Assessment of the hypothalamo-pituitary-adrenal axis in patients treated with radiotherapy and chemotherapy for childhood brain tumor

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 7, 2003, Pages 3149-3154

  Schmiegelow, Marianne ^a   Feldt Rasmussen, U ^b   Rasmussen, A K ^b   Lange, M ^b   Poulsen, H S ^c   Muller J ^a  

^a Rigshospitalet   (Denmark)

^b Mental Health Services CPH   (Denmark)

^c FINSEN LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CISPLATIN; CORTICOTROPIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; HYDROCORTISONE; INSULIN; LOMUSTINE; METHOTREXATE; VINCRISTINE;

ADOLESCENT; ADRENAL INSUFFICIENCY; ADULT; AGE DISTRIBUTION; ARTICLE; BRAIN CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHILD; CONTROLLED STUDY; CORTICOTROPIN TEST; ENDOCRINE FUNCTION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS ADRENAL SYSTEM; INSULIN TOLERANCE TEST; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIATION DOSE;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFANT; LINEAR MODELS; MALE; PITUITARY-ADRENAL SYSTEM;

EID: 0038298288     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021994     Document Type: Article

References (43)

1. de Nully Brown P, Olsen JH, Hertz H, Carstensen B, Bautz A 1995 Trends in survival after childhood cancer in Denmark, 1943-87: a population-based study. Acta Paediatr 84:316-324
2. Bleyer WA 1999 Epidemiologic impact of children with brain tumors. Childs Nerv Syst 15:758-763
3. Shalet SM, Beardwell CG, Pearson D, Morris Jones PH 1976 The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol (Oxf) 5:287-290
4. Duffner PK, Cohen ME, Voorhess ML, MacGillivray MH, Brecher ML, Panahon A, Gilani BB 1985 Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study. Cancer 56:2189-2193
5. Brauner R, Rappaport R, Prevot C, Czernichow P, Zucker JM, Bataini P, Lemerle J, Sarrazin D, Guyda HJ 1989 A prospective study of the development of growth hormone deficiency in children given cranial irradiation, and its relation to statural growth. J Clin Endocrinol Metab 68:346-351
6. Livesey EA, Hindmarsh PC, Brook CG, Whitton AC, Bloom HJ, Tobias JS, Godlee JN, Britton J 1990 Endocrine disorders following treatment of childhood brain tumours. Br J Cancer 61:622-625
7. Schmiegelow M, Lassen S, Poulsen HS, Feldt-Rasmussen U, Schmiegelow K, Hertz H, Muller J 2000 Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. Clin Endocrinol (Oxf) 53:191-197
8. Sklar C, Constine LS 1995 Chronic neuroendocrinological sequelae of radiation therapy. Int J Radiat Oncol Biol Phys 31:1113-1121
9. Schmiegelow M, Lassen S, Weber L, Poulsen HS, Hertz H, Muller J 1999 Dosimetry and growth hormone deficiency following cranial irradiation of childhood brain tumors. Med Pediatr Oncol 33:564-571
10. Ahmed SR, Shalet SM, Campbell RH, Deakin DP 1983 Primary gonadal damage following treatment of brain tumors in childhood. J. Pediatr 103:562-565
11. Oberfield SE, Allen JC, Pollack J, New MI, Levine LS 1986 Long-term endocrine sequelae after treatment of medulloblastoma: prospective study of growth and thyroid function. J Pediatr 108:219-223
12. Constine LS, Woolf PD, Cann D, Mick G, McCormick K, Raubertas RF, Rubin P 1993 Hypothalamic-pituitary dysfunction after radiation for brain tumors [published erratum appears in N Engl J Med 1993 Apr 22; 328(16):1208] [see comments]. N Engl J Med 328:87-94
13. Livesey EA, Brook CG 1989 Thyroid dysfunction after radiotherapy and chemotherapy of brain tumours. Arch Dis Child 64:593-595
14. Schmiegelow M, Lassen S, Poulsen HS, Schmiegelow K, Hertz H, Andersson AM, Skakkebaek NE, Muller J 2001 Gonadal status in male survivors following childhood brain tumors. J Clin Endocrinol Metab 86:2446-2452
15. Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, Lange M, Poulsen HS, Müller J, A population-based study of thyroid function after radiotherapy and chemotherapy for a childhood brain tumor. J Clin Endocrinol Metab, in press
16. Oberfield SE, Nirenberg A, Allen JC, Cohen H, Donahue B, Prasad V, Schiff R, Pang S, Ghavimi F, David R, Chrousos G, Sklar C 1997 Hypothalamic-pituitary-adrenal function following cranial irradiation. Horm Res 47:9-16
17. Lange M, Svendsen OL, Skakkebaek NE, Muller J, Juul A, Schmiegelow M, Feldt-Rasmussen U 2002 An audit of the insulin-tolerance test in 255 patients with pituitary disease. Eur J Endocrinol 147:41-47
18. Jones SL, Trainer PJ, Perry L, Wass JA, Bessser GM, Grossman A 1994 An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year. Clin Endocrinol (Oxf) 41:123-128
