TCPL delivery devices: Endometrial changes associated with exogenous sustained release of ovarian hormones

Biomedical Sciences Instrumentation

Volumn 35, Issue , 1999, Pages 205-210

  Cason, Zelma ^a   Tucci, Michelle ^a   England, Barry ^a   Benghuzzi, Hamed ^a  

^a NONE

Author keywords

Ceramic drug delivery; DepoProvera; Endometrium; Ovarian events; Progestins; Vaginal smears

Indexed keywords

CERAMIC MATERIALS; GYNECOLOGY; HORMONES; IMPLANTS (SURGICAL); PHOSPHATE MINERALS;

HISTOPATHOLOGY; TRICALCIUM PHOSPHATE LYSINE;

CONTROLLED DRUG DELIVERY;

CALCIUM PHOSPHATE; CALCIUM PHOSPHATE CERAMIC; ESTROGEN; LYSINE DERIVATIVE; MEDROXYPROGESTERONE ACETATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL ULTRASTRUCTURE; CELL VACUOLE; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL; DRUG DELIVERY SYSTEM; ENDOMETRIUM; ESTRUS CYCLE; FEMALE; FEMALE GENITAL SYSTEM; HISTOPATHOLOGY; IMPLANTATION; NONHUMAN; OVARY; RAT; SUSTAINED RELEASE PREPARATION; UTERINE CERVIX; UTERINE TUBE; UTERUS; VAGINA; VAGINA SMEAR;

ANIMALS; CALCIUM PHOSPHATES; CERAMICS; DRUG COMBINATIONS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; ENDOMETRIUM; ESTRADIOL; FEMALE; GENITALIA, FEMALE; LYSINE; MEDROXYPROGESTERONE 17-ACETATE; ORGAN SIZE; PHOSPHATES; PROGESTERONE CONGENERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032929439     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (15)

1. Fotherby K, Koetsawang S, and Marthrubutham M (1980): Pharmacokinetic study of different doses of Depo Provera. Contraception.. 22(5)527-536.
2. Kirton KT and Cornette JC (1974): Return of ovulatory cyclicity following intramuscular injection of medroxyprogesterone acteate. Contraeption .10: 39-45.
3. Ortiz A, Hiroi M, Stanczyk FZ, Goebelsmann U and Mishell DR (1977). Serum MPA concentrations and ovarian function following intramuscular injection of Depo-Provera. J Clin Endocrinol. 44:32-38.
4. Rinehart W and Winter J (1975). Injectables and implants. Population Reports, Series K, No 1 K1-K16.
5. Center for Disease Control (1987). Combiantion oral contraceptive use and the risk of endometrial cancer. J.A.M.A. 257:796-800.
6. Gambrell RD (1985). Evidence supports estrogen-progesterone replacement therapy. Postgrad Med. 78:35-38.
7. Shapiro S, Kelly JP, Rosenberg L, Kaufman JL, Knapp RC, Stolley PD and Schottenfeld D (1985). Risk of localized and widespread endometrial cancer in relation to recent and discontiunued use of conjugated estrogens. N. Engl. J. Med 313:969-972.
8. Shaw, RW (1987). Adverse long-term administration of oral contraceptives: a review. Br. J. Obstet. Gynecol. 94:724-730.
9. Briggs M. (1976). Biochemical effects of oral contraceptives. Adv. Steroid Biochem Pharmacol. 5:60-66.
10. Swerdloff RS and Odell WD (1969). Serum luteinizing and follicle stimulating hormone levels during sequential and nonsequential contraceptive treatment of eugonadal women. J. Clin. Endocrinol. Metab. 29:157-163.
11. Benghuzzi, H.A., England, B.G. and Bajpai, P.K.: The Effects of Long-term Sustained Delivery of DHT by Polylactic Acid Impregnated and Noncoated Biodegradable Ceramic Devices in Male Rats. Journal of Bioactive and Compatible Polymers Vol. 6 pp. 115-128, 1991.
12. Benghuzzi, H.A., B.G. England, and P.K. Bajpai. Long Term Delivery of Testosterone By ALCAP Ceramics in Rats. Journal of Applied Biomaterials, Vol. 1, 233-240, 1990.
13. Benghuzzi, H.A., B.G. England, and P.K. Bajpai. The Delivery of Testosterone and Dihydrotestosterone by ALCAP Ceramic Implants in Rats. Journal of Investigative Surgery, Vol. 3, 197-215, 1990.
14. Wolkersdorfer GW and Bornstein SR (1998). Tissue remodeling in the adrenal gland. Biochem Pharmacol. 56(2): 163-171.
15. Bornstein SR, Ehrhart-Bornstein M, and Scherbaum WA (1997). Morphological and functional studies of the paracrine interaction between cortex and medulla in the adrenal gland. Microsc. Res Tech 36:520-533.