Anti-β2-glycoprotein I antibodies recognizing platelet factor 4-heparin complex in antiphospholipid syndrome in patient substantiated with mouse model

Journal of Molecular Recognition

Volumn 16, Issue 3, 2003, Pages 125-130

  Bourhim, Mustapha ^a   Darnige, Luc ^b   Legallais, Cécile ^c   Arvieux, Josiane ^d   Cevallos, Ramiro ^b   Pouplard, Claire ^e   Vijayalakshmi, Mookambeswaran A ^a  

^a UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^b Centre Hospitalier Compiegne   (France)

^c UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^d BREST UNIVERSITY HOSPITAL   (France)

^e SERVICE DE DERMATOLOGIE   (France)

Author keywords

2 glycoprotein I; Animal model; Anticardiolipin; Antiphospholipid antibodies; Antiphospholipid syndrome; Crossreactivity; Heparin; heparin induced thrombocytopenia; Platelet factor 4 heparin complex; Thrombocytopenia

Indexed keywords

ANIMALIA;

ANTIBODY; BETA2 GLYCOPROTEIN 1; GLYCOPROTEIN; HEPARIN; IMMUNOGLOBULIN M; LIPOSOME; THROMBOCYTE FACTOR 4;

ADULT; ANIMAL; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD; CROSS REACTION; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PATHOLOGY; PREGNANCY; THROMBOCYTE COUNT;

ADULT; ANIMALS; ANTIBODIES; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; CROSS REACTIONS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOPROTEINS; HEPARIN; HUMANS; IMMUNOGLOBULIN M; LIPOSOMES; MICE; PLATELET COUNT; PLATELET FACTOR 4; PREGNANCY;

EID: 0038350595     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmr.619     Document Type: Article

References (13)

1. 2-glycoprotein I as an antigen. J. Immunol. Meth. 143: 223-229.
2. 2 glycoprotein I autoantibodies and its relevance to anticardiotipin antibody quantitation. Thromb. Haemostas. 75: 725-730.
3. Blank M, Cohen J, Toder V, Shoenfeld Y. 1991. Induction of antiphospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anticardiolipin antibodies. Proc. Natl Acad. Sci. USA 88: 3069-3073.
4. Blank M, Cines DB, Arepally G, Eldor A, Afek A, Shoenfeld Y. 1997. Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in-vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin. Clin. Exp. Immunol. 108: 333-339.
5. Branch DW, Dudley DJ, Mitchell MD, Creightari KA, Abott JM, Hammond EH, Daynes RA. 1990. Immunoglobulin G fractions from patients with Antiphospholipid antibodies caused fetal death in Balb/c mice: a model for autoimmune fetal loss. Am. J. Obstet. Gynecol. 163: 210-216.
6. Kabat EA, Nickerson KG, Liao J, Grossbard L, Osserman EF, Glickman E, Chess L, Robbins JB, Schneerson R, Yang Y. 1986. A human monoclonal macroglobulin with specificity for alpha(2-8)-linked poly-N-acetyl neuraminic acid, the capsular polysaccharide of group meningococci and Escherichia coil K1, which crossreacts with polynucleotides and with denatured DNA. J. Exp. Med. 164: 642-654.
7. 2-glycoprotein I induces charge-dependent crossreactive antibodies that bind anionic phospholipids and have similar reactivity as autoimmune antiphospholipid antibodies. J. Immunol. 155: 958-66.
8. Lasne D, Saffroy R, Bachelot C, Vincenot A, Rendu F, Papo T, Aiach M, Piette JC. 1997. Tests for heparin-induced thrombocytopenia in primary antiphospholipid syndrome. Br. J. Haematol. 4: 939.
9. Martinuzzo ME, Forastiero RR, Adamczuk Y, Pombo G, Carreras LO. 1999. Antiplatelet Factor4-heparin antibodies in patients with antiphospholipid antibodies. Thromb. Res. 95: 271-279.
10. 2-glycoprotein I and human immunoglobulin G antiphospholipid antibodies. Circulation 94: 1746-1751.
11. Pouplard C, Amiral J, Borg JY, Vissac AM, Delahousse B, Gruel Y. 1997. Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium. Br. J. Haematol. 99(2): 273-280.
12. Pouplard C, Vissac AM, Amiral J et al. 1999. Instantia-HPIA, a new rapid test for the diagnosis of heparin-induced thrombocytopenia. Thromb. Haemost. 82(suppl.): 740 (Abstract 2340).
13. Shibata S, Harpel PC, Gharavi A, Rand J, Fillit H. 1994. Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes. Blood 83: 2532-2540.