PS-501, fermented papaya preparation, improves scopolamine-induced amnesia in mice

Research Communications in Pharmacology and Toxicology

Volumn 6, Issue 3-4, 2001, Pages 197-204

  Imao, Katsuki ^a,c   Kameyama, Tsutomu ^b   Ukai, Makoto ^c  

^a SAIDO Co   (Japan)

^b Japan Inst of Psychopharmacology   (Japan)

^c MEIJO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; PS 501; SCOPOLAMINE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG EFFECT; FERMENTED PRODUCT; LONG TERM MEMORY; MALE; MOUSE; NONHUMAN; PAPAYA; PASSIVE AVOIDANCE; SHORT TERM MEMORY;

ANIMALIA; CARICA PAPAYA;

EID: 0038349967     PISSN: 10871101     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Bruce, K.A., Li, Y., Lovell, M., Kraemer, P., Gary, D., Brown, R., Markesbery, W.R., Mattson, M.P.(1998). 4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats. J. Neuropathol. Expr. Neurol. 57: 257-267.
2. Carney, J.M., Strake-Reed, P.E., Olliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F. and Floyd, R.A. (1991). Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitron. Proc. Nat. Acad. Sci. U.S.A. 88: 3633-3636.
3. Gabbita, S., Lovell, M., Markesbery, W. (1998). Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem 71: 2034-2040.
4. Harman, D. (1956). Aging: A theory based on free radical and radiation chemistry, J. Gerontol. 11: 298-300.
5. Harman, D. (1992). Free radical theory of aging: History, In I. Emerit and B. Chance. (Eds.), Free Radicals and Aging, Ed. Birkhauser Verlag, Switzerland, PP.1-10.
6. Imao, K., Wang, H., Komatsu, M., and Hiramatsu, M. (1998). Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide level and superoxide dismutase activity in iron-induced epileptic foci of rats. Biochem. and Molec. Biol. Int. 45: 11-23.
7. Imao, K., Komatsu, M., Wang, H., and Hiramatsu, M., 1999. Inhibitory effect of fermented papaya preparation on oxidative DNA damage and tissue injury in the brain formed during iron-induced epileptiogenesis in rats. J. Brain Sci. 25: 71-77.
8. Kameyama, T., and Nabeshima, T. (1986). Step-down-type passive avoidance- and escape-learning method suitability for experimental amnesia models. J. Pharmacol. Methods 16: 39-52.
9. Maneesub, Y., Sanvarinda, Y., Govitrapong, P. (1993). Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E. Neurochem. Int. 22: 487-491.
10. Markesbery, W.R. (1997). Oxidative stress hypothesis in Alzheimer's disease. Free Rad. Biol. Med. 23: 134-147.
11. Packer, L., Hiramatsu, M., and Yoshikawa, T. (1996). Free Radicals in Brain Physiology and Disorders, Academic Press, San Diego.
12. Sarter, M., Bodewitz, G., and Stephens, D.N. (1998). Attenuation of scopolamine-induced impairment of spontaneous alteration behavior by antagonist but not inverse agonist and agnoist β-cabolines. Psychopharmacology 94: 491-495.
13. Quisumbing, E. (1978). Medicinal Plants of the Philippines. Katha Publishing, Manila
14. Ukai, M., Itoh, J., Kobayashi, T., Shinkai, N., and Kameyama, T. (1997). Effect of the κ-opioid dynorphin A(1-13) on learning and memory in mice. Behav. Brain Res. 83: 169-172.
15. Wang, H., Imao, K., Komatsu, M., and Hiramatsu, M. (2000). Antioxidant property of fermented papaya preparation. Res. Comm. Biochem. Cell. Molec. Biol. 4: 141-150.