19. Burke CW 1992 The pituitary megatest: outdated? Clin Endocrinol (Oxf) 36:133-134
20. Shah A, Stanhope R, Matthew D 1992 Hazards of pharmacological tests of growth hormone secretion in childhood. Br Med J 304:173-174
21. Fowler JF 1992 Modelling altered fractionation schedules. Br J Radiat 24(Suppl):187-192
22. Barendsen GW 1982 Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8:1981-1997
23. Kleihues P, Burger PC, Scheithauer BW 1993 The new WHO classification of brain tumours. Brain Pathol. 3:255-268
24. Bailey CC, Gnekow A, Wellek S, Jones M, Round C, Brown J, Phillps A, Neidhardt M 1995 Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II. Medical and Pediatric Oncology 25:166-178
25. Erturk E, Jaffe CA, Barkan AL 1998 Evaluation of the integrity of the hypothalamic-pituitary-adrenal axis by insulin hypoglycemia test. J Clin Endocrinol Metab 83:2350-2354
26. Abdu TA, Elhadd TA, Neary R, Clayton RN 1999 Comparison of the low dose short Synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. J Clin Endocrinol Metab 84:838-843
27. Siegel S, Castellan NJ 1988 Non-parametric statistics for the behavioral sciences. Singapore: McGraw-Hill
28. SPSS 1999 Statistical software for Windows release 100.5. Chicago: SPSS
29. Shankar RR, Jakacki RI, Haider A, Lee MW, Pescovitz OH 1997 Testing the hypothalamic-pituitary-adrenal axis in survivors of childhood brain and skull-based tumors. J Clin Endocrinol Metab 82:1995-1998
30. Ammari F, Issa BG, Millward E, Scanion MF 1996 A comparison between short ACTH and insulin stress tests for assessing hypothalamo-pituitary-adrenal function. Clin Endocrinol (Oxf) 44:473-476
31. Streeten DH, Anderson GHJ, Bonaventura MM 1996 The potential for serious consequences from misinterpreting normal responses to the rapid adrenocorticotropin test. J Clin Endocrinol Metab 81:285-290
32. Mayenknecht J, Diederich S, Bahr V, Plockinger U, Oelkers W 1998 Comparison of low and high dose corticotropin stimulation tests in patients with pituitary disease. J Clin Endocrinol Metab 83:1558-1562
33. Lindholm J, Kehlet H, Blichert-Toft M, Dinesen B, Riishede J 1978 Reliability of the 30-minute ACTH test in assessing hypothalamic-pituitary-adrenal function. J Clin Endocrinol Metab 47:272-274
34. Lindholm J, Kehlet H 1987 Re-evaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic-pituitary-adrenocortical function. Clin Endocrinol (Oxf) 26:53-59
35. Hurel SJ, Thompson CJ, Watson MJ, Harris MM, Baylis PH, Kendall-Taylor P 1996 The short Synacthen and insulin stress tests in the assessment of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol (Oxf) 44:141-146
36. Stewart PM, Corrie J, Seckl JR, Edwards CR, Padfield PL 1988 A rational approach for assessing the hypothalamo-pituitary-adrenal axis. Lancet 1:1208-1210
37. Clayton RN 1996 Short Synacthen test versus insulin stress test for assessment of the hypothalamo-pituitary-adrenal axis: controversy revisited. Clin Endocrinol (Oxf) 44:147-149
38. Bangar V, Clayton RN 1998 How reliable is the short synacthen test for the investigation of the hypothalamic-pituitary-adrenal axis? Eur J Endocrinol 139:580-583
39. Weintrob N, Sprecher E, Josefsberg Z, Weininger C, Aurbach-Klipper Y, Lazard D, Karp M, Pertzelan A 1998 Standard and low-dose short adrenocorticotropin test compared with insulin-induced hypoglycemia for assessment of the hypothalamic-pituitary-adrenal axis in children with idiopathic multiple pituitary hormone deficiencies. J Clin Endocrinol Metab 83:88-92
40. Crowne EC, Wallace WH, Gibson S, Moore CM, White A, Shalet SM 1993 Adrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation. Clin Endocrinol (Oxf) 39:297-305
41. Thaler LM, Blevins LSJ 1998 The low dose (1-microg) adrenocorticotropin stimulation test in the evaluation of patients with suspected central adrenal insufficiency. J Clin Endocrinol Metab 83:2726-2729
42. Tordjman K, Jaffe A, Trostanetsky Y, Greenman Y, Limor R, Stern N 2000 Low-dose (1 microgram) adrenocorticotrophin (ACTH) stimulation as a screening test for impaired hypothalamo-pituitary-adrenal axis function: sensitivity, specificity and accuracy in comparison with the high-dose (250 microgram) test. Clin Endocrinol (Oxf) 52:633-640
43. Dickstein G, Shechner C, Nicholson WE, Rosner I, Shen-Orr Z, Adawi F, Lahav M 1991 Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test. J Clin Endocrinol Metab 72:773-778