The correlation between patient characteristics and expectations of benefit from phase I clinical trials

Cancer

Volumn 98, Issue 1, 2003, Pages 166-175

  Weinfurt, Kevin P ^a,i   Castel, Liana D ^a   Li, Yun ^a   Sulmasy, Daniel P ^b,c   Balshem, Andrew M ^d   Benson III, Al B ^e   Burnett, Caroline B ^f,g   Gaskin, Darrell J ^h   Marshall, John L ^g   Slater, Elyse F ^d   Schulman, Kevin A ^a   Meropol, Neal J ^d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ST VINCENT S HOSPITAL MANHATTAN   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f GEORGETOWN UNIVERSITY   (United States)

^g GEORGETOWN UNIVERSITY   (United States)

^h JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

Clinical trials; Decision making; Informed consent; Phase I; Quality of life

Indexed keywords

ADULT; AGED; ARTICLE; CANCER; CANCER THERAPY; DECISION MAKING; EXPECTATION; EXPERIMENTAL DESIGN; FEMALE; HEALTH SURVEY; HUMAN; INFORMED CONSENT; MAJOR CLINICAL STUDY; MALE; PATIENT ATTITUDE; PATIENT EDUCATION; PERSONALITY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; QUALITY OF LIFE; RELIGION;

ADULT; AGED; CLINICAL TRIALS, PHASE I; DECISION MAKING; FEMALE; HUMANS; INFORMED CONSENT; MALE; MIDDLE AGED; NEOPLASMS; PATIENT PARTICIPATION; PATIENT SELECTION; PATIENTS; PERCEPTION; QUALITY OF LIFE; TRUTH DISCLOSURE;

EID: 0038339691     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.11483     Document Type: Article

References (25)

1. Beauchamp TL, Childress JF. Principles of biomedical ethics, 5th edition. New York: Oxford University Press, 2001.
2. Cheng JD, Hitt J, Koczwara B, et al. Impact of quality of life on patient expectations regarding Phase I clinical trials. J Clin Oncol. 2000;18:421-428.
3. Siminoff LA, Fetting JH, Abeloff MD. Doctor-patient communication about breast cancer adjuvant therapy. J Clin Oncol. 1989;7:1192-1200.
4. Lee SJ, Fairclough D, Antin JH, Weeks JC. Discrepancies between patient and physician estimates for the success of stem cell transplantation. JAMA. 2001;285:1034-1038.
5. Daugherty CK. Impact of therapeutic research on informed consent and the ethics of clinical trials: a medical oncology perspective. J Clin Oncol. 1999;17:1601-1617.
6. Meropol NJ., Schulman KA, Weinfurt K, et al. Discordant perceptions of patients and their physicians regarding Phase I trials [abstract]. Proc Am Soc Clin Oncol. 2002;21:245a.
7. Daugherty C, Ratain MJ, Grochowski E, et al. Perceptions of cancer patients and their physicians involved in Phase I trials. J Clin Oncol. 1995;13:1062-1072.
8. Kahneman D, Tversky A. Variants of uncertainty. Cognition. 1982;11:143-157.
9. Hacking I. The emergence of probability: a philosophical study of early ideas about probability, induction, and statistical inference. New York: Cambridge University Press, 1975.
10. Hacking I. An introduction to probability and inductive logic. Cambridge: Cambridge University Press, 2001.
11. Degner LF, Kristjanson LJ, Bowman D, et al. Information needs and decisional preferences in women with breast cancer. JAMA. 1997;277:1485-1492.
12. The EuroQol Group. EuroQol - a new facility for the measurement of health-related quality of life. Health Policy. 1990;16:199-208.
13. Ganz PA, Lee JJ, Siau J. Quality of life assessment: an independent prognostic variable for survival in lung cancer. Cancer. 1991;67:3131-3135.
14. Gaskin DJ, Kong J, Meropol NJ, Yabroff KR, Weaver C, Schulman KA. Treatment choices by seriously ill patients: the Health Stock Risk Adjustment model. Med Decis Making. 1998;18:84-94.
15. O'Connor AM. Validation of a decisional conflict scale. Med Decis Making. 1995;15:25-30.
16. Stiggelbout AM, Kiebert GM, Kievit J, Leer JW, Stoter G, de Haes JC. Utility assessment in cancer patients: adjustment of time tradeoff scores for the utility of life years and comparison with standard gamble scores. Med Decis Making. 1994;14:82-90.
17. Verhoef LC, de Haan AF, van Daal WA. Risk attitude in gambles with years of life: empirical support for prospect theory. Med Decis Making. 1994;14:194-200.
18. Von Neuman J, Morgenstern O. Theory of games and economic behavior, 2nd edition. Princeton: Princeton University Press, 1947.
19. Ware J Jr., Kosinski M, Keller SD. SF-12: how to score the SF-12 Physical and Mental Health Summary Scales. Boston: The Health Institute, New England Medical Center, 1995.
20. Ware J Jr., Kosinski M, Keller SD. A 12-item shortform health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220-233.
21. Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 health survey: manual and interpretation guide. Boston: The Health Institute, New England Medical Center, 1993.
22. Grossman M. On the concept of health capital and the demand for health. J Pol Econ. 1972;80:168-199.
23. Schafer JL. Analysis of incomplete multivariate data. Boca Raton: Chapman & Hall/CRC, 1997.
24. Savitz DA, Olshan AF. Multiple comparisons and related issues in the interpretation of epidemiologic data. Am J Epidemiol. 1995;142:904-908.
25. Ghiselli EE, Campbell JP, Zedeck S. Measurement theory for the behavioral sciences. San Francisco: WH Freeman and Company, 1981.