A computational model of direct interstitial infusion of macromolecules into the spinal cord

Annals of Biomedical Engineering

Volumn 31, Issue 4, 2003, Pages 448-461

  Sarntinoranont, Malisa ^a,c   Banerjee, Rupak K ^b   Lonser, Russell R ^a   Morrison, Paul F ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b University of Cincinnati   (United States)

^c Drug Delivery and Kinetics Resource   (United States)

Author keywords

Albumin; Convection; Diffusion; FEM; Hydraulic conductivity; Mathematical model; Microinfusion; Permeability; Porous

Indexed keywords

CONTROLLED DRUG DELIVERY; DIFFUSION; FINITE ELEMENT METHOD; HYDRAULIC CONDUCTIVITY; MACROMOLECULES; MATHEMATICAL MODELS; MUSCULOSKELETAL SYSTEM; POROSITY; PROTEINS; TISSUE;

ALBUMIN; DORSAL COLUMN; INTERSTITIAL INFUSION; SPINAL CORD; THREE DIMENSIONAL FINITE ELEMENT MODEL;

BIOMEDICAL ENGINEERING;

ALBUMINOID;

ANIMAL; ANISOTROPY; ARTICLE; BIOLOGICAL MODEL; CHEMICAL MODEL; COMPUTER SIMULATION; DIFFUSION; EVALUATION; EXTRACELLULAR SPACE; FINITE ELEMENT ANALYSIS; FLOW KINETICS; INFUSION; INFUSION PUMP; KINETICS; MACROMOLECULE; METABOLISM; METHODOLOGY; MOTION; PARTICLE SIZE; PHYSIOLOGY; POROSITY; RAT; SPINAL CORD; THERMODYNAMICS; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL; VALIDATION STUDY; VERTEBRA;

ALBUMINS; ANIMALS; ANISOTROPY; BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; CONVECTION; DIFFUSION; EXTRACELLULAR SPACE; FINITE ELEMENT ANALYSIS; INFUSION PUMPS, IMPLANTABLE; INFUSIONS, PARENTERAL; KINETICS; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOTION; PARTICLE SIZE; POROSITY; RATS; RHEOLOGY; SPINAL CORD; THORACIC VERTEBRAE; TISSUE DISTRIBUTION;

EID: 0038323994     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/1.1558032     Document Type: Article

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