Effects of age on morphology, protein synthesis and secretagogue-evoked secretory responses in the rat lacrimal gland

Molecular and Cellular Biochemistry

Volumn 248, Issue 1-2, 2003, Pages 7-16

  Draper, Clare E ^a   Singh, Jaipaul ^a   Adeghate, Ernest ^b  

^a UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Acinar cells; Ageing; Immunohistochemistry; Lacrimal gland; Leucine; Protein synthesis; Rat

Indexed keywords

GROWTH HORMONE SECRETAGOGUE; HISTAMINE; LEUCINE; PEROXIDASE; SEROTONIN; SUBSTANCE P; TRITIUM; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACINAR CELL; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME RELEASE; EVOKED RESPONSE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LACRIMAL GLAND; MALE; MICROMORPHOLOGY; NONHUMAN; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; ROUGH ENDOPLASMIC RETICULUM;

AGE FACTORS; AGING; ANIMALS; CYTOPLASM; ENDOPLASMIC RETICULUM, ROUGH; GOLGI APPARATUS; HISTAMINE; IMMUNOHISTOCHEMISTRY; LACRIMAL APPARATUS; LEUCINE; MALE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; PEROXIDASES; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SUBSTANCE P; TIME FACTORS; VASOACTIVE INTESTINAL PEPTIDE;

ANIMALIA;

EID: 0038303645     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024159529257     Document Type: Article

References (32)

1. Stasior OG, Roen JL: Thoughts on the ductules of the ageing human lacrimal gland. Adv Exp Med Biol 350: 49-52, 1994
2. Bromberg BB, Welch MH: Lacrimal protein secretion: Comparison of young and aged rats. Exp Eye Res 40: 313-320, 1985
3. Draper CE, Adeghate EA, Lawrence PA, Pallot DJ, Garner A, Singh J: Age-related morphological changes and secretory responses in the lacrimal gland. J Aut Nerv Syst 69: 173-183, 1998
4. Kelly DE, Wood RL, Enders AC: Bailey's Textbook of Microscopic Anatomy, 18th edn. Williams and Wilkins, Baltimore, USA, 1984
5. Friedlaender MH: Ocular manifestations of Sjogrens-syndrome, Keratoconjunctivitis sicca. Rheum Dis Clin North Am 18: 591-608, 1992
6. Draper CE, Adeghate EA, Singh J, Pallot DJ: Evidence to suggest morphological alterations in lacrimal gland acini with ageing. Exp Eye Res 68: 265-276, 1999
7. Levenbook L: Protein synthesis in relation to insect ageing: An overview. In: K.G. Cellatz, R.S. Sohal (eds). Insect Ageing: Strategies and Mechanisms. Springer-Verlag, Heidelberg, 1986, pp 200-206
8. Webster GC: Effect of ageing on the components of the protein synthesis system. In: K.G. Collatz, R.S. Sohal (eds). Insect Ageing. Spinger-Verlag, Berlin, 1986, pp 207-216
9. Rattan SI: Protein synthesis and the components of protein synthetic machinery during cellular aging. Mutat Res 256: 115-25, 1991
10. Derventzi A, Rattan SI, Clark BFC: Phorbol ester PMA stimulates protein synthesis and increases the level of active elongation factors EF-1α and EF-2 in ageing human fibroblasts. Mech Ageing Dev 69: 193-205, 1993
11. Chen SL, Hartmann JF: Influence of age on the synthesis of macromolecules in the smooth muscle cells of the isolated myointimal mass in vitro. Artery 19: 177-183, 1992
12. Soltani-Mazouni N, Soltani N: Protein synthesis in the fat body of Tenebrio Moliter (L.) during oocyte maturation: Effect of diflubenzuron, cycloheimide and starvation. J Stored Prod Res 31: 117-122, 1995
13. Clavo AC, Wahl RL: Effects of hypoxia on the uptake of tritiated thymidine, L-leucine, L-methionine and FDG in cultured cancer cells. J Nucl Med 37: 502-506, 1996
14. Lee JD, Hwang O, Kim SW, Han S: Primary cultured chondrocytes of different origins respond differently to bFGF and TGF-β. Life Sci 61: 293-299, 1997
15. Mietz H, Chevez-Barrios P, Lieberman MW, Wendt M, Gross R, Basinger SF: Decorin and sumarin inhibit ocular fibroblast collagen production. Gaefe's Arch Clin Exp Ophthalmol 235: 399-403, 1997
16. Karnovsky MJ: A formaldehyde-glutaraldehyde fixative of light osmolarity for the use in electron microscopy. J Cell Biol 27: 137A, 1965
17. Reynolds ES: The use of lead citrate at high pH as an electron-opaque staining in electron microscopy. J Cell Biol 17: 208, 1963
18. 3H]-Leucine-labelled protein secretion in permeabilised rat pancreatic acini. Exp Physiol 75: 537-546, 1990
19. Herzog V, Sies H, Miller F: Exocytosis in secretory cells of rat lacrimal gland. J Cell Biol 70: 692-706, 1976
20. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951
22. Herzog V, Fahimi HD: A new and sensitive colorimetric assay of peroxidase using 3′,3′-diaminobenzidine as a hydrogen donor. Anal Biochem 5: 554-562, 1973
23. Herzog V, Miller F: The localisation of endogenous peroxidase in the lacrimal gland of the rat during post-natal development. J Cell Biol 53: 662-706, 1972
24. Bromberg BB, Cripps MM, Welch MH: Sympathomimetic protein secretion by young and aged lacrimal gland. Current Eye Res 5: 217-223, 1986
25. Jacobsson G, Peltohuikko M, Meister B: Decreased mRNA levels for exocytotic proteins in the pituitary of aged rats. Mech Ageing Dev 101: 33-41, 1998
26. Allain H, Bentue-Ferrer D: Central neurotransmission in the elderly. In: A, Macieira-Coelho (ed). Molecular Basis of Ageing. CRC Press, Boca Rattan, Florida, 1995, pp, 511-523
27. Seagrave J, Hildebrande R, Johnson LJ: Muscarinic signalling in submandibular salivary acinar cells of ageing rats. Arch Oral Biol 41: 425-430, 1996
28. Roth GS: Changes in tissue responsiveness to hormones and neurotransmitters during ageing. Exp Gerontol 30: 361-368, 1995
29. Rattan SI, Derventzi A: Altered cellular responsiveness during ageing. BioEssays 13: 601-606, 1991
30. Cristofalo VJ, Pignolo RJ, Rotenberg MO: Molecular changes with in vitro cellular senescence. Ann NY Acad Sci 663: 187-194, 1992
31. Williams RM, Singh J, Sharkey KA: Innervation and mast cells of the rat exorbital lacrimal gland: The effect of age. J Aut Nerv Syst 47: 95-110, 1994
32. Brack Ch, Shikama N, Ackermann R, Wichser U: The role of protein synthesis elongation factor EF-1α in ageing of Drosophila. In: E. Beregi, I.A. Gergely, K. Rajczi (eds). Recent Advances in Ageing Science. Monduzzi, Bologna, 1993, pp 67-73