Overexpression of dominant negative retinoic acid receptor α causes alveolar abnormality in transgenic neonatal lungs

Endocrinology

Volumn 144, Issue 7, 2003, Pages 3004-3011

  Yang, Li ^a   Naltner, Angela ^a   Yan, Cong ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; RETINOIC ACID RECEPTOR ALPHA; SECRETORY PROTEIN; SURFACTANT PROTEIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CLARA CELL; CONTROLLED STUDY; DOWNSTREAM PROCESSING; GENE; LUNG ALVEOLUS; LUNG DEVELOPMENT; LUNG PARENCHYMA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; RAT; RESPIRATORY EPITHELIUM; SURFACTANT PROTEIN B GENE; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; ANTIMALARIALS; DOXYCYCLINE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MICE, TRANSGENIC; PREGNANCY; PROMOTER REGIONS (GENETICS); PROTEINS; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; RATS; RECEPTORS, RETINOIC ACID; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; UTEROGLOBIN;

EID: 0038336760     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-0121     Document Type: Article

References (22)

1. Shenai JP, Stahlman MT, Chytil F 1981 Vitamin A delivery from parenteral alimentation solution. J Pediatr 99:661-663
2. Shenai JP, Chytil F, Stahlman MT 1985 Vitamin A status of neonates with bronchopulmonary dysplasia. Pediatr Res 19:185-188
3. Shenai JP, Kennedy KA, Chytil F, Stahlman MT 1987 Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia. J Pediatr 111:269-277
4. Massaro GD, Massaro D 1996 Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 270:L305-L310
5. Massaro GD, Massaro D 1997 Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. [Erratum (1997) 3:805] Nat Med 3:675-677
6. George TN, Snyder JM 1997 Regulation of surfactant protein gene expression by retinoic acid metabolites. Pediatr Res 41:692-701
7. Yan C, Ghaffari M, Whitsett JA, Zeng X, Sever Z, Lin S 1998 Retinoic acid-receptor activation of SP-B gene transcription in respiratory epithelial cells. Am J Physiol 275:L239-L246
8. Naltner A, Ghaffari M, Whitsett JA, Yan C 2000 Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent. J Biol Chem 275:56-62
9. Whitsett JA, Nogee LM, Weaver TE, Horowitz AD 1995 Human surfactant protein B: structure, function, regulation, and genetic disease. Physiol Rev 75:749-757
10. Clark JC, Wert SE, Bachurski CJ, Stahlman MT, Stripp BR, Weaver TE, Whitsett JA 1995 Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA 92:7794-7798
11. Nogee LM, Garnier G, Dietz HC, Singer L, Murphy AM, deMello DE, Colten HR 1994 A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds. J Clin Invest 93:1860-1863
12. Naltner A, Wert S, Whitsett JA, Yan C 2000 Temporal/spatial expression of nuclear receptor coactivators in the mouse lung. Am J Physiol Lung Cell Mol Physiol 279:L1066-L1074
13. Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M 1994 Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120:2749-2771
14. Ghaffari M, Whitsett JA, Yan C 1999 Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor. Am J Physiol 276:L398-L404
15. Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE 2002 Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol 283:L256-L264
16. Clark JC, Tichelaar JW, Wert SE, Itoh N, Perl AK, Stahlman MT, Whitsett JA 2001 FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am J Physiol Lung Cell Mol Physiol 280:L705-L715
17. Tichelaar JW, Lu W, Whitsett JA 2000 Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275:11858-11864
18. Yan C, Naltner A, Conkright J, Ghaffari M 2001 Protein-protein interaction of retinoic acid receptor α and thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem 276:21686-21691
19. Massaro D, Teich N, Maxwell S, Massaro GD, Whitney P 1985 Postnatal development of alveoli. Regulation and evidence for a critical period in rats. J Clin Invest 76:1297-1305
20. Bogue CW, Jacobs HC, Dynia DW, Wilson CM, Gross I 1996 Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture. Am J Physiol 271:L862-L868
21. Yan C, Sever Z, Whitsett JA 1995 Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1. J Biol Chem 270:24852-24857
22. Yang L, Naltner A, Kreiner A, Yan O, Cowen A, Du H, Yan C 2003 An enhancer region determines hSP-B gene expression in bronchiolar and alveolar type II epithelial cells in transgenic mice. Am J Physiol Lung Cell Mol Physiol 284:L481-L488