Microscopic structure of the large intestinal mucosa in piglets during an antibiotic-associated diarrhea

Journal of Veterinary Medical Science

Volumn 65, Issue 3, 2003, Pages 301-306

  Tsukahara, Takamitsu ^a,b   Iwasaki, Yoshie ^c   Nakayama, Keizo ^b,c   Ushida, Kazunari ^a  

^a KYOTO PREFECTURAL UNIVERSITY   (Japan)

^b Kyodoken Institute   (Japan)

^c Japan Cytology Research   (Japan)

Author keywords

Antibiotic associated diarrhea; Edema; Large intestinal mucosa; Piglet; Succinate

Indexed keywords

BACTERIA (MICROORGANISMS);

ANTIINFECTIVE AGENT; ENROFLOXACIN; POLYMYXIN B; QUINOLONE DERIVATIVE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; LARGE INTESTINE; MALE; MICROBIOLOGY; PATHOLOGY; SWINE; SWINE DISEASE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; DIARRHEA; FLUOROQUINOLONES; INTESTINE, LARGE; MALE; POLYMYXIN B; QUINOLONES; SWINE; SWINE DISEASES;

EID: 0038318844     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.65.301     Document Type: Article

References (29)

1. Ariake, K., Ohkusa, T., Sakurazawa, T., Kumagai, J., Eishi, Y., Hoshi, S. and Yajima, T. 2000. Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice. J. Med. Dent. Sci. 47: 233-241.
2. Aronsson, B., Mollby, R. and Nord, C. E. 1981. Occurrence of toxin -producing Clostridium difficile in antibiotic-associated diarrhea in Sweden. Med. Microbiol. Immunol. 170: 27-35.
3. Bugaut, M. 1987. Occurrence, absorption, and metabolism of short-chain fatty acids in the digestive tract of mammals. Comp. Biochem. Physiol. 86B: 439-472.
4. Engelhardt, W. V. 1995. Absorption of short-chain fatty acids from the large intestine, pp. 149-170. In: Physiological and Clinical Aspects of Short-Chain Fatty Acids (Cummings, J. H., Rombeau, J. L. and Sakata, T. eds.), Cambridge University Press, Cambridge.
5. Fekety, R. 2001. Antibiotic-associated diarrhea. pp. 293-317. In: Diarrheal Disease (Field, M. ed.), Elsevier Science, New York.
6. Fukui, S., Shimoyama, T., Tamura, K., Yamamura, M. and Satomi, M. 1997. Mucosal blood flow and generation of superoxide in rat experimental colitis induced by succinic acid. J. Gastroenterol. 32: 464-471.
7. George, W. L., Rofle, R. D. and Finegold, S. M. 1982. Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. J. Clin. Microbiol. 15: 1049-1053.
8. Högenauer, C., Hammer, H. F., Krejs, G. J. and Reisinger, E. C. 1998. Mechanisms and management of antibiotic-associated diarrhea. Clin. Infect. Dis. 27: 702-710.
9. Hori, S. and Shimoyama, T. 1991. Faecal bacterial flora and organic acids in patients with ulcerative colitis. J. Germfree Life Genotobiol. 21: 19-21 (in Japanese).
10. Hove, H. 1998. Lactate and short-chain fatty acid production in the human colon: implications for D-lactic acidosis, short-bowel syndrome, antibiotic-associated diarrhea, colonic cancer, and inflammatory bowel disease. Dan. Med. Bull. 45: 15-33.
11. Hove, H. and Mortensen, P. B. 1995. Influence of intestinal inflammation (IBD) and small and large bowel length on fecal short-chain fatty acids and lactate. Dig. Dis. Sci. 40: 1372-1380.
12. Ichikawa, H. and Sakata, T. 1997. Effect of L-lactic acid, short-chain fatty acids, and pH in cecal infusate on morphometric and cell kinetic parameters of rat cecum. Dig. Dis. Sci. 42: 1598-1610.
