Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: Involvement of benzodiazepine receptors

Epilepsia

Volumn 44, Issue 5, 2003, Pages 629-635

  Ahmadiani, Abolhassan ^a   Mandgary, Ali ^b   Sayyah, Mohammad ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Anticonvulsant; Bicuculline; BZD receptors; Flutamide; PTZ; Seizure

Indexed keywords

AMINOPHYLLINE; ANDROGEN RECEPTOR; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; BICUCULLINE; DIAZEPAM; ETHOSUXIMIDE; FLUTAMIDE; KAINIC ACID; PENTETRAZOLE; STRYCHNINE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; TREATMENT OUTCOME;

AMYGDALA; ANIMALS; ANTICONVULSANTS; CONVULSANTS; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROSHOCK; FLUTAMIDE; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAPERITONEAL; KINDLING, NEUROLOGIC; MALE; MICE; MICE, INBRED STRAINS; MOTOR SKILLS; MUSCULOSKELETAL EQUILIBRIUM; PENTYLENETETRAZOLE; PREMEDICATION; RATS; RECEPTORS, GABA-A; SEIZURES;

EID: 0038327536     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.36402.x     Document Type: Article

References (42)

1. Carmina E. Anti-androgens for the treatment of hirsutism. Expert Opin Invest Drugs 2002;11:357-63.
2. Klovenbag GJ, Iversen P, Newling DW. Antiandrogen monotherapy: a new form of treatment for patients with prostate cancer. Urology 2001;58:16-23.
3. Nayebi AR, Ahmadiani A. Involvement of the spinal serotonergic system in analgesia produced by castration. Pharmacol Biochem Behav 1999;64:467-71.
4. Naghdi N, Nafisy N, Majlessi N. The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water maze. Brain Res 2001;897:44-51.
5. Edwards HE, Burnham WM, MacLusky NJ. Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures. Brain Res 1999;838:151-7.
6. 3] Ro 5-4864 in rat prostate and seminal vesicle. Gen Pharmacol 1992;23:381-4.
7. Fryer RI. Ligand interaction at the benzodiazepine receptor. In: Hansch C, Sammes PG, Taylor J, eds. Comprehensive medicinal chemistry. Headington Hill Hall, Oxford: Pergamon Press, 1990:539-66.
8. Swinyard EA. Laboratory evaluation of antiepileptic drugs: review of laboratory methods. Epilepsia 1969;10:107-19.
9. Kim HJ, Moon KD, Oh SY, et al. Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci Lett 2001;314:65-8.
10. Gonzalez-Trujano ME, Navarrete A, Reyes B, et al. Anticonvulsant properties and bio-guided isolation of palmitone from leaves of Annona diversifolia. Planta Med 2001;67:136-41.
11. Loscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 1988;2:145-81.
12. Turski L, Stephens N, Jensen LH, et al. Anticonvulsant action of the β-carboline abecarnil: studies in rodents and baboon, Papio papio. J Pharmacol Exp Ther 1990;253:344-52.
13. A receptor. J Pharmacol Exp Ther 1997;280:1284-95.
14. Litchfield ST, Wilcoxon FA. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949;96:99-105.
15. Sayyah M, Valizadeh J, Kamalinejad M. Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazoleand maximal electroshock-induced seizures. Phytomedicine 2002;9:212-6.
16. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic Press, 1986.
17. Sayyah M, Ahmadiani A, Pourgholami MH. Evaluation of the anticonvulsant profile of progesterone in male amygdala-kindled rats. Epilepsy Res 1998;30:195-202.
18. Racine RJ. Modification of seizure activity by electrical stimulation, II: motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281-94.
19. Dunham NW, Miya TS. A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc 1957;46:208-9.
20. Engel JJR, Williamson PD, Wieser HG. Mesial temporal lobe epilepsy. In: Engel JJR, Pedley TA, eds. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott-Raven, 1997:2417-26.
21. Nadler JV. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 1981;29:2031-42.
22. Lothman EW, Collins RC. Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates. Brain Res 1981;218:299-318.
23. McNamara JO, Constant Byrne M, Dasheiff RM, et al. The kindling model of epilepsy: a review. Prog Neurobiol 1980;15:139-59.
24. Loscher W, Jackel R, Czuczwar SJ. Is amygdala kindling in rats a model for drug-resistant partial epilepsy? Exp Neurol 1986;93:211-26.
25. Macdonald RL, Barker JL. Pentylenetetrazole and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurons. Nature 1977;267:720-2.
26. 3H]-diazepam binding: in vitro: correlation with convulsant potency. Eur J Pharmacol 1982;78:353-6.
27. Coulter DA, Hugenard JR, Prince DA. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol 1989;25:582-93.
28. Macdonald RL, Kelly KM. Antiepileptic drug mechanism of action. Epilepsia 1995;36(suppl 2):2-12.
29. Rogawski MA, Porter RJ. Antiepileptic drugs and pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 1990;42:223-86.
30. White HS. New mechanisms of antiepileptic drugs. In: Porter R, Chadwick D, eds. Epilepsies II. Boston: Butterworth Heinemann, 1997:1-30.
31. Langer SZ, Arbilla S. Imidazopyridines as a tool for the characterization of benzodiazepine receptors: a proposal for a pharmacological classification as omega receptor subtypes. Pharmacol Biochem Behav 1988;29:763-6.
32. Shrivastava VK, Sathyanesan AG. Effect of antiandrogens on the hypothalamic gamma-aminobutyric acid (GABA) and glutamate contents of the Indian palm squirrel (Funambulus pennanti, Wroughton). Exp Clin Endocrinol 1986;87:349-52.
33. Joels M. Steroid hormones and excitability in the mammalian brain. Front Neuroendocrinol 1997;18:2-48.
34. Beyenburg S, Stoffel-Wagner B, Bauer J, et al. Neuroactive steroids and seizure susceptibility. Epilepsy Res 2001;44:141-53.
35. Randawski E, Perentesis G, Symchowicz S, et al. Single and multiple dose pharmacokinetic evaluation of flutamide in normal geriatric volunteers. J Clin Pharmacol 1988;29:554-8.
36. Schwartz-Giblin S, Korotzer A, Pfaf DW. Steroid hormone effects on picrotoxin-induced seizures in female and male rats. Brain Res 1989;476:240-7.
37. Thomas J, McLean JH. Castration alters susceptibility of male rats to specific seizures. Physiol Behav 1991;49:1177-9.
38. Frye CA, Reed TA. Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy. Psychoneuroendocrinology 1998;23:385-99.
39. Belelli D, Bolger MB, Gee KW. Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur J Pharmacol 1989;166:325-9.
40. Belelli D, Lan NC, Gee KW. Anticonvulsant steroids and GABA/benzodiazepine receptor-chloride ionophore complex. Neurosci Biobehav Rev 1990;14:315-22.
41. Kokate TG, Svensson BE, Rogawski MA. Anticonvulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation. J Pharmacol Exp Ther 1994;270:1223-9.
42. Swinyard EA, Sofia RD, Kupferberg HJ. Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. Epilepsia 1986;27:27-34.