological changes in the brain. Am. J. Physiol. 248:F711-F719 (1985).
14. O. Arisaka, N. Shimura, A. Hosaka, Y. Nakayama, K. Kaneko, M. Maeda, and K. Yaubta. Water intoxication in asthma assessed by urinary arginine vasopressin. Eur. J. Pediatr. 148:167-169 (1988).
15. D. Milford and C. M. Taylor. Hyponatraemia and haemolytic uraemic syndrome. Lancet 25:439 (1989).
16. V. Vanapruks and K. Prapaitrakul. Water intoxication and hyponatraemic convulsions in neonates. Arch. Dis. Child. 64:734-744 (1989).
17. H. J. Adrogue and N. E. Madias. Hyponatremia. N. Engl. J. Med. 342:1581-1589 (2000).
18. J. Zhi and G. Levy. Kinetics of drug action in disease states. XXXVII. Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats. J. Pharmacol. Exp. Ther. 251:827-832 (1989).
19. A. Hoffman and G. Levy. Kinetics of drug action in disease states. XXXIX. Effect of orally administered activated charcoal on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline administered intravenously to rats with renal failure. Pharm. Res. 7:242-246 (1990).
20. P. P. De Deyn, R. D'Hooge, P. P. Van Bogaert, and B. Marescau. Endogenous guanidino compounds as uremic neurotoxins. Kidney Int. 59:S77-S83 (2001).