13. Kitajima, S., Takuma, S. and Morimoto, M. 1999. Tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine DSS-induced colitis. J. Vet. Med. Sci. 61: 67-70.
14. Mørtensen, P. B. and Clausen, M. R. 1995. Short-chain fatty acids, antibiotic-associated diarrhea, colonic adenomas, and cancer. pp. 373-389. In: Physiological and Clinical Aspects of Short-Chain Fatty Acids (Cummings, J. H., Rombeau, J. L. and Sakata, T. eds.), Cambridge University Press, Cambridge.
15. Rubinstein, R., Howard, A. V. and Wrong, O. M. 1969. In vivo dialysis of feces as a method of stool analysis. The organic anion component. Clin. Sci. 37: 549-564.
16. Sakata, T. 1997. Influence of short-chain fatty acids on intestinal growth and functions. pp. 191-199. In: Dietary Fiber in Health and Disease (Kritchevsky, D. and Bonfield, C. eds.), Plenum Press, New York.
17. Saunders, D. R. and Sillery, J. 1982. Effect of lactate and H+ on structure and function of rat intestine. Implications for the pathogenesis of fermentative diarrhea. Dig. Dis. Sci. 27: 33-41.
18. Shimazaki, T. 1992. Detection of cytotoxic substances from Bacteroides vulgatus isolated from ulcerative colitis. Nihon Daicyo-Koumonbyo Kaishi 45: 282-291 (in Japanese).
19. Stewart, C. S. and Bryant, M. P. 1988. The rumen bacteria. pp. 21-75. In: The Rumen Microbial Ecosystem (Hobson, P. N. ed.), Elsevier Applied Science, New York.
20. Tsukahara, T. and Ushida, K. 2000. Succinate accumulation in pig large intestine during the antibiotic-associated diarrhea (AAD) and isolation of succinate-producing bacteria. Reprod. Nutr. Dev. 40: 213.
21. Tsukahara, T. and Ushida, K. 2001. Organic acid profiles in feces of pigs with pathogenic or non-pathogenic diarrhea. J. Vet. Med. Sci. 63: 1351-1354.
22. Tsukahara, T. and Ushida, K. 2002. Succinate accumulation in pig large intestine during antibiotic-associated diarrhea and the constitution of succinate-producing flora. J. Gen. Appl. Microbiol. 48: 143-154.
23. Tsukahara, T., Azuma, Y. and Ushida, K. 2001. The effect of a mixture of live lactic acid bacteria on intestinal gas production in pigs. Microb. Ecol. Health Dis. 13: 105-110.
24. Tsukahara, T., Iwasaki, Y., Nakayama, K. and Ushida, K. 2002. An improved technique for the histological evaluation of the mucus-secreting status in rat cecum. J. Nutr. Sci. Vitaminol. 48: 311-314.
25. Umesaki, Y., Yajima, T., Yokokuwa, T. and Mutai, M. 1979. Effect of organic acid absorption or bicarbonate transport in rat colon. Pflügers Arch. 379: 43-47.
26. Ushida, K. and Sakata, T. 1998. Effect of pH on oligosaccharide fermentation by porcine cecal digesta. Anim. Sci. Technol. (Jpn.) 69: 100-107.
27. Vernia, P., Caprilli, R., Latella, G., Barbetti, F., Magliocca, F. M. and Cittadini, M. 1988. Fecal lactate and ulcerative colitis. Gastroenterology 95: 1564-1568.
28. Vernia, P., Gnaedinger, A., Hauck, W. and Breuer, R. I. 1988. Organic anions and the diarrhea of inflammatory bowel disease. Dig. Dis. Sci. 33: 1353-1358.
29. Zhang, J. and Lupton, J. 1994. Dietary fibers stimulate colonic cell proliferation by different mechanisms at different site. Nutr. Cancer 22: 267-276.