Muscarinic signalling in submandibular salivary acinar cells of ageing rats

Archives of Oral Biology

Volumn 41, Issue 5, 1996, Pages 425-430

  Seagrave, Jeanclare ^a   Hildebrand, Rafael ^a   Johnson, Lizabeth J ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

acini; ageing; muscarinic; saliva

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CALCIUM; CALCIUM ION; DIAGNOSTIC AGENT; FLUORESCENT DYE; FURA 2; INOSITOL TRISPHOSPHATE; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PHOSPHOLIPASE C; QUINUCLIDINYL BENZILATE; TRITIUM;

ACINAR CELL; AGED; AGING; ANIMAL; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM CHANNEL; CELL CULTURE; CONTROLLED STUDY; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ION TRANSPORT; MALE; METABOLISM; NONHUMAN; RAT; RAT STRAIN; RECEPTOR BINDING; SALIVA; SALIVARY GLAND; SECRETION; SIGNAL TRANSDUCTION; SUBMANDIBULAR GLAND;

EID: 0030136082     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/0003-9969(96)00006-4     Document Type: Article

References (28)

1. Ahmad S. N., Alam S. Q. and Alam B. S. (1990) Effect of ageing on adenylate cyclase activity and G-proteins in rat submandibular salivary glands. Archs oral Biol. 35, 885-890.
2. Baum B. J. (1981) Evaluation of stimulated parotid saliva flow rate in different age groups. J. dent. Res. 60, 1292-1296.
3. Bodner L. and Baum B. J. (1984) Submandibular gland secretory function in young adult and aged rats. Comp. Biochem. Physiol. 77A, 235-238.
4. Bylund D. B., Martinez J. R., Camden J. and Jones S. B. (1982) Autonomic receptors in the developing submandibular glands of neonatal rats. Archs oral Biol. 27, 945-950.
5. Dehaye J. P. and Turner R. J. (1991) Isolation and characterization of rat submandibular intralobular ducts. Am. J. Physiol. 261, c490-c496.
6. Gandara B. K., Izutsu K. T., Truelove E. L., Ensign W. Y. and Sommers E. E. (1985) Age-related salivary flow rates in controls and patients with lichen planus. J. dent. Res. 64, 1149-1151.
7. 2+ indicators with greatly improved fluorescence properties. J. biol. Chem. 260, 3440-3450.
8. Gutman D. and Benaryeh H. (1974) The influence of age on salivary content and rate of flow. Int. J. oral Surg. 3, 314-317.
9. Heintze U., Birkhed D. and Bjorn H. (1983) Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex. Swed. dent. J. 7, 227-238.
10. Hosey M. M. (1983) Regulation of ligand binding to cardiac muscarinic receptors by ammonium ion and guanine nucleotides. Biochim. biophys. Acta 757, 119-127.
11. Kim S. K. and Allen E. D. (1994) Structural and functional changes in salivary glands during aging. Microsc. res. Technique. 28, 243-253.
12. Koller M. M., Maeda N., Purushotham K. R., Scarpace P. J. and Humphreys-Beher M. G. (1992) A biochemical analysis of parotid and submandibular salivary gland function with age after simultaneous stimulation with pilocarpine and isoproterenol in female NIA Fischer 344 rats. Archs oral Biol. 37, 219-230.
13. 2+ release mechanism in senescent rat parotid acinar cells. Biochim. biophys. Acta 1014, 73-77.
14. Martinez J. R. (1990) Cellular mechanisms underlying the production of primary secretory fluid in salivary glands. Crit. Rev. oral Biol. Med. 1, 67-78.
15. 36Cl fluxes in dispersed rat submandibular acini: effects of cetylcholine and transport inhibitors. Pflügers Archs. 403, 50-54.
16. 2+ mobilization in the rat submandibular gland during aging and subsequent chronic propranolol treatment. Mech. Ageing Dev. 61, 33-44.
17. 1-adrenergic receptor-G protein in rat parotid during aging. Am. J. Physiol. Cell Physiol. 262, C1181-1188.
18. Parvinen T. and Larmas M. (1982) Age dependency of stimulated salivary flow rate, pH and lactobacillus and yeast concentrations. J. dent. Res. 61, 1052-1055.
19. Percival R. S., Challacombe S. J. and Marsh P. D. (1994) Flow rates of resting whole and stimulated parotid saliva in relation to age and gender. J. dent. Res. 73, 1416-1420.
20. Quissell D. O. (1980) Secretory response of dispersed rat submandibular cells - I. Potassium release. Am. J. Physiol. 238, C90-C98.
21. Rajakumar G. and Scarpace P. J. (1994) Relationship between cAMP production and protein secretion in rat submandibular acini: evidence for loss of reserve capacity with age. Life Sci. 55, 761-766.
22. Sashima M. (1986) Age-related changes of rat submandibular gland: a morphometric and ultrastructural study. Oral Pathol. 15, 507-512.
23. 2 hydrolysis in parotid gland membranes from aged rats: defects in activation of G(alpha a/11). Archs Biochem. Biophys. 322, 219-326.
24. Scott J. (1977) Quantitative age changes in the histological structure of human submandibular glands. Archs oral Biol. 22, 221-227.
25. Scott J., Bodner L. and Baum B. J. (1986) Assessment of age-related changes in the submandibular and sublingual salivary glands of the rat using stereological analysis. Archs oral Biol. 31, 69-71.
26. Seagrave J. C., Barker S., Martinez A. M. and Martinez J. R. (1993). Muscarinic signaling pathway in submandibular cells of adult and early postnatal rats. Proc. Soc. exp. Biol. Med. 203, 490-500.
27. 2+ levels in rat submandibular granular ducts and acini. Am. J. Physiol. Gastrointest. Liver Physiol. 261, G359-G363.
28. Wu A. J., Baum B. J. and Ship J. A. (1995) Extended stimulated parotid and submandibular secretion in a healthy young and old population. J. Gerontol. Ser. A-Biol. Sci. Med. 50, M45-M48.