Estimation of daily oral exposure to phthalates derived from soft polyvinyl chloride baby toys

Journal of the Food Hygienic Society of Japan

Volumn 44, Issue 2, 2003, Pages

  Sugita, Takiko ^a   Kawamura, Yoko ^a   Tanimura, Masako ^b   Matsuda, Rieko ^a   Niino, Tatsuhiro ^c   Ishibashi, Toru ^c   Hirabahashi, Naoyuki ^d   Matsuki, Yasuhiko ^d   Yamada, Takashi ^a   Maitani, Tamio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b National Maritime Research Institute   (Japan)

^c Tokyo Kenbikyo in Foundation   (Japan)

^d HATANO RESEARCH INSTITUTE   (Japan)

Author keywords

Diisononyl phthalate (DINP); Exposure; Mouthing mouthing time; Oral release study; Phthalate; Polyvinyl chloride; Release amount; Toy

Indexed keywords

PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIISONONYL ESTER; POLYVINYLCHLORIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHILD BEHAVIOR; ENVIRONMENTAL EXPOSURE; EQUIPMENT; HUMAN; INFANT; MONTE CARLO METHOD; MOUTH; SALIVA LEVEL;

EID: 0038334820     PISSN: 00156426     EISSN: None     Source Type: Journal    
DOI: 10.3358/shokueishi.44.96     Document Type: Article

References (26)

1. Koizumi, M., Ema, M., Hirose, A., Hasegawa, R., Recent studies on toxic effects of phthalate esters on reproduction and development: Focus on di(2-ethylhexyl)phthalate and di-n-butyl phthalate. Nihon Shokuhin Kagaku Gakkaishi (Jpn. J. Food Chem.), 7, 65-73 (2000).
2. Koizumi, M., Ema, M., Hirose, A., Kurokawa, Y., Hasegawa, R., No observed adverse effect levels of phthalate esters on reproductive and developmental toxicity, the differences with age and species in testicular toxicity, and tolerable daily intake of DEHP. Nihon Shokuhin Kagaku Gakkaishi (Jpn. J. Food Chem.), 8, 1-10 (2001).
3. Wilkinson, F. C., Lamb, IV, C. J., The potential health effects of phthalate esters in children's toys: A review and risk assessment. Regulatory Toxicology and Pharmacology, 30, 140-155 (1999).
4. Poon, R., Lecavalier, P., Mueller, R., Valli, V. E., Procter, B. G., Chu, I., Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl)phthalate in the rat. Food and Chemical Toxicology, 35, 225-239 (1997).
5. Lamb IV, C. J., Chapin, R. E., Teague, J., Lawton, A. D., Reel, J. R., Reproductive effects of fore phthalic acid esters in the mouse. Toxicol. Appl. Pharmacol., 88, 255-269 (1987).
6. Arcadi, F. A., Costa, C., Imperatore, C., Marchese, A., Rapisarda, A., Salemi, M., Trimarchi, G. R., Costa, G., Oral toxicity of bis(2-ethylhexyl)phthalate during pregnancy and suckling in the long-evans rat. Food and Chemical Toxicology, 36, 963-970 (1998).
7. Waterman, J. S., Ambroso, L. J., Keller, H. L., Trimmer, W. G., Nikiforov, I. A., Harris, B. S., Developmental toxicity of di-isodecyl and di-isononyl phthalates in rats. Reproductive Toxicology, 13, 131-136 (1999).
8. Waterman, J. S., Keller, H. L., Trimmer, W. G., Freeman, J. J., Nikiforov, I. A., Harris, B. S., Nicolich, J. M., Mckee, H. R., Two-generation reproduction study in rats given di-isononyl phthalate in the diet. Reproductive Toxicology, 14, 21-36 (2000).
9. Lington, W. A., Bird, G. M., Plutnick, T. R., Stubblefield, A. W., Scala, A. R., Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats. Fundamental and Applied Toxicology, 36, 79-89 (1997).
10. Caldwell, J. D., Eldridge, R. S., Lington, W. A., Mckee, H. R., Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate. Toxicological Sciences, 51, 153-160 (1999).
11. Zacharewski, R. T., Meek, D. M., Clemons, H. J., Wu, F. Z., Fielden, R. M., Matthews, B. J., Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicological Sciences, 46, 282-293 (1998).
12. Harris, A. C., Henttu, P., Parker, G. M., Sumpter, P. J., The estrogenic activity of phthalate esters in vitro. Environmental Health Perspectives, 105, 802-811 (1997).
13. Sugita, T., Hirayama, K., Niino, T., Ishibashi, T., Yamada, T., Contents of phthalate in polyvinyl chloride toys. Shokuhin Eiseigaku Zasshi (J. Food Hyg. Soc. Japan), 42, 48-55 (2001).
14. Kawamura, Y., Tagai, C., Maehara, T., Yamada, T., Additives in polyvinyl chloride and polyvinylidene chloride products. Shokuhin Eiseigaku Zasshi (J. Food Hyg. Soc. Japan), 40, 274-284 (1999).
15. Könemann, W. H., ed., Phthalate release from soft PVC baby toys, Report from the Dutch consensus group. RIVM report 613320 002, RIVM Bilthoven, The Netherlands, September 1998.
16. Bartlett, S., Chu, I., Given, J., Lalonde, J. P., Moir, D., Parfett, C., Risk assessment on diisononyl phthalate in vinyl children's products. Investigation Report. Health Canada, Ottawa, Ontario, November 1998.
17. Babich, A. M., The risk of chronic toxicity associated with exposure to diisononyl phthalate (DINP) in children's products. U. S. Consumer Product Safety Commission (CPSC), Bethesda, MD, December 1998.
18. Official Journal of the European Communities, Commission Decision of 7 December 1999, Decision 1999/ 815/EC.
19. Official Journal of the European Communities, Commission Decision of 19 August 2002, Decision 2002/660/ EC.
20. th CSTEE plenary meeting, Brussels, 26/27 November 1998.
21. Groot, E. M., Lekkerkerk, C. M., Steenbekkers, P. A. L., Mouthing behaviour of young children; An observational study (summary report). RIVM report 613320 002, RIVM Bilthoven, The Netherlands, September 1998.
22. Niino, T., Ishibashi, T., Itoh, T., Sakai, S., Ishiwata, H., Yamada, T., Onodera, S., Comparison of diisononyl phthalate migration from polyvinyl chloride products into human saliva in vivo and into saliva simulant in vitro. Journal of Health Science, 48, 277-281 (2002).
23. Chen, S., Migration of DINP from polyvinyl chloride (PVC) children's products. U. S. Consumer Product Safety Commission (CPSC), Bethesda, MD, December 1998.
24. National Toxicology Program U.S. Department of Health and Human Services, Center for the evaluation of risks to human reprodution, NTP-CERHR expert panel report on diisononyl phthalate, October 2000.