A biallelic gene polymorphism of CYP11B2 predicts increased aldosterone to renin ratio in selected hypertensive patients

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 6, 2003, Pages 2495-2500

  Nicod, Jérôme ^a   Bruhin, David ^a   Auer, Lucas ^a   Vogt, Bruno ^a   Frey, Felix J ^a   Ferrari, Paolo ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; RENIN; STEROIDOGENIC FACTOR 1;

ADULT; ALDOSTERONE RELEASE; ARTICLE; BINDING SITE; CARDIOVERSION; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; HAPLOTYPE; HOMOZYGOSITY; HORMONE SYNTHESIS; HUMAN; HYPERTENSION; INTRON; MAJOR CLINICAL STUDY; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MOLECULAR DYNAMICS; PATIENT SELECTION; PREDICTION; PREVALENCE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK; STATISTICAL MODEL; SUPINE POSITION;

EID: 0038305903     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021598     Document Type: Article

References (34)

1. Lim PO, Struthers AD, MacDonald TM 2002 The neurohormonal natural history of essential hypertension: towards primary or tertiary aldosteronism? J Hypertens 20:11-15
2. Brunner HR, Laragh JH, Baer L, Newton MA, Goodwin FT, Krakoff LR, Bard RH, Buhler FR 1972 Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med 286:441-449
3. Ferrari P, Bonny O 2003 Forms of mineralocorticoid hypertension. Vitam Horm 66:113-156
4. Luetscher JA, Weinberger MH, Dowdy AJ, Nokes GW, Balikian H, Brodie A, Willoughby S 1969 Effects of sodium loading, sodium depletion and posture on plasma aldosterone concentration and renin activity in hypertensive patients. J Clin Endocrinol Metab 29:1310-1318
5. Coghlan JP, Doyle AE, Jerums G, Scoggins BA 1972 The effects of sodium loading and deprivation on plasma renin and plasma and urinary aldosterone in hypertension. Clin Sci 42:15-23
6. Gordon RD 1995 Primary aldosteronism. J Endocrinol Invest 18:495-511
7. Lim PO, Dow E, Brennan G, Jung RT, MacDonald TM 2000 High prevalence of primary aldosteronism in the Tayside hypertension clinic population. J Hum Hypertens 14:311-315
8. Stowasser M 2001 Primary aldosteronism: revival of a syndrome. J Hypertens 19:363-366
9. Kaplan NM 2001 Cautions over the current epidemic of primary aldosteronism. Lancet 357:953-954
10. Lim PO, Jung RT, MacDonald TM 1999 Raised aldosterone to renin ratio predicts antihypertensive efficacy of spironolactone: a prospective cohort follow-up study. Br J Clin Pharmacol 48:756-760
11. Tobian L 1967 Renin release and its role in renal function and the control of salt balance and arterial pressure. Fed Proc 26:48-54
12. Miller RE, Vander AJ, Kowalczyk S, Geelhoed GW 1968 Aldosterone secretion and plasma renin during renin infusion and acute salt depletion. Am J Physiol 214:228-231
13. Takeda Y, Furukawa K, Inaba S, Miyamori I, Mabuchi H 1999 Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism. J Clin Endocrinol Metab 84:1633-1637
14. Davies E, Holloway CD, Ingram MC, Inglis GC, Friel EC, Morrison C, Anderson NH, Fraser R, Connell JM 1999 Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Hypertension 33:703-707
15. Paillard F, Chansel D, Brand E, Benetos A, Thomas F, Czekalski S, Ardaillou R, Soubrier F 1999 Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population. Hypertension 34:423-429
16. Bassett MH, Zhang Y, Clyne C, White PC, Rainey WE 2002 Differential regulation of aldosterone synthase and 11β-hydroxylase transcription by steroidogenic factor-1. J Mol Endocrinol 28:125-135
17. White PC, Slutsker L 1995 Haplotype analysis of CYP11B2. Endocr Res 21:437-442
18. Komiya I, Yamada T, Takara M, Asawa T, Shimabukuro M, Nishimori T, Takasu N 2000 Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension. Hypertension 35:699-703
19. Tamaki S, Iwai N, Tsujita Y, Kinoshita M 1999 Genetic polymorphism of CYP11B2 gene and hypertension in Japanese. Hypertension 33:266-270
20. Rossi E, Regolisti G, Perazzoli F, Negro A, Davoli S, Nicoli D, Sani C, Casali B 2001 -344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension. Am J Hypertens 14:934-941
21. Lim PO, Macdonald TM, Holloway C, Friel E, Anderson NH, Dow E, Jung RT, Davies E, Fraser R, Connell JM 2002 Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. J Clin Endocrinol Metab 87:4398-4402
22. Barbieri C, Ferrari C, Caldara R, Rampini P, Crossignani RM, Bergonzi M 1981 Effects of chronic prazosin treatment on the renin-angiotensin-aldosterone system in man. J Clin Pharmacol 21:418-423
23. Carpene G, Rocco S, Opocher G, Mantero F 1989 Acute and chronic effect of nifedipine in primary aldosteronism. Clin Exp Hypertens A 11:1263-1272
24. Trenkel S, Seifarth C, Schobel H, Hahn EG, Hensen J 2002 Ratio of serum aldosterone to plasma renin concentration in essential hypertension and primary aldosteronism. Exp Clin Endocrinol Diabetes 110:80-85
25. Lovati E, Richard A, Frey BM, Frey FJ, Ferrari P 2001 Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease. Kidney Int 60:46-54
26. Tuck ML, Dluhy RG, Williams GH 1975 Sequential responses of the renin-angiotensin-aldosterone axis to acute postural change: effect of dietary sodium. J Lab Clin Med 86:754-763
27. Weidmann P, Beretta-Piccoli C, Ziegler WH, Keusch G, Gluck Z, Reubi FC 1978 Age versus urinary sodium for judging renin, aldosterone, and catecholamine levels: studies in normal subjects and patients with essential hypertension. Kidney Int 14:619-628
28. Brand E, Chatelain N, Mulatero P, Fery I, Curnow K, Jeunemaitre X, Corvol P, Pascoe L, Soubrier F 1998 Structural analysis and evaluation of the aldosterone synthase gene in hypertension. Hypertension 32:198-204
29. Pojoga L, Gautier S, Blanc H, Guyene TT, Poirier O, Cambien F, Benetos A 1998 Genetic determination of plasma aldosterone levels in essential hypertension. Am J Hypertens 11:856-860
30. Schunkert H, Hengstenberg C, Holmer SR, Broeckel U, Luchner A, Muscholl MW, Kurzinger S, Dozing A, Hense HW, Riegger GA 1999 Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation 99:2255-2260
31. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG 2001 Replication validity of genetic association studies. Nat Genet 29:306-309
32. Clyne CD, Zhang Y, Slutsker L, Mathis JM, White PC, Rainey WE 1997 Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. Mol Endocrinol 11:638-649
33. Clark BJ, Combs R 1999 Angiotensin II and cyclic adenosine 3′, 5′-monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element. Endocrinology 140:4390-4398
34. Irony I, Kater CE, Biglieri EG, Shackleton CH 1990 Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma. Am J Hypertens 3:576-582